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Brand Name :
DEXPURE, KYRAB
Synonyms :
dexrabeprazole
Class :
Antacids
Brand Name :
DEXPURE, KYRAB
Synonyms :
dexrabeprazole
Class :
Antacids
Dosage forms and strengths
KYRAB tablet 10 mg
Gastroesophageal Reflux Disease (GERD)Â
Take 10 mg one time a day for the duration of four to eight weeks, which depends upon the condition and body response
The recommended maintenance dose is 5 to 10 mg one time a day
Take 10 mg one time a day for the duration of four to eight weeks, which depends upon the condition and body response
The recommended maintenance dose is 5 to 10 mg one time a day
Take 10 mg one time a day for the duration of four to eight weeks, which depends upon the condition and body response
The recommended maintenance dose is 5 to 10 mg one time a day
Not indicated
Refer adult dosing
When dexrabeprazole and albendazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and alpelisib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and amiodarone is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and amitriptyline is used together, this leads to reduction in the dexrabeprazole’s metabolism
When amlodipine and dexrabeprazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and amprenavir is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and apixaban is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and armodafinil is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and artemether is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and asciminib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and axitinib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and benzocaine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and bortezomib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and buprenorphine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and cannabidiol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and carbamazepine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and carisoprodol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and chloramphenicol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and cimetidine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and citalopram is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and clevidipine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and clobazam is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and clomipramine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and clopidogrel is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and clozapine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and cyclophosphamide is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and dexlansoprazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and diazepam is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and dosulepin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and doxazosin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and doxepin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and dronabinol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and efavirenz is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and enasidenib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and escitalopram is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and esketamine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and esomeprazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and estradiol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and ethambutol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and etoricoxib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and felbamate is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and fenofibrate is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and fexinidazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and fluconazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and fluoxetine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and fluvoxamine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and formoterol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and fosphenytoin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and imatinib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and imipramine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and isoniazid is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and labetalol is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and lacosamide is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and lansoprazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and letrozole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and lonafarnib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and losartan is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and mephenytoin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and methadone is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and methimazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and methsuximide is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and methylene blue is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and miconazole is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and moclobemide is used together, this leads to reduction in the dexrabeprazole’s metabolism
When dexrabeprazole and modafinil is used together, this leads to reduction in the dexrabeprazole’s metabolism
Actions and Spectrum:
Action:
Like other PPIs, the primary action of dexrabeprazole would likely be to inhibit the proton pump in the stomach lining. This inhibition reduces gastric acid secretion into the stomach, effectively decreasing the acidity of gastric contents.
Spectrum:
Gastroesophageal Reflux Disease: dexrabeprazole would likely be used to manage and alleviate the symptoms of GERD, such as heartburn, regurgitation, and chest pain, by reducing the acidity of stomach contents.
Peptic Ulcers: It might treat peptic ulcers (both gastric and duodenal ulcers) to promote ulcer healing and prevent their recurrence by reducing stomach acid secretion.
Pharyngitis
Flatulence
Asthenia
Abdominal pain
Rhinitis
Diarrhoea
Headache
Nausea
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: Individuals with a known hypersensitivity or allergy to dexrabeprazole or its ingredients should not use this medication.
Liver Impairment: People with severe liver impairment should use dexrabeprazole cautiously, as the medication may be metabolized more slowly in such cases, leading to increased drug levels in the bloodstream.
Pregnancy and Breastfeeding: The safety of dexrabeprazole during pregnancy and breastfeeding has not been well-established. It is crucial to seek advice from a healthcare professional before using this medication if you are pregnant or nursing.
Pediatric Use: dexrabeprazole’s safety and effectiveness have not been adequately studied in children under 12. It is typically not recommended for use in this age group.
Multiple Drug Interactions: dexrabeprazole can interact with other medications, potentially affecting their absorption or efficacy. You must disclose all your medications, supplements, and herbal products to your healthcare provider to prevent possible drug interactions.
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation:Â Excreted into human milk is unknown
Pregnancy Categories:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacology:
dexrabeprazole belongs to the class of proton pump inhibitors.
Pharmacodynamics:
dexrabeprazole exerts its pharmacological effects primarily by inhibiting the gastric H+/K+-ATPase proton pump located on the surface of parietal cells in the stomach.
Pharmacokinetics:
Absorption
dexrabeprazole exhibits high oral bioavailability, and absorption primarily occurs in the small intestine. It is rapidly absorbed after oral administration, reaching peak plasma concentrations within 1-2 hours.
Distribution
dexrabeprazole has a moderate volume of distribution, indicating its distribution throughout body tissues. It does not significantly bind to plasma proteins.
Metabolism
Metabolism of dexrabeprazole primarily occurs in the liver, where it undergoes hepatic biotransformation by the cytochrome P450 enzymes, primarily CYP2C19. These metabolic processes generate inactive metabolites.
Excretion and Elimination
The elimination half-life of dexrabeprazole is approximately 1-2 hours, with minimal faecal excretion, the drug and its metabolites are mainly eliminated in the urine.
Administration:Â
dexrabeprazole is likely administered orally, in the form of tablets or capsules.
Swallow the medication whole with a glass of water.
Do not crush or chew unless instructed otherwise.
Patient information leaflet
Generic Name: dexrabeprazole
Why do we use dexrabeprazole?
dexrabeprazole is often prescribed to manage GERD which causing heartburn, regurgitation, and discomfort. It helps relieve symptoms and promotes healing of the esophageal lining.
dexrabeprazole is used in the treatment of peptic ulcers, which can develop in the upper portion of the small intestine (duodenal ulcers) or the stomach (gastric ulcers). It helps by reducing stomach acid production, allowing the ulcer to heal.
dexrabeprazole is used to manage this zollinger-ellison syndrome by reducing acid secretion and alleviating associated symptoms.
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