Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Disomnilan, Flunepan, Flunita, Flunitrazepam CF
Synonyms :
flunitrazepam
Class :
Benzodiazepine derivative, Hypnotic agent
Brand Name :
Disomnilan, Flunepan, Flunita, Flunitrazepam CF
Synonyms :
flunitrazepam
Class :
Benzodiazepine derivative, Hypnotic agent
Dosage Forms & StrengthsÂ
Tablet, film coatedÂ
Oral: 1 mgÂ
(off-label):
1 to 2 mg given orally before the bedtime
Safety and efficacy were not establishedÂ
Refer to the adult dosing regimenÂ
may have an increased CNS depressant effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
CNS depressants may have an increased CNS depressive effect when combined with flunitrazepam
CNS depressants may have an increased CNS depressive effect when combined with flunitrazepam
CNS depressants may have an increased CNS depressive effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
may have an increased CNS depressant effect when combined with flunitrazepam
flunitrazepam: they may increase the CNS depressant effect of CNS Depressants
flunitrazepam: they may increase the CNS depressant effect of CNS Depressants
flunitrazepam: they may increase the CNS depressant effect of CNS Depressants
may have an increased effect of CNS depression when combined with Acetazolamide
may have an increased effect of CNS depression when combined with Acetophenazine
may have an increased effect of CNS depression when combined with Agomelatine
may have an increasingly adverse effects when combined with Alfentanil
may have an increased effect of CNS depression when combined with Alimemazine
may have an increased effect of CNS depression when combined with Almotriptan
may have an increased effect of CNS depression when combined with Alosetron
may have an increased effect of CNS depression when combined with Amobarbital
may enhance the risk of CNS depression when combined with each other
may increase the CNS depressant effect
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effects of CNS depressants
may increase the CNS depressants effects of CNS depressants
acrivastine and pseudoephedrineÂ
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
promethazine/dextromethorphanÂ
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
buprenorphine,long-acting injectionÂ
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may have an increased effect of CNS depression when combined with Alprazolam
may have an increased effect of CNS depression when combined with Amisulpride
may have an increased effect of CNS depression when combined with Amitriptyline
may have an increased effect of CNS depression when combined with Amoxapine
may increase the CNS depressant effect of CNS depressants
may have an increased effect of CNS depression when combined with Apomorphine
may have an increased effect of orthostatic hypotension when combined with Aripiprazole
may have an increased effect of CNS depression when combined with Aripiprazole lauroxil
may have an increased effect of CNS depression when combined with Articaine
may have an increased effect of CNS depression when combined with Asenapine
may have an increased effect of CNS depression when combined with Atracurium besylate
The potential for increased CNS depression risk or seriousness occurs when flunitrazepam is used together with pipecuronium
flunitrazepam: they may enhance the serum concentration of CYP2D6 Inhibitors
flunitrazepam: they may enhance the serum concentration of CYP2D6 Inhibitors
flunitrazepam: they may enhance the serum concentration of CYP2D6 Inhibitors
flunitrazepam: they may enhance the serum concentration of CYP2D6 Inhibitors
flunitrazepam: they may enhance the serum concentration of CYP2D6 Inhibitors
may enhance the risk of CNS depression when combined with each other
CNS depressants increase the effect of flunitrazepam
Actions and spectrum:Â
flunitrazepam is a benzodiazepine medication with sedative, hypnotic, anxiolytic, muscle relaxant, and anticonvulsant properties. It acts on the central nervous system by enhancing the inhibitory effects of GABA, a neurotransmitter that reduces brain activity and induces relaxation. As a result of these actions, flunitrazepam produces calming and sleep-inducing effects.Â
The spectrum of flunitrazepam’s effects includes:Â
Frequency not definedÂ
SedationÂ
HeadacheÂ
Visual disturbancesÂ
insomniaÂ
DizzinessÂ
nauseaÂ
vomitingÂ
depressionÂ
AmnesiaÂ
Black Box Warning:Â
flunitrazepam carries a black box warning due to its high potential for abuse, addiction, and adverse effects. It can cause severe respiratory depression, especially when combined with alcohol.
Additionally, abrupts the discontinuation may lead to withdrawal symptoms, making it crucial to use this medication under strict medical supervision and for short durations.Â
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Comorbidities:Â
Pregnancy consideration: pregnancy category: not assignedÂ
Lactation: excreted into human milk: yes Â
Pregnancy category:Â
Pharmacology:Â
flunitrazepam is a benzodiazepine with sedative, hypnotic, anxiolytic, muscle relaxant, and anticonvulsant properties. It acts on the central nervous system by enhancing the inhibitory effects of GABA, an inhibitory neurotransmitter, leading to increased GABA-mediated synaptic inhibition.
This results in the suppression of neuronal activity, leading to sedation and relaxation. flunitrazepam’s pharmacological effects make it effective in treating insomnia and anxiety disorders. However, it also carries the potential for misuse, dependence, and tolerance development, necessitating caution and limited use for short-term treatment. Â
Pharmacodynamics:Â
Pharmacokinetics:Â
AbsorptionÂ
flunitrazepam is administered orally as a tablet or intravenously. It is rapidly and well absorbed from the GIT after oral administration, with peak plasma concentrations reached within 1 to 2 hours.Â
DistributionÂ
flunitrazepam is highly lipophilic, allowing it to readily crosses blood-brain barrier and distribute throughout the body’s tissues.Â
MetabolismÂ
flunitrazepam undergoes extensive hepatic metabolism in the liver. It is primarily metabolized by cytochrome P450 enzyme system, with CYP3A4 and CYP2C19 being the main enzymes involved.Â
Elimination and excretionÂ
The elimination half-life of flunitrazepam is around 18 to 26 hours in healthy individuals. It undergoes hepatic metabolism and is excreted in the urine as metabolites. Only a small percentage of the drug is excreted unchanged in the urine.Â
Administration:Â
Patient information leafletÂ
Generic Name: flunitrazepamÂ
Pronounced: floo-ni-TRAZ-e-pam Â
Why do we use flunitrazepam?Â
flunitrazepam is a benzodiazepine medication primarily used for its sedative-hypnotic properties.Â
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