Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Leukotrap, Sag-M, Rejuvesol
Synonyms :
adenin, 6-Aminopurine
Class :
Dietary supplements
Brand Name :
Leukotrap, Sag-M, Rejuvesol
Synonyms :
adenin, 6-Aminopurine
Class :
Dietary supplements
Dosage forms and strengths Â
Oral tabletÂ
10 mg Â
60 mgÂ
Indicated as Nutritional supplementation
In vivo, data suggests taking a day dose of 10 mg to 60 mg orally daily
Not indicatedÂ
Refer adult dosingÂ
When abacavir is used together with adenine, this leads to a reduction in the abacavir's metabolism
When acetaminophen is used together with adenine, this leads to a reduction in the acetaminophen's metabolism
When atorvastatin is used together with adenine, this leads to a reduction in the atorvastatin's metabolism
When axitinib is used together with adenine, this leads to a reduction in the axitinib's metabolism
When belinostat is used together with adenine, this leads to a reduction in the belinostat's metabolism
When bexagliflozin is used together with adenine, this leads to a reduction in the bexagliflozin’s metabolism
When bictegravir is used together with adenine, this leads to a reduction in the bictegravir's metabolism
When binimetinib is used together with adenine, this leads to a reduction in the binimetinib's metabolism
When buprenorphine is used together with adenine, this leads to a reduction in the buprenorphine's metabolism
When cabotegravir is used together with adenine, this leads to a reduction in the cabotegravir’s metabolism
When carvedilol is used together with adenine, this leads to a reduction in the carvedilol’s metabolism
When cerivastatin is used together with adenine, this leads to a reduction in the cerivastatin's metabolism
When darolutamide is used together with adenine, this leads to a reduction in the darolutamide's metabolism
When deferasirox is used together with adenine, this leads to a reduction in the deferasirox's metabolism
When delafloxacin is used together with adenine, this leads to a reduction in the delafloxacin's metabolism
When dexibuprofen is used together with adenine, this leads to a reduction in the dexibuprofen's metabolism
When diclofenac is used together with adenine, this leads to a reduction in the diclofenac's metabolism
When dolutegravir is used together with adenine, this leads to a reduction in the dolutegravir's metabolism
When dronabinol is used together with adenine, this leads to a reduction in the dronabinol's metabolism
When elagolix is used together with adenine, this leads to a reduction in the elagolix’s metabolism
When eltrombopag is used together with adenine, this leads to a reduction in the eltrombopag's metabolism
When elvitegravir is used together with adenine, this leads to a reduction in the elvitegravir's metabolism
When enasidenib is used together with adenine, this leads to a reduction in the enasidenib's metabolism
When eslicarbazepine is used together with adenine, this leads to a reduction in the eslicarbazepine's metabolism
When eslicarbazepine acetate is used together with adenine, this leads to a reduction in the eslicarbazepine acetate’s metabolism
When estradiol is used together with adenine, this leads to a reduction in the estradiol’s metabolism
When estradiol acetate is used together with adenine, this leads to a reduction in the estradiol acetate’s metabolism
When estradiol benzoate is used together with adenine, this leads to a reduction in the estradiol benzoate’s metabolism
When belinostat is used together with adenine, this leads to a reduction in the belinostat's metabolism
When estradiol dienanthate is used together with adenine, this leads to a reduction in the estradiol dienanthate’s metabolism
When estradiol valerate is used together with adenine, this leads to a reduction in the estradiol valerate’s metabolism
When ethinylestradiol is used together with adenine, this leads to a reduction in the ethinylestradiol ’s metabolism
When etoposide is used together with adenine, this leads to a reduction in the etoposide’s metabolism
When ezetimibe is used together with adenine, this leads to a reduction in the ezetimibe ’s metabolism
When ezogabine is used together with adenine, this leads to a reduction in the ezogabine’s metabolism
When febuxostat is used together with adenine, this leads to a reduction in the febuxostat’s metabolism
When fluvastatin is used together with adenine, this leads to a reduction in the fluvastatin’s metabolism
When fulvestrant is used together with adenine, this leads to a reduction in the fulvestrant ’s metabolism
When furosemide is used together with adenine, this leads to a reduction in the furosemide’s metabolism
When fusidic acid is used together with adenine, this leads to a reduction in the fusidic acid metabolism
When gemfibrozil is used together with adenine, this leads to a reduction in the gemfibrozil’s metabolism
When glipizide is used together with adenine, this leads to a reduction in the glipizide’s metabolism
When ibuprofen is used together with adenine, this leads to a reduction in the ibuprofen’s metabolism
