Effectiveness of Tai Chi vs Cognitive Behavioural Therapy for Insomnia in Middle-Aged and Older Adults
November 27, 2025
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Brand Name :
Seizalam
Synonyms :
midazolam
Class :
Antianxiety Agents, Benzodiazepines, Anticonvulsants
Brand Name :
Seizalam
Synonyms :
midazolam
Class :
Antianxiety Agents, Benzodiazepines, Anticonvulsants
Dosage Forms & StrengthsÂ
SyrupÂ
2mg/mlÂ
Injectable solutionÂ
1mg/mlÂ
5mg/mlÂ
300 - 350
mcg/kg
Solution
Intravenous (IV)
0.5 - mi
minute
Dosage Forms & StrengthsÂ
SyrupÂ
2mg/mlÂ
injectable solutionÂ
1mg/mlÂ
5mg/mlÂ
2
Solution
Intravenous (IV)
50 - 150
mcg/kg
Solution
Intravenous (IV)
20 - 30
minutes
Use Of Procedural Sedation In The Operating RoomÂ
20 - 50
mcg/kg
Solution
Intramuscular (IM)
midazolam: they may enhance the serum concentration of CYP3A Inhibitors
midazolam: they may enhance the serum concentration of CYP3A Inhibitors
The interaction may increase the risk of sedation, respiratory depression, and coma
may enhance the CNS depressant effect
may increase the depressant effect of opioid agonists
may increase the CNS depressant effect
the effect of midazolam is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of midazolam 
it increases the effect of CNS depressants
may increase the CNS depressant effect
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the concentration of serum when combined with midazolam
may enhance the concentration of serum when combined with midazolam
may enhance the concentration of serum when combined with midazolam
may enhance the concentration of serum when combined with midazolam
may enhance the concentration of serum when combined with midazolam
midazolam: they may diminish the serum concentration of CYP3A4 Inducers
midazolam: they may diminish the serum concentration of CYP3A4 Inducers
midazolam: they may diminish the serum concentration of CYP3A4 Inducers
midazolam: they may diminish the serum concentration of CYP3A4 Inducers
midazolam: they may diminish the serum concentration of CYP3A4 Inducers
It may enhance toxicity when combined with cholic acid by diminishing the elimination
midazolam: they may enhance the serum concentration of CYP3A Inhibitors
midazolam: they may enhance the serum concentration of CYP3A Inhibitors
When midazolam is used together with ridaforolimus, this leads to enhanced concentration serum of midazolam
CYP3A4 inhibitors increase the concentration of midazolam in serum
CNS Depressants may enhance the CNS depressant effect of brexanolone
CNS depressants may enhance the sedative effect of rotigotine
may enhance the CNS depressant effect of cannabinoid-containing products
may enhance the CNS depressant effect of cannabinoid-containing products
may enhance the serum concentration of CYP3A4 inhibitors
the drug midazolam has sedative effects, as does melatonin hence both enhance sedation
may enhance the serum concentration of CYP3A4 Inhibitors
may increase the CNS depressant effect of CNS Depressants
asunaprevir will decrease serum concentration of midazolam
it increases the effect of CNS depressants
Action and Spectrum:Â
Midazolam acts as GABA receptor. It causes new memory formation prevention to help in surgeries and diagnostic procedures for patients.Â
Adverse reaction:Â
>10%Â
Decreased respiratory rateÂ
ApneaÂ
1-10%Â
Drowsiness Â
CoughÂ
Seizure-like activityÂ
Pain at injection siteÂ
Frequency Not DefinedÂ
HeadacheÂ
DeliriumÂ
EuphoriaÂ
SedationÂ
HiccoughsÂ
Black box warning:Â
Do not administer with rapid intravenous injection in neonates.Â
Use only in monitored settings for respiratory and cardiac function monitoring.Â
Contraindications:Â
HypersensitivityÂ
Cautions:Â
Elderly and Debilitated PatientsÂ
Patients with Chronic Respiratory InsufficiencyÂ
Impaired Renal FunctionÂ
Pregnancy Warnings:Â
Pregnancy category: N/AÂ
Lactation: Excretion of the drug into the human breast milk is knownÂ
Pregnancy categories:Â
Pharmacology: Midazolam helps to calm preoperative patients and during distressing procedures. It causes muscle relaxation from central nervous system impact and secondary effect.Â
Pharmacodynamics: GABA-mediated channels increase chloride ion permeability leads to hyperpolarization and stabilization of neuronal membrane.Â
Pharmacokinetic:Â
Absorption:Â
It shows peak plasma concentration of 90 mg/ml for intramuscular route.Â
It has bioavailability up to 40% to 50% for oral and >90% for intramuscular route.Â
Distribution:Â
It shows protein bound of 97%.Â
Metabolism:Â
It metabolized in liver with CYP3A4 pathway.Â
Excretion and elimination:Â
It is excreted through urinary route.Â
Administration:Â
It is available in syrup and solution form.
Patient information leaflet:Â
Generic Name: midazolamÂ
Why do we use midazolam?Â
Midazolam is used in induction and maintenance of anesthesia during long surgical procedures.Â
It is used in amnesia to prevent the formation of traumatic memories.Â
It is used in sedation of intubated and mechanical ventilated patients to ensure comfort and compliance with ventilation.Â
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