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Brand Name :
CaCl or CaCl(2)
Synonyms :
calcio cloruro, calcium (2+) chloride
Class :
Antidotes and other calcium salts
Brand Name :
CaCl or CaCl(2)
Synonyms :
calcio cloruro, calcium (2+) chloride
Class :
Antidotes and other calcium salts
Dosage Forms & StrengthsÂ
Injectable solutionÂ
100mg/mlÂ
Indicated for emergency treatment of hypocalcemia
500-1000 mg intravenously for 5-10 minutes
Repeat if required
The emerging arrhythmias associated with hyperkalemia hypocalcemia, or hypermagnesemia
500-1000 mg intravenously for 5-10 minutes
500-1000 mg intravenously for 2-5 minutes
Monitor the patient for any signs of recovery
Repeat the dose if CNS depression stays
Indicated for overdose of calcium Channel Blocker
1-2 gm infused intravenously for 10-20 minutes
Repeat every 20 minutes as required for upto 5 doses
Indicated for an overdose of Beta-blocker
1000 mg bolus intravenously through a central line
Dosage Forms & StrengthsÂ
Injectable solutionÂ
100mg/mlÂ
Indicated for the emergency treatment of hypocalcemia
For Infants: <75 mg of calcium chloride that includes 20 mg of elemental calcium intravenously
Repeat the dose as required
For children: 75-519 mg of calcium chloride that includes 20-140 mg elemental calcium intravenously
Repeat the dose as required
Refer to the adult dosingÂ
may diminish the absorption when combined with quinolones
may diminish the absorption when combined with quinolones
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium chloride: it may increase the risk or severity of QTc prolongation
calcium chloride: it may increase the risk or severity of QTc prolongation
calcium chloride: it may increase the risk or severity of QTc prolongation
calcium chloride: it may increase the risk or severity of QTc prolongation
calcium chloride: it may increase the risk or severity of QTc prolongation
may diminish the serum concentration when combined with vitamin D analogs
when both drugs are combined, there may be an increased risk or severity of adverse effects  
may increase the CNS depressant effect of CNS Depressants
ciprofloxacin inhaled (Pending FDA approval)Â
may diminish the absorption of Quinolones
bictegravir: they may diminish the serum concentration of calcium salts
antacids: they may diminish the serum concentration of calcium salts
antacids: they may diminish the serum concentration of calcium salts
antacids: they may diminish the serum concentration of calcium salts
antacids: they may diminish the serum concentration of calcium salts
antacids: they may diminish the serum concentration of calcium salts
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
When both drugs are combined, there may be a decrease in levels of the other by inhibition of GI absorption  
oral form of calcium chloride inhibits the GI absorption of doxycycline (provide 2 hours difference between both drugs)
calcium salts have the potential to intensify the adverse or toxic effects of calcium acetate
levonorgestrel: they may diminish the serum concentration of calcium salts
metronidazole/tetracycline/bismuth subsalicylateÂ
the levels of either of the drugs, i.e., calcium chloride or tetracycline, can be decreased due to the inhibition of gastrointestinal absorption
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
may enhance the adverse/toxic effect of vitamin D analogs
may decrease the therapeutic effect when combined with calcium channel blockers
may decrease the therapeutic effect when combined with calcium channel blockers
may decrease the therapeutic effect when combined with calcium channel blockers
may decrease the therapeutic effect when combined with calcium channel blockers
may decrease the therapeutic effect when combined with calcium channel blockers
bismuth subcitrate, metronidazole and tetracycline
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
It may enhance the levels when combined with sodium polystyrene sulfonate by diminishing renal clearance
It may diminish the effect when combined with manganese by inhibiting the gastrointestinal absorption
they decrease the efficacy of calcium channel blockers
they decrease the efficacy of calcium channel blockers
they decrease the efficacy of calcium channel blockers
they decrease the efficacy of calcium channel blockers
they decrease the efficacy of calcium channel blockers
calcium salts: they may decrease the therapeutic effect of laxatives
calcium salts: they may decrease the therapeutic effect of laxatives
calcium salts: they may decrease the therapeutic effect of laxatives
calcium salts: they may decrease the therapeutic effect of laxatives
sodium picosulfate, citric acid, and magnesium oxide
calcium salts: they may decrease the therapeutic effect of laxatives
calcium salts enhance the arrhythmogenic effects of cardiac glycosides
calcium salts enhance the arrhythmogenic effects of cardiac glycosides
