Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Bifril, Zofenil
Synonyms :
zofenopril
Class :
ACE Inhibitors
Brand Name :
Bifril, Zofenil
Synonyms :
zofenopril
Class :
ACE Inhibitors
Dosage Forms & StrengthsÂ
tabletÂ
30 mgÂ
7.5 mg is given orally every 12 hours for 2 days, followed by 15 mg is given every 12 hours for next 2 days, and followed by 30 mg is given every 12 hours for more than 6 weeks
7.5 to 30 mg given initially once a day (maximum dose: 60 mg daily as a single dose or in the two divided doses)
Safety and efficacy were not establishedÂ
Refer to the adult dosing regimenÂ
may increase the adverse effect of angiotensin ii receptor blockers
may increase the adverse effect of angiotensin ii receptor blockers
may increase the toxic effect of angiotensin receptor II blockers
may enhance the hypotensive effect when combined with sparsentan
may diminish the serum concentration when combined with angiotensin-converting enzyme inhibitors
may have an increased hyperkalemic effect when combined with ACE inhibitors
may increase the adverse/toxic effect of angiotensin ii receptor blockers
may increase the adverse/toxic effect of angiotensin ii receptor blockers
may increase the adverse/toxic effect of angiotensin ii receptor blockers
may increase the adverse/toxic effect of angiotensin ii receptor blockers
may increase the adverse/toxic effect of angiotensin ii receptor blockers
when clonidine is used in combination with zofenopril, there is an increase in risk or severity of hypotension
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
buflomedil may lessen zolofenopril's antihypertensive effects
dihydroergocristine may reduce the antihypertensive activities of zofenopril
zofenopril may increase the hypotensive activities of muzolimine
may have an increasingly adverse effect when combined with NSAIDs
when prenylamine is combined with zofenopril, there is an increased risk or severity of hyperkalemia
may increase the hypotensive effect of angiotensin-converting enzyme inhibitors
may increase the hypotensive effect of angiotensin-converting enzyme inhibitors
may increase the hypotensive effect of angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with NSAIDs
ACE Inhibitors may enhance the potential for allergic or hypersensitivity reactions to allopurinol
angiotensin-converting Enzyme (ACE) inhibitors may increase the risk of adverse effects of alteplase
icatibant may reduce the antihypertensive effect of ACE inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may increase the nephrotoxic effect of salicylates
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
drospirenone/ethinyl estradiol/levomefolateÂ
may increase the hyperkalemic effect of Drospirenone-Containing Products
choline magnesium trisalicylate
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with ACE inhibitors
may have an increased hypotensive effect when combined with ACE inhibitors
may have an increased hypotensive effect when combined with ACE inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
Actions and spectrum:Â
zofenopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure. It works by relaxing blood vessels, reducing blood pressure, and improving the heart’s ability to pump blood effectively. zofenopril may also be used to protect the heart and reduce the risk of heart-related complications, especially in individuals with heart disease.Â
The spectrum of zofenopril’s action includes its ability to lower blood pressure, reduce the strain on the heart, and provide cardiovascular protection, which makes it valuable in the management of various heart-related conditions.Â
Frequency not definedÂ
nauseaÂ
muscle crampsÂ
dizzinessÂ
rashÂ
AngioedemaÂ
abdominal painÂ
diarrheaÂ
dry mouthÂ
vomitingÂ
constipationÂ
Black Box Warning:Â
There were no specific black box warnings associated with zofenopril.Â
Contraindication/Caution:Â
Contraindication:Â
Â
Caution:Â
Comorbidities:Â
Pregnancy consideration: pregnancy category: not assignedÂ
Lactation: excreted into human milk: unknown Â
Pregnancy category:Â
Pharmacology:Â
zofenopril is an angiotensin-converting enzyme (ACE) inhibitor, commonly used to treat hypertension and heart failure. Its pharmacology primarily involves inhibiting the ACE enzyme converts angiotensin I to angiotensin II, that can raise blood pressure. By blocking this conversion, zofenopril causes blood vessels to relax, reducing resistance to blood flow, and lowering blood pressure.
zofenopril also has cardioprotective effects by decreasing the workload on the heart and reducing stress on the cardiovascular system. This medication can be particularly beneficial for patients with comorbid conditions, such as heart failure and kidney disease, where blood pressure control and cardiovascular protection are essential components of their treatment regimen. Â
Pharmacodynamics:Â
Pharmacokinetics:Â
AbsorptionÂ
zofenopril is usually administered orally, commonly in the form of tablets. zofenopril is readily absorbed from the gastrointestinal tract after oral administration.Â
DistributionÂ
It is distributed throughout the body, including into tissues such as the heart, kidneys, and liver.Â
MetabolismÂ
zofenopril is primarily metabolized in the liver, where it undergoes oxidation and conjugation reactions.Â
Elimination and excretionÂ
zofenopril and its metabolites are eliminated from the body primarily via the kidneys. The half-life of zofenopril is short, with an average half-life of around 1 hour.Â
Administration:Â
Patient information leafletÂ
Generic Name: zofenoprilÂ
Pronounced: (zoh-FEN-oh-pril)Â Â
Why do we use zofenopril?Â
zofenopril is often prescribed to lower elevated blood pressure. By relaxing blood vessels, it reduces the resistance to blood flow, helping to decrease blood pressure. zofenopril can be used as part of the treatment for heart failure. It helps to improve the heart’s pumping ability and decrease the workload on the heart. In some cases, zofenopril may be prescribed to individuals who have had a heart attack to reduce the risk of further cardiovascular events.Â
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