Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Pylera
Synonyms :
bismuth subcitrate potassium/metronidazole/tetracycline hydrochloride
Class :
Drugs for peptic ulcer & Mucosal protectors, antibiotic and antidiarrheal
Brand Name :
Pylera
Synonyms :
bismuth subcitrate potassium/metronidazole/tetracycline hydrochloride
Class :
Drugs for peptic ulcer & Mucosal protectors, antibiotic and antidiarrheal
Dosage Forms & Strengths
Capsule, Oral:
140 mg (bismuth subcitrate)
125 mg (metronidazole)
125 mg (tetracycline hydrochloride)
3
Capsules
4 times a day
after dinner at bedtime with omeprazole 20 mg twice a day for 10 to 14 days
Three capsules 4 times a day after dinner at bedtime with omeprazole
20 mg twice a day for 10 to 14 days
Refer to adult dosing
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
measles, mumps, rubella, and varicella vaccine, live (Rx)
may diminish the therapeutic effect
measles mumps and rubella vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
smallpox (vaccinia) vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
sodium picosulfate citric acid and magnesium oxide
it may reduce the therapeutic effect of sodium picosulfate
antibiotics may diminish the therapeutic effect of Bacillus clausii
antibiotics may diminish the therapeutic effect of Typhoid Vaccine
antibiotics may diminish the therapeutic effect of typhoid Vaccine
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
may diminish the absorption of iron preparations
may diminish the serum concentration when combined with tetracyclines
may diminish the serum concentration when combined with tetracyclines
may diminish the absorption of magnesium salts
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may decrease the therapeutic effect of Antacids
aluminum hydroxide/magnesium carbonateÂ
may decrease the serum concentration of antacids
it may diminish the therapeutic effect of cholera Vaccine
antibiotics decrease the efficacy of intravesical BCG
antibiotics decrease the efficacy of cholera vaccine
may diminish the absorption of magnesium salts
aluminum hydroxide/magnesium hydroxideÂ
may diminish the absorption of Antacids
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
antibiotics may reduce the therapeutic effect of immune checkpoint inhibitors
antibiotics may reduce the therapeutic effect of immune checkpoint inhibitors
antibiotics may reduce the therapeutic effect of immune checkpoint inhibitors
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the therapeutic effect
may reduce the therapeutic effect of penicillins
amoxicillin and clavulanate potassium
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may enhance the neuromuscular-blocking effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
They may diminish the absorption when combined with bile acid sequestrants
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
sodium picosulfate, citric acid, and magnesium oxide
may diminish the effect of each other when combined
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
antibiotics may reduce the therapeutic effect of bcg Vaccine
antibiotics decrease the efficacy of lactobacillus
may diminish the therapeutic effect of immune checkpoint inhibitors
may diminish the therapeutic effect of immune checkpoint inhibitors
may diminish the therapeutic effect of immune checkpoint inhibitors
may increase the hypoglycemic effect of sulfonylureas
may decrease the therapeutic effect of antibiotics
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may reduce the therapeutic effect of typhoid Vaccine
may decrease the rate of absorption
may decrease the rate of absorption
may decrease the rate of absorption
may decrease the rate of absorption
may diminish the absorption of magnesium salts
may diminish the absorption when combined with tetracyclines
It may enhance the risk of adverse effects when combined with Tetracyclines
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
antibiotics decrease the efficacy of Bacillus clausii
antibiotics decrease the efficacy of typhoid vaccine
Frequency defined:Â Â Â
<10%Â
Abnormal stools Â
1-10%:Â
HeadacheÂ
DizzinessÂ
Maculopapular rashÂ
Nausea Â
DiarrheaÂ
Abdominal painÂ
Dysgeusia Â
Dyspepsia Â
Constipation Â
Xerostomia Â
Vaginitis Â
Urine abnormality Â
Weakness   Â
<1%:Â
AnxietyÂ
Back painÂ
Chest painÂ
Duodenal ulcerÂ
EructationÂ
FlatulenceÂ
FatigueÂ
VomitingÂ
Skin rashÂ
Weight gainÂ
Pregnancy consideration: Combination is contraindicated for pregnant women. Metronidazole and tetracycline can cross the placenta and may cause harm to the fetus.Â
Lactation: Metronidazole and tetracycline both can be excreted in breast milk. Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: bismuth subcitrate potassium/metronidazole/tetracycline hydrochloride
Why do we use bismuth subcitrate potassium/metronidazole/tetracycline hydrochloride?Â
The combination of bismuth subcitrate potassium, metronidazole, and tetracycline hydrochloride is commonly used in a treatment regimen known as “concomitant therapy” for the eradication of Helicobacter pylori (H. pylori) bacteria. H. pylori is a bacterium that infects the stomach and can cause various gastrointestinal disorders, including gastritis, peptic ulcers, and even stomach cancer.
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