calcium salts enhance the arrhythmogenic effects of cardiac glycosides
may diminish the calcium salts excretion
may diminish the calcium salts excretion
calcium chloride: it may decrease the therapeutic efficacy of oxprenolol
When calcium chloride is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
combining calcipotriol with calcium chloride may amplify the risk or intensity of adverse effects
the risk or magnitude of adverse effects can be heightened when tacalcitol is connected with calcium chloride
spironolactone and hydrochlorothiazide
may diminish the excretion of thiazide diuretics
may diminish the excretion of thiazide diuretics
may diminish the excretion of thiazide diuretics
may diminish the excretion of thiazide diuretics
may diminish the excretion of thiazide diuretics
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
calcium salts reduces the efficacy of dobutamine
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
may increase the hypotensive effect of anti-hypertensives
may increase the toxic effect of Vitamin D analogs
may decrease the therapeutic effect of calcium channel blockers
hydrochlorothiazide/aliskirenÂ
may decrease the excretion of thiazide, and thiazide like diuretics
may decrease the therapeutic effect of calcium channel blockers
may increase the toxic effect when combined
calcium salts have the potential to intensify the arrhythmogenic effect of cardiac glycosides
calcium salts have the potential to intensify the arrhythmogenic effect of cardiac glycosides
calcium salts have the potential to intensify the arrhythmogenic effect of cardiac glycosides
calcium salts can increase the adverse and potentially toxic effects of Vitamin D Analogs
The therapeutic efficacy of dobutamine may be diminished when used concurrently with calcium salts
folic acid decreases the absorption of calcium salts in the blood stream
antacids: they may diminish the absorption of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the therapeutic effect of calcium salts
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
Actions and Spectrum:Â
calcium chloride is a source of calcium, which is necessary for strong bones and teeth. It is a potent activator of the coagulation cascade and can be used to promote hemostasis (clotting) in cases of bleeding or hemorrhage.Â
calcium chloride has some antiarrhythmic effects and can treat certain abnormal heart rhythms. It helps to counteract the effects of excess potassium on the heart and other organs.Â
Frequency not definedÂ
HypophosphatemiaÂ
HypotensionÂ
ErythemaÂ
HypomagnesemiaÂ
Tissue necrosis on the injection siteÂ
VasodilationÂ
HypercalcemiaÂ
NauseaÂ
Serum amylase increasedÂ
Tingling sensationsÂ
WeaknessÂ
Renal calculiÂ
Hot flashesÂ
Black Box Warning:Â
NoneÂ
Contraindication/Caution:Â
Pregnancy consideration:Â Â
Category AÂ
Breastfeeding warnings:Â Â
The drug is safe during lactation.Â
Pregnancy category:Â
Pharmacology:Â
calcium chloride is an electrolyte that conducts electricity in the body and plays a role in maintaining the body’s fluid balance, pH, and nerve and muscle function.Â
calcium chloride has positive inotropic and chronotropic effects on the heart, increasing the strength and rate of the heartbeat. It can be used in treating certain arrhythmias and during cardiac resuscitation.Â
Pharmacodynamics:Â
calcium chloride promotes hemostasis (clotting) and is often used to treat bleeding or hemorrhage.Â
It can also treat hyperkalemia (high potassium levels) by reducing the excitability of cell membranes; they include those of the heart and skeletal muscles.Â
Pharmacokinetics:Â
AbsorptionÂ
calcium chloride is usually administered by intravenous (IV) injection, allowing rapid and complete absorption into the bloodstream.Â
DistributionÂ
calcium ions are distributed throughout the body and are primarily bound to proteins in the plasma and tissues. calcium ions can cross cell membranes and enter cells, playing a role in various physiological processes.Â
MetabolismÂ
calcium chloride does not undergo significant metabolism in the body and is primarily excreted in the urine.Â
Elimination and Excretion Â
calcium ions are excreted primarily by the kidneys, with a small amount excreted in the feces. The excretion rate can be affected by factors such as renal function and other drugs that may interfere with calcium ion transport or excretion.Â
Administration:Â
calcium chloride is usually administered by intravenous (IV) injection and should only be given by a healthcare professional trained in its use. The dose and rate of administration depend on the specific indication and the patient’s age, weight, and clinical status.Â
Patient information leafletÂ
Generic Name: calcium chlorideÂ
Pronounced: KAL-see-um-KLOR-ide Â
Why do we use calcium chloride?Â
calcium chloride is used primarily to treat hypocalcemia, hyperkalemia, calcium channel blocker, and cardiac resuscitation as an adjunct.
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