Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
olinvyk
Synonyms :
oliceridine
Class :
Opioids (Narcotics & Analgesics)
Brand Name :
olinvyk
Synonyms :
oliceridine
Class :
Opioids (Narcotics & Analgesics)
Dosing forms and strengthsÂ
Solution for Injection(Single dose vial)Â
1 mg/mLÂ
2 mg/2 mLÂ
Indicated for moderate to severe acute pain
Initial dose: Administer 1.5 mg of oliceridine intravenously
Supplemental dose: Administer 0.75 mg of oliceridine intravenously every hour as needed, starting 1 hour after the initial dose
Maximum single dose: The maximum recommended single dose of oliceridine is 3 mg
Maximum daily dose: The maximum recommended daily dose of oliceridine is 27 mg
Safety and efficacy are not well established
CYP3A strong enhancers of the small intestine may reduce the bioavailability of oliceridine 
oliceridine: they may enhance the serum concentration of CYP3A4 Inhibitors
oliceridine: they may enhance the serum concentration of CYP3A4 Inhibitors
oliceridine: they may enhance the serum concentration of CYP3A4 Inhibitors
oliceridine: they may enhance the serum concentration of CYP3A4 Inhibitors
oliceridine: they may enhance the serum concentration of CYP3A4 Inhibitors
oliceridine: they may enhance the serum concentration of CYP2D6 Inhibitors
oliceridine: they may enhance the serum concentration of CYP2D6 Inhibitors
oliceridine: they may enhance the serum concentration of CYP2D6 Inhibitors
oliceridine: they may enhance the serum concentration of CYP2D6 Inhibitors
oliceridine: they may enhance the serum concentration of CYP2D6 Inhibitors
When abametapir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When abiraterone is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When amiodarone is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When amprenavir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When aprepitant is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When asunaprevir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When berotralstat is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When boceprevir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When celecoxib is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When chloroquine is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When cholecalciferol is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When cimetidine is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When cinacalcet is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When ciprofloxacin is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When clarithromycin is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When cobicistat is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When conivaptan is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When crizotinib is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When curcumin is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When cyclosporine is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When dacomitinib is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When danazol is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When darifenacin is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When darunavir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
When acebutolol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When adagrasib is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When alogliptin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When aminophenazone is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When antipyrine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When arformoterol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When atenolol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When atomoxetine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When bepridil is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When betaxolol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When bortezomib is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When carvedilol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When celiprolol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When cevimeline is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When cilostazol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When cinnarizine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When dapagliflozin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When debrisoquine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When deutetrabenazine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When diacerein is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When dicloxacillin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When dimethyl sulfoxide is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When domperidone is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When doxazosin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When doxorubicin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When elagolix is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When encainide is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When esmolol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When ethambutol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When etoricoxib is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When everolimus is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When felodipine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When fexinidazole is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When fluvastatin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When formoterol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When galantamine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When gefitinib is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When hydroxychloroquine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When ibrutinib is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When idarubicin is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When labetalol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When levobetaxolol is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
When lorpiprazole is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
the effect of oliceridine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increase in the serum concentration of oliceridine
CYP3A4 inhibitors increase the concentration of oliceridine in serum
When atazanavir is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
Actions and Spectrum:Â
It is an opioid agent that is used to treat pain and the exact mechanism of action is unknown.Â
Frequency DefinedÂ
HypoxiaÂ
NauseaÂ
ConstipationÂ
PruritusÂ
Back painÂ
SedationÂ
VomitingÂ
SomnolenceÂ
Blackbox warningÂ
It carries a serious warning about potential life-threatening effects. It has a high risk of suppressing breathing, which could be harmful. It can lead to addiction, resulting in the physical and emotional dependence.Â
Contraindication/Caution:Â
Hypersensitivity reactionsÂ
Bronchial AsthmaÂ
Paralytic IleusÂ
Respiratory depressionÂ
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation:Â Excreted into human milk is unknown
Pregnancy Categories:Â Â Â Â Â Â Â
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacology:Â
It is a selective mu-opioid receptor agonist which binds to the brain and spinal cord and activating it to relieve pain.Â
PharmacokineticsÂ
AbsorptionÂ
After the initial dose Onset of Action will be 2 to 5 minutesÂ
DistributionÂ
Volume of distribution: 90 to 120 litresÂ
MetabolismÂ
The drug is metabolized into inactive forms by hepatic metabolismÂ
Elimination/ExcretionÂ
Elimination half-life is 1.3 to 3 hoursÂ
Majority(77%) of the drug is excreted through urineÂ
AdministrationÂ
Intravenous administration is suggestedÂ
Patient information leaflet:Â
Generic Name: oliceridineÂ
Why do we use oliceridine?Â
It belongs to the class of opioid agonists used in the management of Acute pain.Â
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