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Brand Name :
Trilipix, Fibricor
Synonyms :
fenofibric acid
Class :
Fibric Acid Agents
Brand Name :
Trilipix, Fibricor
Synonyms :
fenofibric acid
Class :
Fibric Acid Agents
Dosage Forms & StrengthsÂ
Tablet (Fibricor)Â
35mgÂ
105mgÂ
Delayed-release capsule (Trlipix)Â
45mgÂ
135mgÂ
Indicated as a supplement to diet for more than 500mg/dl for severe hypertriglyceridemia
Fibricor- 35-105 mg orally each day
Trilipix- 45-135 mg orally each day
Indicated as a supplement to the diet to decrease the high levels of Total-C, TG, and Apo B and LDL-C
Also, it is indicated to increase the HDL-C in patients who have mixed dyslipidemia or primary Fibricor- 105 mg orally each day
Trilipix- 135 mg orally each day
Dose Modification
For mild to moderate renal impairment, start with the lower dose available, and increase the dose only after evaluation of lipid and renal levels
Safety and efficacy are not seen in pediatricsÂ
Refer to the adult dosingÂ
may diminish the absorption when combined with fibric acid derivatives
may increase the nephrotoxic effect of cyclosporine
may diminish the absorption when combined with fibric acid derivatives
it increases the toxicity of fibric derivatives
fibric acid derivatives increase the toxicity of ezetimibe
It may enhance toxicity when combined with cholic acid by diminishing the elimination
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may enhance the myopathic effect of colchicine
may increase the hypoglycemic effect of sulfonylureas
may increase the myopathic effect of Fibric Acid Derivatives
it increases the effect of myopathy on fibric acid derivatives
fibric acid derivatives increase the effect of hypoglycemia of sulfonylureas
fibric acid derivatives increase the effect of hypoglycemia of sulfonylureas
fibric acid derivatives increase the effect of hypoglycemia of sulfonylureas
fibric acid derivatives increase the effect of hypoglycemia of sulfonylureas
fibric acid derivatives increase the effect of hypoglycemia of sulfonylureas
It may enhance the risk of adverse effects when combined with Atypical Antidepressants
It may enhance the risk of adverse effects when combined with Atypical Antidepressants
It may enhance the risk of adverse effects when combined with Atypical Antidepressants
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
Actions and Spectrum:Â
Frequency definedÂ
>10%Â
HeadacheÂ
1-10%Â
NauseaÂ
Back PainÂ
NasopharyngitisÂ
MyalgiaÂ
DiarrheaÂ
Increased CPKÂ
Increased ALTÂ
Increased ASTÂ
Contraindication/Caution:Â
fenofibric acid is generally considered safe and well-tolerated, but specific contraindications and precautions should be considered. These include:Â
Pregnancy consideration:Â Â
Limited data are available for adverse effects or congenital disabilities in the fetus due to medication in pregnant women.Â
Breastfeeding warnings:Â Â
Information about the excretion of drugs in the breastmilk is unknownÂ
Pregnancy category:Â
Pharmacology:Â
fenofibric acid is a medication used to lower triglycerides and cholesterol levels in the blood. Â
fenofibric acid works by activating PPAR-alpha, a nuclear receptor that regulates gene expression in lipid metabolism. Activation of PPAR-alpha leads to increased breakdown and clearance of triglycerides and very low-density lipoprotein (VLDL) cholesterol, which can help reduce triglyceride levels and other lipids in the blood.Â
Pharmacodynamics:Â
The pharmacodynamics of fenofibric acid involves its interaction with peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the liver and other tissues. Here is a brief overview of the pharmacodynamics of fenofibric acid:Â
Pharmacokinetics:Â
AbsorptionÂ
The bioavailability is 81% (for Trilipix)Â
The peak plasma concentration is achieved in 4-5 hours (for Trilipix) and 2.5 hours (for Fibricor)Â
DistributionÂ
Steady-state is achieved in 8 days (for Trilipix) and 9 days (for Fibricor)Â
The protein-bound is 99%Â
MetabolismÂ
The drug gets primarily conjugated with glucuronic acid.Â
A small carbonyl moiety is reduced to benzhydrol metabolite, which, in turn, conjugates with glucuronic acid.Â
Elimination and ExcretionÂ
The half-life is 20 hoursÂ
The drug gets excreted in the urine as fenofibric acid glucuronide and fenofibric acid Â
Administration:Â
fenofibric acid is usually administered orally as a tablet or capsule, with or without food. Â
In an overdose, patients should seek medical attention immediately. Overdose symptoms include abdominal pain, vomiting, nausea, and diarrhea.Â
Patient information leafletÂ
Generic Name: fenofibric acid Â
Pronounced: FEN-oh-FYE-brik-AS-id Â
Why do we use fenofibric acid?Â
fenofibric acid is primarily used to lower triglyceride and cholesterol levels in the blood. Specific uses of fenofibric acid are:Â
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