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November 5, 2025
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Brand Name :
Docivyx
(United States) [Available]Synonyms :
Docetaxel
Class :
Anticancer & taxanes
Brand Name :
Docivyx
(United States) [Available]Synonyms :
Docetaxel
Class :
Anticancer & taxanes
AdultÂ
Injectable solutionÂ
10mg/mlÂ
20mg/mlÂ
Alcohol-free solution for injectionÂ
20mg/mlÂ
80mg/4mlÂ
160mg/8mlÂ
Safety and efficacy not determined.Â
Refer as per adult doseÂ
may increase excessive immunosuppressive effects and risk of infection
adenovirus types and live oral
may reduce the therapeutic effects of the vaccine
increase immunosuppressive effects and risk of infection
may increase the serum levels and effects of docetaxel
may raise the risk of neutropenia due to myelosuppression
may increase myelosuppression and immunosuppression
may raise the risk of pancytopenia and agranulocytosis due to myelosuppression
may increase bone marrow suppression
may increase the serum concentration of CYP3A4 substrates
increases the serum concentration of BCRP/ABCG2 substrates
The interaction may enhance the myelosuppressive effects
May increase serum level and toxic effects of docetaxel by affecting MDR1/PG-P efflux transporter
Docetaxel may increase the serum level of atogepant by affecting the enzyme CYP3A4
May increase serum level and toxic effects of docetaxel by affecting MDR1/PG-P efflux transporter
Docetaxel may increase the serum level of avapritinib by affecting the enzyme CYP3A4
Docetaxel may increase the serum level of axitinib by affecting the enzyme CYP3A4
May increase excessive immunosuppressant activity docet
May decrease the serum level of docetaxel by affecting the enzyme CYP3A4
May increase serum level and toxic effects of docetaxel by affecting MDR1/PG-P efflux transporter
May increase serum level and toxic effects of docetaxel by affecting MDR1/PG-P efflux transporter
May decrease the serum level of docetaxel by affecting the enzyme CYP3A4
May decrease the serum level of docetaxel by affecting the enzyme CYP3A4
may diminish the therapeutic effects of the cholera vaccine
cimetidine may enhance the level and effect of docetaxel by affecting CYP3A4
may enhance the level and effect of docetaxel by affecting CYP3A4
may enhance serum level or toxic effect by affecting MDR1/PG-P efflux transporter
may increase serum level of docetaxel
may enhance serum level and toxicity of docetaxel
may enhance the serum level of docetaxel
decrease the serum level of docetaxel by affecting CYP3A4
may diminish the therapeutic effects of the dengue vaccine
may enhance excessive immunosuppressant effects
may enhance the serum levels and adverse effects of docetaxel
may enhance serum levels of docetaxel by affecting the MDR1/PG-P efflux transporter
may enhance serum concentration and therapeutic effects of docetaxel
may reduce therapeutic effects of docetaxel
may reduce therapeutic effects of docetaxel by inducing hepatic metabolism enzyme CYP3A4
may enhance serum levels of docetaxel by inducing MDR1/PG-P efflux transporter
may enhance the metabolism of both drugs and reduce the plasma concentration
may increase serum levels and the effect of docetaxel
may reduce levels of ethotoin by decreasing GI absorption
may enhance the serum level of docetaxel
may enhance the serum level and effect of docetaxel
docetaxel may enhance serum level and therapeutic effects of finerenone
may increase the risk of severe infection due to excessive immunosuppression
may increase excessive immunosuppressive effects
may enhance the risk of serious infection due to combined immunosuppressive effects
may increase the risk of bone marrow suppression
may raise the risk of myelosuppression and immunosuppression
may reduce the effects of docetaxel by affecting the MDR1/PG-P efflux transporter
may reduce serum levels of docetaxel by affecting MDR1/PG-P efflux transporter
may increase the serum concentration of docetaxel
may reduce intracellular concentration by affecting the MDR1/Pg-P efflux transporter
may increase the serum concentration of docetaxel
increases serum levels by affecting hepatic metabolism of docetaxel
interaction increases the serum concentration of docetaxel
may increase excessive immunosuppressive effects
may raise the risk of neutropenia and serious infection by increasing immunosuppressant
decrease level of docetaxel
may increase serum levels of docetaxel
may increase serum levels of docetaxel
may increase serum levels of docetaxel
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may increase the levels of serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Substrates
it may enhance the metabolism when combined with oxcarbazepine
When alprazolam and docetaxel is used together, this leads to reduction in the alprazolam’s metabolism
When docetaxel is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When docetaxel is used together with oleandomycin, this leads to enhanced concentration serum of docetaxel
When docetaxel is used together with ridaforolimus, this leads to enhanced concentration serum of docetaxel
the effect of docetaxel is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
an increase in the metabolism of docetaxel can be observed when administered with aminoglutethimide
Action:Â
Docetaxel, a taxane, is a second-gen chemo drug. It binds beta-tubulin to halt cell cycling at G2/M by preventing proper microtubule assembly. Also, it reduces BCL2 gene expression, aiding tumor cell apoptosis.Â
Frequency defined: Â
>50% Â
Alopecia (56%) Â
Anemia (65%) Â
Leukopenia (84%) Â
Neutropenia (84%) Â
Asthenia (53%) Â
10-50% Â
Infections Â
Fluid retention Â
Hypersensitivity Â
Diarrhea Â
Nausea Â
Sensory neuropathy Â
Myalgia Â
1-10% Â
Arthralgia Â
Thrombocytopenia Â
Blackbox warningÂ
None Â
Contraindication/Caution: Â
Contraindication: Â
Caution: Â
Pregnancy/Lactation:Â
Pregnancy consideration: docetaxel is assigned under pregnancy category C. It should be used with caution for pregnant women. Â
Lactation: No data available for excretion in breast milk, it should be avoided due to potential side effects Â
Pregnancy category: Â
Pharmacology: Â
Docetaxel, an antineoplastic agent, is indicated to treat non-resectable and metastatic tumor types. It is a newer taxane agent. Â
Pharmacodynamics:Â
Docetaxel disrupts cell activity by binding to microtubules, halting cell division and stabilizing them, ultimately leading to cell cycle arrest and death.Â
Pharmacokinetics:Â
Absorption Â
Docetaxel’s area under the curve is 5.93 µg.h/ml, and its Cmax is 2.41 µg/ml. Â
Distribution 
Proteins bind to 94-97% of docetaxel. Its distribution volume is 80-90 L/m².Â
Metabolism Â
The liver is where docetaxel is metabolized. According to in vitro research, it is metabolized by the isoenzyme CYP3A4. Â
Excretion and eliminationÂ
Docetaxel is excreted in feces in 75% of cases and urine in 6% of cases. Â
Half-life: Â
Termination half-life is 116 hoursÂ
Administer through intravenous route in solution form and infuse over 1 hour.Â
Taxane derivatives should be given prior to platinum derivatives when given as consecutive infusions to minimize myelosuppression and improve efficacy.Â
Generic Name: docetaxel   Â
Pronounced: do-ce-tax-el Â
Why do we use Docetaxel?Â
Docetaxel is used to various types of treat cancer including lung, breast, prostate, and head/neck cancer.Â
Docetaxel is used to treat locally progressed or metastatic breast cancer following chemotherapy failure. Â
It can also be used in conjunction with doxorubicin and cyclophosphamide as an adjuvant treatment for operable node-positive breast cancer.
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