What Happens When You’re Just Mind Blanking
December 27, 2025
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Brand Name :
navane
Synonyms :
thiothixene
Class :
1st generation Anti Psychotics
Brand Name :
navane
Synonyms :
thiothixene
Class :
1st generation Anti Psychotics
Dosage Forms & Strengths
Capsule
1mg
2mg
5mg
10mg
Mild to Moderate:
Initial dose-2 mg orally thrice a day
Maintenance dose-15 mg per day orally once
Severe:
Initial dose-5 mg orally twice a day
Maintenance dose-20 to 30 mg per day orally once
Do not exceed 60 mg per day orally twice or thrice a day
Dosage Forms & Strengths
Capsule
1mg
2mg
5mg
10mg
<12 years:
Safety and efficacy not established
>12 years:
Mild to Moderate:
Initial dose-2 mg orally thrice a day
Maintenance dose-15 mg per day orally once
Severe:
Initial dose-5 mg orally twice a day
Maintenance dose-20 to 30 mg per day orally once
Do not exceed 60 mg per day
<12 years:
Safety and efficacy not established
>12 years:
Mild to Moderate:
Initial dose-2 mg orally thrice a day
Maintenance dose-15 mg per day orally once
Severe:
Initial dose-5 mg orally twice a day
Maintenance dose-20 to 30 mg per day orally once
Do not exceed 60 mg per day
Refer adult dosing
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may increase the CNS depressant effect of CNS depressants
may decrease the anti-psychotic therapeutic effect
may decrease the anti-psychotic therapeutic effect
may decrease the anti-psychotic therapeutic effect
may decrease the anti-psychotic therapeutic effect
may decrease the anti-psychotic therapeutic effect
may increase the CNS depressant effect of CNS depressants
may increase the constipating effect of anticholinergic agents
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
It may enhance the QTc interval when combined with efavirenz
may increase the toxic effect of antipsychotic agents
may increase the toxic effect of antipsychotic agents
may increase the toxic effect of antipsychotic agents
may increase the toxic effect of antipsychotic agents
may increase the toxic effect of antipsychotic agents
may increase the toxic effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect of anticholinergic agents
may increase the toxic effect of CNS depressants
may increase the toxic effect of CNS depressants
may increase the toxic effect of CNS depressants
may increase the toxic effect of CNS depressants
may increase the toxic effect of CNS depressants
may increase the toxic effect of seizure threshold-lowering potential agents
may increase the toxic effect of seizure threshold-lowering potential agents
may increase the toxic effect of seizure threshold-lowering potential agents
may increase the toxic effect of seizure threshold-lowering potential agents
may increase the toxic effect of seizure threshold-lowering potential agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
may increase the toxic effect of antipsychotics
It may diminish the effects when combined with chasteberry by pharmacodynamic antagonism
it may increase the risk of adverse effects of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
Actions and Spectrum:
Frequency not defined
Decreased sweating
EPS ( muscle stiffness, dystonia, Parkinsonism, tardive dyskinesia, akathisia) (60%)
Orthostatic hypotension
Weight gain
Agitation
Allergic reactions
Anorexia
Constipation
Drowsiness
Increased appetite
Photosensitivity
Xerostomia
Allergic dermatitis
Anticholinergic effects
Cerebral edema
Dizziness
Euphoria
Ileus
Irregular menses
Anxiety
Depression
Erectile dysfunction
Headache
Insomnia
Black box warning:
thiothixene, like other antipsychotic medications, carries a black box warning for increased mortality risk in elderly patients with dementia-related psychosis.
Elderly patients with dementia who are treated with antipsychotic medications such as thiothixene may be at an increased risk of death, particularly when these drugs are used for extended periods.
Contraindications/caution:
Contraindications:
Caution:
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
thiothixene is a first-generation anti-psychotic medication that blocks the binding of dopamine to its receptors in the brain. Specifically, thiothixene has a high affinity for D2 and D1 dopamine receptors and alpha-adrenergic and histaminergic receptors.
This leads to a decrease in dopamine activity in the brain’s mesolimbic pathway, which is thought to be responsible for the positive symptoms of schizophrenia, such as delusions and hallucinations.
thiothixene also has a moderate affinity for serotonin receptors, which may contribute to its efficacy in treating the negative symptoms of schizophrenia, such as apathy and social withdrawal.
Pharmacodynamics:
The pharmacodynamics of thiothixene involve its interaction with specific receptors in the brain and the effects on neurotransmitter activity. thiothixene is primarily a dopamine receptor antagonist, which blocks the binding of dopamine to its receptors in the brain. By blocking dopamine activity in the brain’s mesolimbic pathway, thiothixene is thought to reduce the positive symptoms of schizophrenia, such as delusions and hallucinations.
Pharmacokinetics:
Absorption
thiothixene is well-absorbed after oral administration, with peak plasma concentrations occurring within 2 to 4 hours. Food can delay thiothixene absorption, so taking the medication on an empty stomach is typically recommended.
Distribution
thiothixene is highly protein-bound (over 95%) and has a large volume of distribution, indicating that it distributes extensively throughout the body. The medication crosses the blood-brain barrier and can affect dopamine receptors in the brain.
Metabolism
thiothixene undergoes extensive metabolism in the liver, primarily by the cytochrome P450 enzyme system. The major metabolite of thiothixene is 9-hydroxythiothixene, which is also active. thiothixene has a half-life of approximately 24 hours.
Elimination and Excretion
thiothixene and its metabolites are excreted in the urine and feces. About 20% to 30% of the administered dose is excreted in the urine as an unchanged drug, and approximately 50% is excreted in the feces
Administration:
thiothixene is available in several forms for oral administration, including capsules and tablets. The medication is typically taken once or twice daily, depending on the individual’s symptoms, response to treatment, and other medical conditions.
thiothixene should be taken on an empty stomach, as food can delay absorption. The medication should be swallowed whole with water or another non-alcoholic beverage. The dosage of thiothixene may need to be adjusted over time to achieve optimal therapeutic effects while minimizing side effects.
Patient information leaflet
Generic Name: thiothixene
Why do we use thiothixene?
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