Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Fucidin
Synonyms :
fusidic acid
Class :
Antibiotic
Brand Name :
Fucidin
Synonyms :
fusidic acid
Class :
Antibiotic
Dosage Forms & StrengthsÂ
Tablet-sodium fusidateÂ
250mgÂ
500mg Â
SuspensionÂ
250mg/5mlÂ
Indicated for Susceptible staphylococcal infections such as osteomyelitis, septicemia, endocarditis, superinfected cystic fibrosis, cutaneous infections, pneumonia, and wound infections
:
Tablets-Administer 250mg twice a day or 500 to 1000mg thrice a day
Suspension-750 to 1000mg thrice a day
Dosage Forms & StrengthsÂ
Tablet-sodium fusidateÂ
250mgÂ
500mgÂ
SuspensionÂ
250mg/5mlÂ
Indicated for Susceptible staphylococcal infections such as osteomyelitis, septicemia, endocarditis, superinfected cystic fibrosis, cutaneous infections, pneumonia, wound infections
:
<1 year old:
Suspension-Administer 50 mg/kg/day divided thrice a day
1 to 5 years old:
Suspension-Administer 250mg thrice a day
>5 to 12 years old:
Tablets-Administer 250 to 500 mg thrice a day
Suspension-500 to 1000mg thrice a day
Refer adult dosingÂ
may enhance the serum concentration of Ergot Derivatives
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of alfentanil in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
may enhance the serum concentration when combined with CYP3A4 substrates
may enhance the concentration of serum when combined with CYP3A4 substrates
fusidic acid: they may enhance the serum concentration of CYP3A inhibitors
fusidic acid: they may enhance the serum concentration of CYP3A inhibitors
fusidic acid: they may enhance the serum concentration of CYP3A inhibitors
fusidic acid: they may enhance the serum concentration of CYP3A inhibitors
fusidic acid: they may enhance the serum concentration of CYP3A inhibitors
may increase the serum concentration of CYP3A4 substrates
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
it increases the concentration of CYP3A4 substrates in serum
hydrocodone/​chlorpheniramine/​pseudoephedrineÂ
may enhance the serum concentration of CYP3A4 substrates
may enhance the serum concentration of CYP3A4 substrates
may increase the serum concentration of CYP3A4 substrates
may increase the serum concentration of CYP3A4 substrates
azelastine/fluticasone intranasalÂ
may enhance the serum concentration
may enhance the serum concentration of CYP3A4 substrates
may enhance the serum concentrations of CYP3A4 substrates
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may increase the serum concentration of CYP3A4 Substrates
may increase the adverse effect of HMG-CoA Reductase Inhibitors
may increase the serum concentration of CYP3A4 Substrates
may enhance the serum concentration of CYP3A4 Substrates
may enhance the serum concentration of CYP3A4 substrates
When alprazolam and fusidic acid is used together, this leads to reduction in the alprazolam’s metabolism
When encainide is used together with fusidic acid, this leads to a reduction in the encainide’s metabolism
When fusidic acid is used together with adenine, this leads to a reduction in the fusidic acid metabolism
may enhance the serum levels of CYP3A4 substrates
may enhance the serum levels of CYP3A4 substrates
may enhance the serum levels of CYP3A4 substrates
may enhance the serum levels of CYP3A4 substrates
it may increase the plasma concentration of CYP3A4 substrates
may decrease the therapeutic effect of each other when combined
Actions and Spectrum:Â
fusidic acid is a narrow-spectrum antibiotic that is mainly used to treat infections caused by bacteria such as Staphylococcus aureus and Streptococcus species. It works by inhibiting bacterial protein synthesis, specifically by binding to elongation factor G (EF-G) and preventing the release of ribosomes from mRNA during translation. This leads to the inhibition of bacterial protein synthesis and ultimately results in the death of the bacteria.Â
fusidic acid is a bacteriostatic antibiotic, meaning that it slows down the growth and replication of bacteria rather than killing them outright. It is effective against Gram-positive bacteria, including many strains of Staphylococcus aureus resistant to other antibiotics.Â
fusidic acid is mainly used to treat skin and soft tissue infections, such as impetigo, dermatitis, and infected wounds. It is also used with other antibiotics to treat more severe infections, such as osteomyelitis, endocarditis, and pneumonia.Â
Contraindications/caution:Â
Contraindications:Â
Caution:Â
fusidic acid should be used with caution in the following situations:Â
Pregnancy consideration: fusidic acid should not be used during pregnancy unless the potential benefits outweigh the potential risks to the fetusÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
fusidic acid is an antibiotic that belongs to the class of steroidal compounds known as fusidanes. It selectively inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) and preventing the release of ribosomes from mRNA during translation. This leads to the inhibition of bacterial protein synthesis and ultimately results in the death of the bacteria.Â
fusidic acid is effective against Gram-positive bacteria, including many Staphylococcus aureus strains resistant to other antibiotics. It has a relatively narrow spectrum of activity and is ineffective against Gram-negative bacteria.Â
fusidic acid is rapidly absorbed after oral administration and is distributed widely throughout the body, including into skin and soft tissues. It is highly protein-bound and is primarily metabolized by the liver and excreted in the urine.Â
Pharmacodynamics:Â
fusidic acid exhibits concentration-dependent killing, meaning that higher concentrations of the drug result in more significant bacterial killing. It has a post-antibiotic effect, which means bacterial growth may be suppressed even after the drug is no longer present.Â
Resistance to fusidic acid can occur through mutations in the EF-G target site or other genes involved in the drug’s mode of action. Cross-resistance with other antibiotics is rare, and the development of resistance to fusidic acid is generally slow.Â
Pharmacokinetics:Â
AbsorptionÂ
fusidic acid is a lipophilic compound rapidly and almost completely absorbed after oral administration. Â
DistributionÂ
It is highly protein-bound (approximately 99%) and has a large volume of distribution, indicating extensive tissue distribution.Â
MetabolismÂ
The liver primarily metabolizes fusidic acid, with most of the drug being eliminated in the feces via biliary excretion. Only a tiny fraction of the drug is eliminated in the urine, indicating that renal excretion plays a minor role in eliminating fusidic acid.Â
Elimination and ExcretionÂ
The elimination half-life of fusidic acid is relatively short, ranging from 3 to 6 hours, depending on the dose and route of administration. As a result, the drug must be administered multiple times daily to maintain therapeutic levels in the body.Â
Administration:Â
fusidic acid can be administered by various routes, including oral, topical, and intravenous (IV) routes. The specific route of administration depends on the indication and severity of the infection being treated.Â
Patient information leafletÂ
Generic Name: fusidic acidÂ
Why do we use fusidic acid?Â
fusidic acid is primarily used to treat soft tissue and skin and infections caused by susceptible bacteria, such as Streptococcus pyogenes and Staphylococcus aureus. Some of the specific conditions that may be treated with fusidic acid include:Â
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