Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Nexcede
Synonyms :
ketoprofen
Class :
NSAID
Brand Name :
Nexcede
Synonyms :
ketoprofen
Class :
NSAID
Dosage Forms & Strengths
Oral film
12.5mg
ER capsules
200 mg
Capsule/Tablet
75 mg
50 mg
Pain
25-50 mg IR orally every 8 hours daily
or
200 mg ER orally daily
Immediate release:
25 - 50
mg
Tablet
Orally
every 8 hrs
Extended release-200mg orally every day
Immediate release:
75
mg
Tablet
Orally
every 8 hrs
50mg orally every 6 hours
Extended release-200mg orally every day
Immediate release:
25 - 50
mg
Tablet
Orally
every 8 hrs
when combined may increase anticoagulation
may diminish the effects of ketoprofen by pharmacodynamic antagonism
may diminish the effects of ketoprofen by pharmacodynamic antagonism
may diminish the effects of ketoprofen by pharmacodynamic antagonism
May enhances the effects of the other by pharmacodynamic synergism
may increase the level of each other by an unknown mechanism
May diminish the effects of ketoprofen by pharmacodynamic antagonism
may diminish the effects of ketoprofen by pharmacodynamic antagonism
May diminish the effects of ketoprofen by pharmacodynamic antagonism
interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity
interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity
the toxicity of either of the drugs is increased due to pharmacokinetic synergism
it enhances the serum potassium levels
May diminish the effects of ketoprofen by pharmacodynamic antagonism
it enhances the serum potassium levels
May diminish the effects of ketoprofen by pharmacodynamic antagonism
when combined may increase anticoagulation
when combined may increase anticoagulation
May diminish the effects of ketoprofen by pharmacodynamic antagonism
it enhances the serum potassium levels
may increase the level of each other by an unknown mechanism
when combined may increase anticoagulation
when combined may increase anticoagulation
it enhances the serum potassium levels
may increase the level of each other by an unknown mechanism
When ketoprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When ketoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
ketoprofen leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When ketoprofen is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When ketoprofen is used together with adenine, this leads to a reduction in the ketoprofen’s metabolism
ketoprofen: it may decrease the excretion of CYP3A inhibitors
ketoprofen: it may decrease the excretion of CYP3A inhibitors
ketoprofen: it may decrease the excretion of CYP3A inhibitors
ketoprofen: it may decrease the excretion of CYP3A inhibitors
ketoprofen: it may decrease the excretion of CYP3A inhibitors
it enhances the serum potassium levels
it enhances the serum potassium levels
may increase the anticoagulation effect when combined
the toxicity of either of the drugs is increased due to pharmacokinetic synergism
the risk of gastrointestinal bleeding may be increased
May enhances the effects of the other by pharmacodynamic synergism
may enhance the renal tubular clearance for anionic drug competition
may enhance the renal tubular clearance for anionic drug competition
may diminish the effects of ketoprofen by pharmacodynamic antagonism
may enhance the renal tubular clearance for anionic drug competition
may enhance the renal tubular clearance for anionic drug competition
Actions and Spectrum:
Action:
Ketoprofen blocks COX enzymes specifically COX-1 & COX-2 reducing prostaglandin production and relieving pain, inflammation, and fever.
Spectrum:
The spectrum of activity of this drug is beneficial to treat rheumatoid arthritis, acute gout, and osteoarthritis.
The drug primarily reduces inflammation, relieves pain & fever.
Frequency defined
>10%
Dyspepsia (12%)
Increased liver function test (up to 15%)
1-10%
Constipation (>3%)
Abdominal pain (>3%)
Diarrhea (>3%)
Nausea (>3%)
Impaired renal function disorder (3-9%)
Dizziness (3-9%)
<1%
Gastrointestinal perforation (<1%)
Gastrointestinal hemorrhage (<1%)
Stevens-Johnson syndrome (<0.1%)
Hypertension (<1%)
Congestive heart failure (<1%)
Contraindications/Caution:
Hypersensitivity
Asthma
Active peptic ulcers
History of heart problem
Blood clotting disorders
Severe liver & kidney disease
Pregnancy Warnings:
Pregnancy category: Not assigned
Lactation:
Excretion of the drug into human breast milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Ketoprofen works on the inhibition of prostaglandin formation hence it is beneficial in reducing swelling, redness and inflammation.
Ketoprofen lowers fever by reducing prostaglandin synthesis in the brain, regulating body temperature.
It can inhibit platelet aggregation, potentially increasing bleeding risk, though less than aspirin.
Pharmacokinetics:
Absorption
Peak plasma concentrations of ketoprofen can be reached in one to two hours, indicating good absorption.
Distribution
The distribution of ketoprofen in the body is good with most of the distribution occurs in synovial fluid where it exerts its anti-inflammatory effects.
Metabolism
The metabolism of ketoprofen occurs in liver.
Excretion and Elimination
The byproducts are excreted through urine and lesser portion excreted through feces.
Administration:
The medication is taken orally.
Ketoprofen is often available in tablet or capsule form.
Patient information leaflet
Generic Name: ketoprofen
Why do we use ketoprofen?
Ketoprofen is a NSAID which is used for various conditions like arthritis, dental pain, headaches, and musculoskeletal disorders.
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