A Framework for Fitness-for-Purpose and Reuse in Computational Phenotyping
November 17, 2025
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Brand Name :
TEVA-Bromazepam MED Bromazepam APO-Bromazepam
Synonyms :
bromazepam
Class :
Benzodiazepine
Brand Name :
TEVA-Bromazepam MED Bromazepam APO-Bromazepam
Synonyms :
bromazepam
Class :
Benzodiazepine
Dosage forms and strengths Â
Oral tabletÂ
6 mgÂ
3 mgÂ
1.5 mgÂ
Dosage regimens are individualized, starting with lower initial doses and incrementally elevating them until they reach the ideal level
Regular dose outpatient
The suggested dose is 1.5 to 3 mg orally up to every 8 hours a day
Serious hospitalized
The suggested dose is 6 to 12 mg orally up to every 8-12 hours a day
The maximum suggested dose is 60 mg orally in a day
Duration of Treatment
The duration should be minimized, ideally within eight to twelve weeks encompassing a gradual reduction phase
Not indicatedÂ
Dosage forms and strengths Â
Oral tabletÂ
6 mgÂ
3 mgÂ
1.5 mgÂ
The maximum suggested dose is 3 mg orally every day to be taken in divided doses
Debilitated patients
The maximum suggested dose is 3 mg orally every day to be taken in divided doses
bromazepam: they may enhance the serum concentration of CYP1A2 Inhibitors
bromazepam: they may enhance the serum concentration of CYP1A2 Inhibitors
bromazepam: they may enhance the serum concentration of CYP1A2 Inhibitors
bromazepam: they may enhance the serum concentration of CYP1A2 Inhibitors
bromazepam: they may enhance the serum concentration of CYP1A2 Inhibitors
When bromazepam is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
bromazepam has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When captodiame is used together with bromazepam, There is a risk or seriousness of CNS depression is enhanced
When bromazepam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when bromazepam is used together with fencamfamin
Combining tegafur with bromazepam can reduce tegafur’s metabolism
When bromazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When bromazepam is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
tinidazole has the potential to reduce the rate of excretion of bromazepam, potentially leading to an elevation in level of serum
When chlordiazepoxide is used together with bromazepam, this leads to enhanced risk or seriousness of CNS depression
When bromazepam is used together with somatotropin, this leads to a rise in bromazepam’s metabolism
When bromazepam is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with bromazepam, this leads to enhanced risk or seriousness of CNS depression
When bromazepam is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with bromazepam, this leads to enhanced risk or seriousness of CNS depression
bromazepam leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bromazepam which leads to increased level of serum
bromazepam leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
bromazepam leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
bromazepam leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
bromazepam leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
bromazepam: it may decrease the excretion rate of iothalamic acid
bromazepam: it may decrease the therapeutic efficacy of oxtriphylline
bromazepam: it may increase the risk of CNS depression with pridinol
bromazepam: it may decrease the therapeutic efficacy with bamifylline
bromazepam may decrease the excretion rate of almasilate, leading to higher serum levels
CYP1A2 inhibitors increase the concentration of bromazepam in serum
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
when bromazepam and bortezomib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and capmatinib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and carmustine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and cinacalcet are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and cilostazol are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and cinnarizine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and cinoxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and ciprofloxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and clopidogrel are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and dasatinib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and dapagliflozin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and dacarbazine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and dexfenfluramine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and diacerein are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and diclofenac are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and dihydralazine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and disopyramide are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and domperidone are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and dosulepin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and enasidenib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and enoxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and entecavir are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and erlotinib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and estradiol are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and estrone sulfate are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and ethinylestradiol are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and etoposide are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and fexinidazole are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and flecainide are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and fluorouracil are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and flutamide are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and grepafloxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and imatinib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and imipramine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and isoniazid are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and leniolisib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and lidocaine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and lomefloxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and