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Brand Name :
N/A
Synonyms :
insulin beef
Class :
Blood Glucose glucose-lowering agents
Brand Name :
N/A
Synonyms :
insulin beef
Class :
Blood Glucose glucose-lowering agents
Dosage Forms & Strengths
More than 80 units of insulin beef is required in a day. The 1980s observed a significant decrease in the usage of animal insulin as human insulin became available through recombinant DNA technology.
In the US, commercial supplies of beef, pork, and pork insulin are no longer available. If a patient cannot receive human insulin treatment, the US FDA may permit the personal importation of cattle or pork insulin from another nation.
More than 80 units of insulin beef is required in a day.
The 1980s observed a significant decrease in the usage of animal insulin as human insulin became available through recombinant DNA technology.
In the US, commercial supplies of beef, pork, and pork insulin are no longer available. If a patient cannot receive human insulin treatment, the US FDA may permit the personal importation of cattle or pork insulin from another nation.
Dosage Forms & Strengths
Discontinued in Canada and USA
Refer adult dosing
may increase the hypoglycemic effect of Sodium-Glucose Cotransporter 2 Inhibitors
may increase the Glucose-lowering effect of SGLT2 Inhibitors
Dipeptidyl Peptidase-IV Inhibitors: they may increase the hypoglycemic effect of insulins
Dipeptidyl Peptidase-IV Inhibitors: they may increase the hypoglycemic effect of insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulin
may have an increased hypoglycemic effect when combined with insulin
may have an increased hypoglycemic effect when combined with insulin
may decrease the therapeutic effect of corticosteroids
may increase the toxic effects
may increase the toxic effects
may increase the toxic effects
may increase the toxic effects
may increase the toxic effects
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
may increase the effect of insulins
may increase the effect of insulins
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycaemic effect
may increase the hypoglycemic effect of quinolones
may diminish the therapeutic effect of antidiabetic agents
may diminish the therapeutic effect of antidiabetic agents
may diminish the therapeutic effect of antidiabetic agents
may diminish the therapeutic effect of antidiabetic agents
choline magnesium trisalicylate
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect of beta blockers
may increase the effect of insulins
may increase the effect of insulins
may increase the effect of insulins
may increase the effect of insulins
may increase the effect of insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of insulins
dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of insulins
Actions and Spectrum:
insulin beef, also known as bovine insulin, is a type of insulin derived from cattle. It is used in some medical contexts, especially in the treatment of diabetes. The mechanism of action and spectrum of activity of insulin beef are similar to those of human insulin.
Insulin is a hormone that plays a crucial role in glucose metabolism. The primary mechanism of action of insulin, including insulin beef, involves its interaction with insulin receptors on cell surfaces. The process can be summarized as follows:
Spectrum of Activity:
The spectrum of activity of insulin beef is broad, as it serves as a replacement therapy for individuals with diabetes who lack or have insufficient endogenous insulin. Insulin beef can be used for:
Type 1 Diabetes: Individuals with type 1 diabetes have little to no insulin production. Insulin beef is often prescribed to replace the missing insulin and control blood glucose levels.
Type 2 Diabetes: In some cases of type 2 diabetes, where there is insufficient insulin production or the body’s cells do not respond effectively to insulin, supplemental insulin may be required.
Frequency not defined
Nausea
Tiredness
Perspiration
Heart palpitations
Confusion
Hunger
Headache
Black box warning:
None
Pharmacology:
insulin beef, also known as bovine insulin, has pharmacological properties like human insulin. Insulin is a peptide hormone that plays a crucial role in the regulation of glucose metabolism.
Like human insulin, insulin beef acts by binding to insulin receptors on the surface of target cells, including muscle, adipose tissue, and the liver. Binding activates the insulin receptor, leading to intracellular signaling events that facilitate the cellular uptake of glucose, promote glycogen synthesis, and inhibit gluconeogenesis.
Pharmacokinetics:
Absorption
insulin beef is typically administered subcutaneously (under the skin) to ensure absorption into the bloodstream. The rate of absorption can be influenced by factors such as the injection site, blood flow to the injection site, and the specific formulation.
Distribution
Once absorbed into the bloodstream, insulin beef is distributed to various tissues in the body. The distribution is influenced by factors such as blood flow, capillary permeability, and the presence of insulin receptors on target cells.
Metabolism
insulin, including insulin beef, undergoes metabolism primarily in the liver and, to some extent, in peripheral tissues. The metabolism of insulin involves enzymatic processes that break down the peptide structure into smaller fragments.
Elimination and Excretion
The metabolites of insulin, including insulin beef, are excreted by the kidneys. The elimination half-life of insulin in the bloodstream is relatively short, requiring frequent administration to maintain therapeutic levels.
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
insulin beef, also known as bovine insulin, has pharmacological properties like human insulin. Insulin is a peptide hormone that plays a crucial role in the regulation of glucose metabolism.
Like human insulin, insulin beef acts by binding to insulin receptors on the surface of target cells, including muscle, adipose tissue, and the liver. Binding activates the insulin receptor, leading to intracellular signaling events that facilitate the cellular uptake of glucose, promote glycogen synthesis, and inhibit gluconeogenesis.
Pharmacokinetics:
Absorption
insulin beef is typically administered subcutaneously (under the skin) to ensure absorption into the bloodstream. The rate of absorption can be influenced by factors such as the injection site, blood flow to the injection site, and the specific formulation.
Distribution
Once absorbed into the bloodstream, insulin beef is distributed to various tissues in the body. The distribution is influenced by factors such as blood flow, capillary permeability, and the presence of insulin receptors on target cells.
Metabolism
insulin, including insulin beef, undergoes metabolism primarily in the liver and, to some extent, in peripheral tissues. The metabolism of insulin involves enzymatic processes that break down the peptide structure into smaller fragments.
Elimination and Excretion
The metabolites of insulin, including insulin beef, are excreted by the kidneys. The elimination half-life of insulin in the bloodstream is relatively short, requiring frequent administration to maintain therapeutic levels.
Administration:
insulin beef is typically administered subcutaneously, meaning it is injected into the fatty tissue just beneath the skin. This route allows for a slower and more consistent absorption of insulin into the bloodstream.
Patient information leaflet
Generic Name: insulin beef
Why do we use insulin beef?
insulin beef, also known as bovine insulin, has historically been used for the treatment of diabetes before the availability of human insulin and synthetic insulin analogs. However, the use of insulin beef has diminished over time, and human insulin or synthetic analogs are now more commonly employed. The primary use of insulin beef was for the management of diabetes in individuals who required insulin replacement therapy.
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