Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Onfi, Sympazan
Synonyms :
clobazam
Class :
Benzodiazepine anticonvulsants
Brand Name :
Onfi, Sympazan
Synonyms :
clobazam
Class :
Benzodiazepine anticonvulsants
Dosage Forms & StrengthsÂ
Tablet Â
5 mg Â
10 mg Â
20 mg Â
For initial dose:
Take dose of 5 mg orally daily in individuals with <30 kg
Take dose of 10 mg orally daily in individuals with >30 kg
Dose for day 7:
Take dose of 10 mg orally daily in individuals with <30 kg
Take dose of 20 mg orally daily in individuals with >30 kg
Dose for day 14:
Take dose of 20 mg orally daily in individuals with <30 kg
Take dose of 40 mg orally daily in individuals with >30 kg
Dosage Forms & StrengthsÂ
Tablet Â
5 mg Â
10 mg Â
20 mg Â
For 2 years or older:
For initial dose:
Take dose of 5 mg orally daily in individuals with <30 kg
Take dose of 10 mg orally daily in individuals with >30 kg
Dose for day 7:
Take dose of 10 mg orally daily in individuals with <30 kg
Take dose of 20 mg orally daily in individuals with >30 kg
Dose for day 14:
Take dose of 20 mg orally daily in individuals with <30 kg
Take dose of 40 mg orally daily in individuals with >30 kg
Refer to adult dosingÂ
may enhance the serum concentration when combined with fenfluramine
may increase the serum concentration when combined
when both drugs are combined, there may be a decreased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism  
the effect of clobazam is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the levels of serum concentrations of clobazam
may increase the levels of serum concentrations of clobazam
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
When dexrabeprazole and clobazam is used together, this leads to reduction in the dexrabeprazole’s metabolism
clobazam leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
clobazam leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
combining piperine with clobazam may lead to an increased serum concentration of clobazam
CYP2C19 inducers increase the concentration of clobazam in serum
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
mefloquine may diminish the therapeutic effect of antiseizure agents
it decreases the concentration of antiseizure agents in the serum
may enhance the serum concentration of CYP3A4 inhibitors
When clobazam is used together with lomitapide, this leads to an enhancement in lomitapide’s metabolism
clobazam might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
valproate products increase the CNS depressing effect of clobazam
they increase the toxicity of iobitridol
seizure lowering agents increase the toxic or adverse effects of iohexol
Actions and SpectrumÂ
Clobazam works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that inhibits nerve activity. Â
Clobazam has a calming effect on the central nervous system. Â
Frequency not defined Â
SleepinessÂ
FatigueÂ
Drug toleranceÂ
Speech disorderÂ
Decreased appetiteÂ
DepressionÂ
DizzinessÂ
Dryness in mouthÂ
IrritabilityÂ
AggressionÂ
HeadacheÂ
NauseaÂ
Sedation Â
RestlessnessÂ
Black Box WarningÂ
NoneÂ
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
Clobazam affects by binding to the GABA-A receptors, which are ligand-gated chloride channels. When GABA binds to its receptor, chloride channels open, leading to an influx of chloride ions into the neuron. Â
PharmacodynamicsÂ
The enhanced activity of GABA leads to hyperpolarization of the neuronal membrane. This hyperpolarization makes it more difficult for the neuron to reach its threshold for firing, reducing the chances of excessive neuronal activity and seizures.Â
PharmacokineticsÂ
Absorption  Â
Clobazam is well-absorbed from the gastrointestinal tract after oral administration. Â
DistributionÂ
Clobazam distribute throughout various tissues in the body.Â
MetabolismÂ
Clobazam undergoes hepatic metabolism.Â
Elimination and excretionÂ
Clobazam is excreted in urine and feces.Â
AdministrationÂ
Clobazam is administered orally in the form of tablets or suspension.Â
Patient information leafletÂ
Generic Name: clobazamÂ
Why do we use clobazam?Â
Clobazam is indicated as an adjunctive treatment for seizures associated with various forms of epilepsy.  Â
Clobazam is commonly used in the treatment of seizures associated with Lennox-Gastaut syndrome (LGS).Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