When indomethacin is used together with adenine, this leads to a reduction in the indomethacin’s metabolism
When ketoprofen is used together with adenine, this leads to a reduction in the ketoprofen’s metabolism
When labetalol is used together with adenine, this leads to a reduction in the labetalol’s metabolism
When lamotrigine is used together with adenine, this leads to a reduction in the lamotrigine’s metabolism
When lenacapavir is used together with adenine, this leads to a reduction in the lenacapavir’s metabolism
When letermovir is used together with adenine, this leads to a reduction in the letermovir’s metabolism
When levothyroxine is used together with adenine, this leads to a reduction in the levothyroxine’s metabolism
When liothyronine is used together with adenine, this leads to a reduction in the liothyronine ’s metabolism
Actions and Spectrum:Â
Genetic Function: Adenine plays a crucial role in the genetic code as it pairs with thymine in DNA and uracil in RNA through hydrogen bonding. This base pairing is fundamental in maintaining the structural integrity and genetic information in nucleic acids.Â
Energy Transfer: The primary energy source in cells, adenosine triphosphate, is made up of the component adenine. ATP provides energy for various cellular processes by transferring phosphate groups.Â
Spectrum:Â
Biological Systems: It is found in the DNA and RNA of nearly all living organisms, making it a fundamental component of genetic material.Â
Cellular Metabolism: Adenine-containing molecules like ATP, NADH, and FADH2 participate in energy transfer and enzymatic reactions, impacting various metabolic pathways in cells.Â
Frequency not defined Â
Vomiting Â
Body odorÂ
HypotensionÂ
Excessive sweatingÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Allergy or hypersensitivity: Individuals with known hypersensitivity or allergic reactions to adenine or any related compounds should avoid its use.Â
Pregnancy and breastfeeding: Adequate studies may not exist regarding the safety of adenine during pregnancy or breastfeeding. Therefore, it’s advisable to avoid its use in these situations unless specifically recommended by a healthcare professional.Â
Certain medical conditions: Individuals with certain medical conditions, such as severe kidney disease or severe liver disease, may need to avoid adenine or use it with caution due to the potential for altered metabolism or excretion.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:
Adenine, an essential nucleobase, serves a pivotal function in the organization and structure of nucleic acids such as DNA and RNA.Â
Pharmacodynamics:Â Â
Role in Nucleic Acid Synthesis: Adenine is one of the four nucleobases found in DNA and RNA. It pairs with thymine in DNA and uracil in RNA through complementary base pairing. Drugs or compounds that affect nucleic acid synthesis may indirectly impact adenine utilization within these macromolecules.Â
Purine Metabolism Modulation: Adenine is part of the purine group, and drugs that influence purine metabolism may indirectly affect adenine levels. For instance, medications targeting enzymes involved in purine synthesis or degradation pathways may alter adenine concentrations within the body. Â
Pharmacokinetics:Â
AbsorptionÂ
 Adenine is absorbed in the gastrointestinal tract after ingestion. In the human body, adenine can be absorbed through active transport mechanisms in the small intestine.Â
DistributionÂ
Adenine is distributed throughout the body via the bloodstream. It’s an essential component of nucleic acid and is involved in various metabolic processes. It enters cells, where it can be utilized for the synthesis of nucleic acids or other cellular functions.Â
MetabolismÂ
Adenine undergoes various metabolic pathways in the body. It can be broken down into simpler molecules through degradation processes. In humans, adenine can be metabolized to uric acid via several enzymatic reactions, such as adenine deaminase and xanthine oxidase.Â
Excretion and EliminationÂ
The primary excretion route for adenine breakdown products, such as uric acid, is through the kidneys. The kidneys filter uric acid and eliminate it through urine. Some small amounts of adenine and its derivatives might also be excreted through feces.Â
Administration: Â
The route of administration is oral.Â
Several criteria, such as the specific condition being treated, the patient’s health situation, and the advice given by medical professionals or researchers, would determine the dosage and mode of administration
Patient information leafletÂ
Generic Name: adenineÂ
Why do we use adenine? Â
Adenine is a component of adenosine triphosphate; it is regarded as the cell’s energy currency. ATP stores and transfers energy within cells for various metabolic processes, such as muscle contractions, active transport, and biosynthesis.Â
Adenine is used extensively in biochemical research to study DNA replication, gene expression, molecular biology, and various cellular processes. Its role in nucleic acid structure and function makes it a crucial component in scientific investigations.Â
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