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Brand Name :
ENKAID
Synonyms :
encainide
Class :
Antiarrhythmic agents
Brand Name :
ENKAID
Synonyms :
encainide
Class :
Antiarrhythmic agents
Dosage forms and strengths Â
Capsule, gelatin-coatedÂ
25 mgÂ
Indicated for cardiac arrhythmia
Take 25 mg orally as starting dose
Not indicatedÂ
Refer adult dosingÂ
it may diminish the metabolism when combined with azelastine
it may diminish the metabolism when combined with tiotropium
When indisulam is used together with encainide, this leads to a reduction in encainide metabolism
When encainide is used together with abatacept, this leads to a rise in the encainide’s metabolism
When encainide is used together with adalimumab, this leads to a rise in the encainide’s metabolism
When encainide is used together with azelastine, this leads to a rise in the encainide’s metabolism
When encainide is used together with benzocaine, this leads to a rise in the encainide’s metabolism
When encainide is used together with berotralstat, this leads to a rise in the encainide’s metabolism
When encainide is used together with biperiden, this leads to a rise in the encainide’s metabolism
When encainide is used together with bupivacaine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with buprenorphine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with buspirone, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cannabidiol, this leads to a reduction in the encainide’s metabolism
When encainide is used together with celecoxib, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cerivastatin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cevimeline, this leads to a reduction in the encainide’s metabolism
chloroquine When encainide is used together with chloroquine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with chlorpheniramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with chlorpromazine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with chlorzoxazone, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cimetidine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cinacalcet, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cisapride, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cobicistat, this leads to a reduction in the encainide’s metabolism
When encainide is used together with codeine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with curcumin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with cyclosporine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with darifenacin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with darunavir, this leads to a reduction in the encainide’s metabolism
When encainide is used together with delavirdine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with desipramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with dexfenfluramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with dexmedetomidine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with dextromethorphan, this leads to a reduction in the encainide’s metabolism
When encainide is used together with dextropropoxyphene, this leads to a reduction in the encainide’s metabolism
When encainide is used together with diacerein, this leads to a reduction in the encainide’s metabolism
When encainide is used together with diphenhydramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with donepezil, this leads to a reduction in the encainide’s metabolism
When encainide is used together with dosulepin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with doxazosin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with doxorubicin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with dronabinol, this leads to a reduction in the encainide’s metabolism
When encainide is used together with duloxetine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with eletriptan, this leads to a reduction in the encainide’s metabolism
When encainide is used together with ethambutol, this leads to a reduction in the encainide’s metabolism
When encainide is used together with everolimus, this leads to a reduction in the encainide’s metabolism
When encainide is used together with fenfluramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with fluphenazine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with fluvastatin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with fluvoxamine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with fusidic acid, this leads to a reduction in the encainide’s metabolism
When encainide is used together with gefitinib, this leads to a reduction in the encainide’s metabolism
When encainide is used together with imipramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with ketoconazole, this leads to a reduction in the encainide’s metabolism
When encainide is used together with lansoprazole, this leads to a reduction in the encainide’s metabolism
When encainide is used together with lisuride, this leads to a reduction in the encainide’s metabolism
When encainide is used together with lorcaserin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with lovastatin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with lumefantrine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with meclizine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with mephenytoin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with mepyramine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with methadone, this leads to a reduction in the encainide’s metabolism
When encainide is used together with methimazole, this leads to a reduction in the encainide’s metabolism
When encainide is used together with metoclopramide, this leads to a reduction in the encainide’s metabolism
When encainide is used together with miconazole, this leads to a reduction in the encainide’s metabolism
When encainide is used together with minaprine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with moclobemide, this leads to a reduction in the encainide’s metabolism
When encainide is used together with nefazodone, this leads to a reduction in the encainide’s metabolism
When encainide is used together with nevirapine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with niacin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with orphenadrine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with oxybutynin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with oxycodone, this leads to a reduction in the encainide’s metabolism
When encainide is used together with oxymorphone, this leads to a reduction in the encainide’s metabolism
When encainide is used together with palonosetron, this leads to a reduction in the encainide’s metabolism
When encainide is used together with paroxetine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with perphenazine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with phenformin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with phenytoin, this leads to a reduction in the encainide’s metabolism
When encainide is used together with piperazine, this leads to a reduction in the encainide’s metabolism
When encainide is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
Actions and Spectrum:Â
ActionÂ
Sodium Channel Blockade: encainide exerts its primary antiarrhythmic effect by blocking sodium channels in cardiac cells, particularly atria and ventricles. This sodium channel blockade reduces the rate of phase 0 depolarization in cardiac cells, slowing down the propagation of action potentials.Â
SpectrumÂ
Suppression of Ventricular Arrhythmias: encainide was used to treat certain ventricular arrhythmias, particularly premature ventricular contractions (PVCs) and ventricular tachycardia. It could reduce the frequency and severity of these arrhythmias in some patients.Â
Suppression of Atrial Arrhythmias: encainide also had some efficacy in treating atrial arrhythmias, such as atrial fibrillation and atrial flutter.Â
Frequency not defined Â
Weakness Â
FeverÂ
Abdominal painÂ
DizzinessÂ
palpitationsÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: Individuals with a known hypersensitivity or allergy to encainide or any of its components should not use this medication.Â
History of Proarrhythmia: encainide can worsen or induce new, life-threatening arrhythmias. Patients with a history of proarrhythmia should avoid its use.Â
Structural Heart Disease: Individuals with structural heart disease, such as cardiomyopathy or severe coronary artery disease, are at an increased risk of experiencing proarrhythmic effects from encainide and should generally not use it.Â
Severe Heart Failure: encainide can depress cardiac contractility, and its use is generally contraindicated in patients with severe congestive heart failure.Â
Pregnancy and Breastfeeding: The safety of encainide during pregnancy and breastfeeding is not well established. Evaluating potential risks to the developing fetus or nursing baby should be balanced with the advantages of administering the substance to pregnant or lactating women.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: encainide belongs to the class of antiarrhythmic drugs known as class Ic antiarrhythmics.Â
Pharmacodynamics:Â Â
The primary pharmacodynamic effect of encainide is its ability to block sodium channels in cardiac myocytes, leading to a decrease in the rate of depolarization and conduction velocity.Â
This action can help to reduce abnormal electrical activity in the heart, making it useful for treating certain arrhythmias, particularly ventricular arrhythmias.Â
Pharmacokinetics:Â
AbsorptionÂ
encainide is rapidly absorbed after oral administration.Â
DistributionÂ
It is widely distributed in the body, including the heart tissue.Â
MetabolismÂ
encainide is extensively metabolized in the liver. One of its primary metabolites is O-desmethylencainide, which is pharmacologically active.Â
Excretion and EliminationÂ
Both the parent drug and its metabolites are excreted in urine.Â
Administration: Â
encainide is typically taken orally in the form of capsules or tablets. Your healthcare provider will also determine the frequency of dosing. It’s crucial to follow the prescribed dosing schedule.Â
Patient information leafletÂ
Generic Name: encainideÂ
Why do we use encainide?Â
encainide was mainly recommended for the treatment of critical ventricular arrhythmias, including conditions like ventricular tachycardia and ventricular fibrillation. It stabilized the heart’s electrical activity and prevented irregular heart rhythms. Â
encainide was sometimes used to treat atrial arrhythmias, like atrial fibrillation or atrial flutter. However, its use for this purpose was less common than for ventricular arrhythmias.Â
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