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Brand Name :
Efnocar, Efonta, Efnipine
Synonyms :
efonidipine
Class :
Antianginal Agent, Antihypertensive, Calcium Channel Blocker
Dosage Forms & Strengths
Tablet
20 mg
40 mg
Take a dose of 20 to 40 mg orally daily in 1 to 2 divided doses
Daily dose should not be more than 60 mg
Not determined
Refer to adult dosing
they increase the efficacy of hypotension-associated agents
it reduces the efficacy of blood pressure-lowering agents
may enhance the hypotensive effect
may enhance the hypotensive effect
may enhance the hypotensive effect
may enhance the hypotensive effect
may enhance the hypotensive effect
may have an increased hypotensive effect when combined with hypotension-associated agents
may have an increased hypotensive effect when combined with hypotension-associated agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may increase the hypotensive effect of hypotensive agents
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
hypotensive agents increase the efficacy of duloxetine
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
hypotensive agents increase the blood pressure-lowering effect of nitroprusside
it increases the efficacy of hypotensive agents
may increase the hypotensive effect
may increase the hypotensive effect of blood pressure-lowering agents
may increase the hypotensive effect of blood pressure-lowering agents
eprosartan/hydrochlorothiazide
may increase the hypotensive effect of blood pressure-lowering agents
may increase the hypotensive effect of blood pressure-lowering agents
may increase the hypotensive effect of Blood Pressure Lowering Agents
may increase the hypotensive effect of Blood Pressure Lowering Agents
may have an increased hypotensive effect when combined with hypotensive agents
may have an increased hypotensive effect when combined with hypotensive agents
blood viscosity-reducing agents: they may increase the hypotensive effect when combined with hypotension-associated agents
blood viscosity-reducing agents: they may increase the hypotensive effect when combined with hypotension-associated agents
may enhance the QTc-prolonging effect of each other when combined
they increase the effect of hypotension of BP-lowering agents
they increase the effect of hypotension of BP-lowering agents
they increase the effect of hypotension of BP-lowering agents
they increase the effect of hypotension of BP-lowering agents
they increase the effect of hypotension of BP-lowering agents
it increases the effect of BP-lowering agents
it decreases the effect of hypotension of blood pressure lowering agents
blood pressure lowering agents increase the effect of hypotension of antipsychotic agents
blood pressure lowering agents increase the effect of hypotension of antipsychotic agents
blood pressure lowering agents increase the effect of hypotension of antipsychotic agents
blood pressure lowering agents increase the effect of hypotension of antipsychotic agents
blood pressure lowering agents increase the effect of hypotension of antipsychotic agents
it increases the effect of hypotension of blood pressure lowering agents
it increases the effect of hypotension of blood pressure lowering agents
it increases the effect of hypotension of blood lowering agents
blood pressure lowering agents increase the effect of hypotension of amifostine
it increases the effect of hypotension of BP-lowering agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
may have an increased bradycardic effect when combined with other hypotensive agents
it increases the effect of hypotension of blood lowering agents
Actions and Spectrum
efonidipine blocks L-type calcium channels, which are primarily located in the smooth muscle cells of blood vessels and the heart.
It reduces contractility and causes vasodilation of arterial vessels. This dilation of blood vessels decreases peripheral vascular resistance and subsequently lowers blood pressure.
Frequency not defined
Headache
Hot flushes
Palpitations
Flushing of face
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
efonidipine causes relaxation of vascular smooth muscle, particularly in arterial vessels. This vasodilation reduces peripheral vascular resistance, which is the main contributor to its antihypertensive effect.
It results in a reduction in blood pressure by making it easier for blood to flow through dilated blood vessels.
Pharmacodynamics
efonidipine is classified as a dihydropyridine calcium channel blocker (CCB). It blocks L-type calcium channels. These channels are found in the smooth muscle cells of both blood vessels and the heart.
Pharmacokinetics
Absorption
efonidipine is well absorbed after oral intake.
Distribution
efonidipine is distributed throughout the body.
Metabolism
efonidipine is primarily metabolized in the liver.
Elimination and excretion
efonidipine are excreted through the bile and feces.
Administration
efonidipine is taken orally in the form of tablets.
Patient information leaflet
Generic Name: efonidipine
Why do we use efonidipine?
efonidipine is used in treatment of hypertension.
efonidipine is used in management of chronic stable angina.
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