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Brand Name :
Adifax/Redux
Synonyms :
dexfenfluramine, dextrofenfluramine
Class :
Antiobesity Preparations
Brand Name :
Adifax/Redux
Synonyms :
dexfenfluramine, dextrofenfluramine
Class :
Antiobesity Preparations
Dosage Forms & Strengths
Capsule
15mg
30mg
Safety and efficacy not established
Refer adult dosing
may have an increased Effect of CNS depressant when combined with serotonergic anorectic drugs
may have an increased Effect of CNS depressant when combined with serotonergic anorectic drugs
may have an increased Effect of CNS depressant when combined with serotonergic anorectic drugs
may enhance the serotonergic effect of opioid agonists
May have an increased serotonergic effect when combined with Serotonergic Agents
it increases the effect of serotonergic agents
may enhance the serotonergic effect of serotonergic Agents
may enhance the serotonergic effect of serotonergic Agents
may enhance the serotonergic effect of serotonergic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
Serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
serotonergic agents may enhance the adverse/toxic effect of anti-psychotic agents
serotonergic agents may enhance the adverse/toxic effect of anti-psychotic agents
may enhance the serotonergic effect of serotonergic agents
may enhance the serotonergic effect of serotonergic agents
may enhance the serotonergic effect of serotonergic agents
may enhance the serotonergic effect of serotonergic agents
may enhance the serotonergic effect of serotonergic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
it may diminish the metabolism when combined with aripiprazole lauroxil
when bromazepam and dexfenfluramine are used together, there is a potential reduction in the bromazepam's metabolism
When dexfenfluramine is used together with somatotropin, this leads to a rise in dexfenfluramine metabolism
When encainide is used together with dexfenfluramine, this leads to a reduction in the encainide’s metabolism
may have an increasingly adverse effect when combined with antipsychotic agents
may have an increasingly adverse effect when combined with antipsychotic agents
may have an increasingly adverse effect when combined with antipsychotic agents
may have an increasingly adverse effect when combined with Antipsychotic Agents
may have an increasingly adverse effect when combined with Antipsychotic Agents
may have an increasingly adverse effect when combined with Antipsychotic Agents
may have an increasingly adverse effect when combined with Antipsychotic Agents
may have an increasingly adverse effect when combined with Antipsychotic Agents
When indisulam is used together with dexfenfluramine, this leads to a reduction in dexfenfluramine metabolism
When both drugs are combined, there may be an increased risk of bleeding
antiemetics may enhance the serotonergic effect of serotonergic Agents
antiemetics may enhance the serotonergic effect of serotonergic Agents
antiemetics may enhance the serotonergic effect of serotonergic Agents
antiemetics may enhance the serotonergic effect of serotonergic Agents
ergot Derivatives may enhance the serotonergic effect of serotonergic Agents
ergot Derivatives may enhance the serotonergic effect of serotonergic Agents
ergot Derivatives may enhance the serotonergic effect of serotonergic Agents
ergot Derivatives may enhance the serotonergic effect of serotonergic Agents
ergot Derivatives may enhance the serotonergic effect of serotonergic Agents
it increases the toxicity of serotonergic agents
alosetron increases the effect of serotonergic agents
may enhance the effect of serotonergic agents
may enhance the effect of serotonergic agents
may enhance the effect of serotonergic agents
may enhance the effect of serotonergic agents
may increase the vasoconstricting effect of ergot derivatives
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
May have an increased serotonergic effect when combined with Serotonergic Agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
it increases the effect of serotonergic agents
it increases the effect of serotonergic agents
it increases the effect of serotonergic agents
it increases the effect of serotonergic agents
it increases the effect of serotonergic agents
may enhance the effect of Serotonergic Agents
may enhance the effect of Serotonergic Agents
may enhance the effect of Serotonergic Agents
may enhance the effect of Serotonergic Agents
may enhance the effect of Serotonergic Agents
it increases the toxicity of serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
mazindol increases the toxicity of lithium in the serum anorectics
it increases the effect of serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
may have an increased serotonergic effect when combined with serotonergic agents
Actions and Spectrum:
Dexfenfluramine is largely a serotonin-releasing and reuptake inhibitor. It boosts the production of serotonin in brain while suppressing its reuptake. Dexfenfluramine was created primarily to treat obesity. Its spectrum of action was designed to induce weight loss in obese people by suppressing hunger and promoting fullness.
Frequency not defined
Asthenia
Chills
Infection
Back pain
Headache
Abdominal pain
Accidental injury
Flu syndrome
Fever
Black box warning:
None
Contraindications/caution:
Contraindications:
Cardiovascular Disease
Valvular Heart Disease
Stroke
Pulmonary Hypertension
Pregnancy Warnings:
Pregnancy consideration: It is contraindicated in pregnant women due to potential risks to the fetus or infant.
Lactation: It is contraindicated in breastfeeding women due to potential risks to the infant.
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Dexfenfluramine is a medication used to manage obesity. It works by increasing serotonin levels in the brain.
Pharmacodynamics:
Serotonin is a chemical that can suppress appetite and make you feel full.
Pharmacokinetics:
Absorption
It gets absorbed into your bloodstream from your gastrointestinal tract.
Distribution
It gets distributed to various tissues, including the brain.
Metabolism
In the liver, the drug undergoes extensive processing by enzymes.
Elimination and Excretion
The drug and its byproducts are then excreted through your urine and bile, with a half-life of 4-5 hours.
Administration:
Oral administration
It is administered orally
Patient information leaflet
Generic Name: dexfenfluramine
Why do we use dexfenfluramine?
Dexfenfluramine helps reduce calorie intake and treat both obesity and diabetes. It does this by stimulating serotonin receptors, which leads to decreased appetite and increased feelings of fullness.
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