Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Silenor
Synonyms :
doxepin
Class :
Antidepressants and antianxiety drugs; Norepinephrine Reuptake Inhibitors
Brand Name :
Silenor
Synonyms :
doxepin
Class :
Antidepressants and antianxiety drugs; Norepinephrine Reuptake Inhibitors
Dosage forms & Strengths
Tablet
3 mg
6 mg
Capsule
10 mg
25 mg
50 mg
75 mg
100 mg
150 mg
Oral concentrate
10 mg/ml
25
mg
daily; titrate gradually
5 - 7
days
the dose range is 25-300 mg orally daily,
do not exceed 150 mg daily
3 - 6
mg
Orally 
30 minutes before going to bed
Do not exceed 6 mg daily
Not recommended for pediatricsÂ
Refer adult dosing
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may have an increased QTc-prolonging effect when combined with doxepin-containing products
may have an increased QTc-prolonging effect when combined with doxepin-containing products
may have an increased QTc-prolonging effect when combined with doxepin-containing products
may have an increased QTc-prolonging effect when combined with doxepin-containing products
may have an increased QTc-prolonging effect when combined with doxepin-containing products
it increases the toxicity of norepinephrine reuptake inhibitors
it increases the effect of serotonergic agents
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
anticholinergic agents decrease the efficacy of levosulpride
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
anticholinergic agents increase the ulcer-producing effect of potassium citrate
CNS depressants increase the CNS suppression effect of thalidomide
it increases the effect of Norepinephrine Reuptake Inhibitors
It may enhance QTc interval when combined with perphenazine
QTc interval increases on taking doxepin and lenvatinib together. Avoid or take an alternate drug.
may increase the QT-prolonging effect
when both drugs are combined, there may be an increased QTc interval 
glycopyrrolate inhaled and formoterolÂ
may increase the QTc interval when combined
CNS depressants increase the CNS depressing effect of brexanolone
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
it increases the effect of CNS depressants
it increases the toxicity of serotonergic agents
it increases the effect of CNS depressants
anticholinergic agents increase the toxicity of topiramate
It may reduce the effects when combined with pleurisy root by unspecified interactions mechanism
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
doxepin and loperamide are both known to elevate the QTc interval
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
Combining doxepin with pranlukast may cause a reduction in the doxepin’s metabolism
The potential for increased CNS depression risk or seriousness occurs when doxepin is used together with pinazepam
when ajmaline is used together with doxepin, the risk or seriousness of QTc prolongation is enhanced
The potential for increased CNS depression risk or seriousness occurs when doxepin is used together with pipecuronium
When doxepin is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When doxepin is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when doxepin is used together with fencamfamin
When doxepin is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dexrabeprazole and doxepin is used together, this leads to reduction in the dexrabeprazole’s metabolism
When doxepin is used together with somatotropin, this leads to a rise in doxepin metabolism
doxepin: they may enhance the serum concentration of CYP2D6 Inhibitors
doxepin: they may enhance the serum concentration of CYP2D6 Inhibitors
doxepin: they may enhance the serum concentration of CYP2D6 Inhibitors
doxepin: they may enhance the serum concentration of CYP2D6 Inhibitors
doxepin: they may enhance the serum concentration of CYP2D6 Inhibitors
When doxepin is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When doxepin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When doxepin is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When bufexamac is used together with doxepin, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When doxepin is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When doxepin is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
may decrease the anticholinergic effect
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
anticholinergic agents increase the effect of constipation of clozapine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of norepinephrine reuptake inhibitors
anticholinergic agents decrease the efficacy of secretin
CNS depressants increase the effect of zolpidem
relugolix/​estradiol/​norethindroneÂ
may increase the effect of each other by an unknown mechanism
Frequency undefined:Â
SedationÂ
Fatigue, Â
WeaknessÂ
LethargyÂ
Dry mouthÂ
Blurred visionÂ
HeadacheÂ
AgitationÂ
InsomniaÂ
AnxietyÂ
NauseaÂ
VomitingÂ
SweatingÂ
ConfusionÂ
Extrapyramidal symptoms Â
Orthostatic hypotension Â
ECG changesÂ
TachycardiaÂ
Increased LFTsÂ
TinnitusÂ
Sexual dysfunctionÂ
RashÂ
SeizureÂ
AgranulocytosisÂ
ThrombocytopeniaÂ
EosinophiliaÂ
LeukopeniaÂ
SIADHÂ
Doxepin is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.Â
Pregnancy consideration:Â Â
Do not take doxepin during pregnancy.Â
Breastfeeding warnings:Â Â
Use the drug cautiously during lactation.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name:Â doxepinÂ
Pronounced: doks-e-pinÂ
Why do we use doxepin?Â
doxepin is a tricyclic antidepressant (TCA) that is used for various medical conditions. Here are some common uses of doxepin:
doxepin is primarily used for the treatment of depression. It works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which helps to alleviate symptoms of depression.
doxepin may also be used to treat anxiety disorders such as generalized anxiety disorder (GAD) and panic disorder. It helps to reduce anxiety symptoms such as nervousness, worry, and fear by affecting the levels of certain neurotransmitters in the brain.
It is also used to treat insomnia, particularly in low doses. It can help improve sleep quality and duration by promoting drowsiness and reducing the time it takes to fall asleep.
It can be used as part of a treatment plan for chronic pain conditions such as neuropathic pain, fibromyalgia, and chronic headaches. It can help alleviate pain by affecting the levels of certain neurotransmitters in the brain that are involved in pain perception.
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