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Brand Name :
Norpramin
Synonyms :
desipramine
Class :
Antidepressants and antianxiety drugs; norepinephrine reuptake inhibitors
Brand Name :
Norpramin
Synonyms :
desipramine
Class :
Antidepressants and antianxiety drugs; norepinephrine reuptake inhibitors
Dosage forms & Strengths
Tablet
10 mg
25 mg
50 mg
75 mg
100 mg
150 mg
100 - 200
mg
Orally 
at bedtime or divided 2 times daily
may be increase up to 300 mg daily when severely ill
Dosage forms & Strengths
Tablet
10 mg
25 mg
50 mg
75 mg
100 mg
150 mg
Age > 12 years:
25 - 50
mg
Orally 
every day
increase up to 100 mg daily if required divided 2 times a day
maximum dose is 150 mg daily
refer adult dosing
It may enhance QTc interval when combined with pentamidine
it increases the effect of anticholinergic agents
it increases the toxicity of norepinephrine reuptake inhibitors
it increases the effect of serotonergic agents
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
anticholinergic agents decrease the efficacy of levosulpride
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
CNS depressants increase the CNS suppression effect of thalidomide
it increases the effect of Norepinephrine Reuptake Inhibitors
CNS depressants increase the CNS depressing effect of brexanolone
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
it increases the effect of CNS depressants
it increases the toxicity of serotonergic agents
it increases the effect of CNS depressants
anticholinergic agents increase the toxicity of topiramate
It may reduce the effects when combined with pleurisy root by an unspecified interactions mechanism
it may diminish the therapeutic efficacy when combined with castor oil
it may diminish the excretion rate when combined with gadofosveset, resulting in an enhanced serum level
desipramine together with cisapride lead to an elevation of the QTc interval
it may diminish the excretion rate when combined with pentastarch, resulting in an enhanced serum level
The potential for increased CNS depression risk or seriousness occurs when desipramine is used together with pinazepam
when ajmaline is used together with desipramine, the risk or seriousness of QTc prolongation is enhanced
The potential for increased CNS depression risk or seriousness occurs when desipramine is used together with pipecuronium
When desipramine is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
desipramine has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When desipramine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when desipramine is used together with fencamfamin
When desipramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When alprazolam and desipramine is used together, this leads to reduction in the alprazolam’s metabolism
tinidazole has the potential to reduce the rate of excretion of desipramine, potentially leading to an elevation in level of serum
When encainide is used together with desipramine, this leads to a reduction in the encainide’s metabolism
desipramine: they may enhance the serum concentration of CYP2D6 Inhibitors
desipramine: they may enhance the serum concentration of CYP2D6 Inhibitors
desipramine: they may enhance the serum concentration of CYP2D6 Inhibitors
desipramine: they may enhance the serum concentration of CYP2D6 Inhibitors
desipramine: they may enhance the serum concentration of CYP2D6 Inhibitors
When desipramine is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When ponesimod is used together with desipramine, this leads to enhanced risk or seriousness of bradycardia
When desipramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When desipramine is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When emylcamate is used together with desipramine, this leads to enhanced risk or seriousness of CNS depression
When bufexamac is used together with desipramine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When indisulam is used together with desipramine, this leads to a reduction in desipramine metabolism
When desipramine is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When desipramine is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
glycopyrrolate inhaled and formoterolÂ
may increase the QTc interval when combined
may diminish the antihypertensive activity when combined
may enhance the serum concentrations of CYP2D6 inhibitors
the risk of QTc prolongation may be increased
the rate of metabolism may be altered
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
anticholinergic agents increase the effect of constipation of clozapine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of norepinephrine reuptake inhibitors
anticholinergic agents decrease the efficacy of secretin
CNS depressants increase the effect of zolpidem
Actions and Spectrum:
The exact mechanism of action of desipramine is not fully understood, but it is believed to work by inhibiting the reuptake of norepinephrine, a neurotransmitter involved in regulating mood. By blocking the reuptake of norepinephrine, desipramine increases its availability in the brain, which can help alleviate symptoms of depression and improve mood.
Desipramine has a broad spectrum of effects, primarily related to its action on various neurotransmitter systems in the brain. Apart from inhibiting norepinephrine reuptake, desipramine also has some affinity for blocking the reuptake of other neurotransmitters such as serotonin and dopamine, although to a lesser extent.
Frequency undefined:Â
FatigueÂ
LethargyÂ
SedationÂ
WeaknessÂ
Dry mouthÂ
Blurred visionÂ
VomitingÂ
SweatingÂ
InsomniaÂ
HeadacheÂ
AnxietyÂ
AgitationÂ
TinnitusÂ
RashÂ
Sexual dysfunctionÂ
ConfusionÂ
Black Box Warning:
None
Desipramine is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.Â
Pregnancy consideration:Â Â
Desipramine should only be used in a pregnant woman if the potential benefits outweigh the risk to the fetus.Â
Breastfeeding warnings:Â Â
Use the drug cautiously during lactation, as desipramine is excreted in breast milk.Â
Pregnancy category:Â
Pharmacology:
Desipramine is a tricyclic antidepressant that is primarily used in the treatment of depression. It is also sometimes prescribed for other conditions, such as attention deficit hyperactivity disorder (ADHD) and neuropathic pain. When discussing the pharmacology and ADME (absorption, distribution, metabolism, and excretion) of desipramine, it’s important to note that individual variations can occur due to factors such as age, genetics, and other concurrent medications.
Pharmacodynamics:
desipramine is a tricyclic antidepressant drug that works by inhibiting the reuptake of norepinephrine in the brain. As a result, it increases the concentration of norepinephrine in the synaptic cleft, leading to improved mood and reduced symptoms of depression.
Pharmacokinetics:
Absorption
desipramine is well absorbed from the gastrointestinal tract after oral administration. However, the absorption rate can be variable among individuals.
Distribution
desipramine has a large volume of distribution, indicating that it distributes widely throughout the body. It readily crosses the blood-brain barrier, which contributes to its central nervous system effects.
Metabolism
desipramine is primarily metabolized in the liver by the cytochrome P450 enzyme system, particularly CYP2D6.
Elimination and Excretion
The elimination half-life of desipramine ranges from 12 to 48 hours, with an average of around 24 hours. It is primarily eliminated in the urine, mainly as metabolites.
Administration:
The dosage of desipramine can vary depending on the individual’s condition, response to the medication, and other factors. It is important to follow the prescribed dosage as instructed by your healthcare provider. Typically, the starting dose for adults is around 25-50 mg per day, which may be gradually increased over time.
desipramine is usually taken orally in the form of tablets or capsules. It is typically taken one to three times a day, depending on the prescribed dosage and individual needs. It is generally recommended to take the medication at the same time(s) each day to maintain consistent blood levels.
The duration of desipramine treatment can vary depending on the individual and the nature of their condition.
Patient information leafletÂ
Generic Name:Â desipramineÂ
Pronounced: deh-si-prah-mineÂ
Why do we use desipramine?Â
desipramine is primarily used in the treatment of depression. It belongs to a class of medications known as tricyclic antidepressants (TCAs).
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