mefenamic acid are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and methimazole are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and methoxsalen are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and mexiletine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and moxifloxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and naproxen are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and nevirapine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and nifedipine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and norfloxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and pacritinib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and pefloxacin are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and praziquantel are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and propranolol are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and quinidine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and ranitidine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and rofecoxib are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and tacrine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and terbinafine are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and triclabendazole are used together, there is a potential reduction in the bromazepam's metabolism
when bromazepam and verapamil are used together, there is a potential reduction in the bromazepam's metabolism
bromazepam might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum:Â
Action:Â
Anxiolytic (Anti-Anxiety): bromazepam is primarily used to alleviate symptoms of anxiety disorders. GABA, a neurotransmitter, is enhanced in the brain by it. An inhibitory neurotransmitter called GABA helps to control excessive neural activity, which lowers stress and anxiety.Â
Sedative: bromazepam has sedative properties, which means it can induce relaxation and drowsiness. This makes it useful in the short-term treatment of insomnia and as a preoperative medication to reduce anxiety before surgery.Â
Frequency not defined Â
Cardiovascular: tachycardia, palpitations, hypotension, Cardiac failureÂ
Dermatologic: skin rash, PruritusÂ
Endocrine & metabolic:Â Â
Gastrointestinal: xerostomia, vomiting, nausea, Gastrointestinal distress Â
Nervous system: impaired consciousness, nervousness, confusion, fatigue, emotional disturbance, headacheÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: Individuals with a known hypersensitivity or allergy to bromazepam or benzodiazepines should not take this medicationÂ
Myasthenia Gravis: bromazepam should be used with caution or avoided in individuals with myasthenia gravis, a neuromuscular disorder, as it can worsen muscle weakness.Â
Severe Respiratory Insufficiency: People with severe respiratory insufficiency, including conditions like severe chronic obstructive pulmonary disease (COPD), should not use bromazepam due to the potential for respiratory depression.Â
Sleep Apnea: Individuals with sleep apnea should be cautious when using bromazepam, as it may exacerbate the condition and increase the risk of breathing difficulties during sleep.Â
Acute Narrow-Angle Glaucoma: bromazepam should not be used in individuals with acute narrow-angle glaucoma, as it can increase intraocular pressure.Â
Severe Liver Disease: People with severe liver impairment or liver failure should use bromazepam with caution, as the drug is metabolized in the liver, and impaired liver function can lead to increased drug levels in the bloodstream.Â
Pregnancy and Breastfeeding: It is typically discouraged to use bromazepam during pregnancy, particularly in the initial trimester., as it may increase the risk of congenital malformations. It can also be excreted into breast milk, so it should be used with caution while breastfeeding.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is knownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â Â
bromazepam is categorized within the benzodiazepine drug class. It is primarily prescribed for its anxiolytic (anxiety-reducing) and sedative properties.Â
Pharmacodynamics:Â Â
Anxiolytic (Anti-Anxiety) Effects: bromazepam works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity. By increasing GABA’s effects, bromazepam helps reduce anxiety and tension. It’s often prescribed for generalized anxiety disorder and other anxiety-related conditions.Â
Sedative-Hypnotic Effects: bromazepam can induce drowsiness and promote sleep when taken at higher doses. This sedative effect makes it useful for treating insomnia and sleep disturbancesÂ
Pharmacokinetics:Â
AbsorptionÂ
After oral administration, bromazepam is absorbed from the gastrointestinal tract into the bloodstream. Â
DistributionÂ
Once absorbed, bromazepam is distributed throughout the body. Â
MetabolismÂ
bromazepam is metabolized in the liver by various cytochrome P450 enzymes, including CYP3A4 and CYP2C19. These enzymes play a significant role in converting bromazepam into its active metabolites. The primary active metabolite of bromazepam is 3-hydroxybromazepam. These metabolites are further metabolized and eventually excreted from the body.Â
Excretion and EliminationÂ
The metabolites of bromazepam and any unchanged drug are excreted primarily through the urine. The half-life of bromazepam can vary between individuals but is generally 20 to 30 hours. It may take several days for the drug and its metabolites to be eliminated from the body.Â
Administration: Â
The route of administration is oralÂ
Patient information leafletÂ
Generic Name: bromazepamÂ
Why do we use bromazepam? Â
Anxiety Disorders: bromazepam is prescribed to treat various anxiety disorders. It helps alleviate the symptoms of excessive worry, nervousness, and fear associated with these conditions.Â
Insomnia: bromazepam can be used as a short-term solution for insomnia (sleeping difficulties) due to its sedative effects. However, it is generally not recommended for long-term use because of the risk of dependence.Â
Muscle Relaxation: bromazepam’s muscle relaxant properties make it useful in treating muscle spasms and tension associated with conditions like muscle injuries, back pain, or other musculoskeletal issues.Â
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