Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Myciguent, Neo-Fradin, Mycifradin
Synonyms :
neomycin oral
Class :
Aminoglycosides
Brand Name :
Myciguent, Neo-Fradin, Mycifradin
Synonyms :
neomycin oral
Class :
Aminoglycosides
Dosage Forms & Strengths  Â
Oral (solution)Â
25mg/mlÂ
TabletÂ
500 mgÂ
3 g/day orally divided for each 6 hour
Acute: 4 to 12 g/day orally divided every 6 hour for 5 to 6 days OR 3 to 6 g/day for 1 to 2 weeks Chronic: orally up to 4 g/day
Dosage Forms & Strengths  Â
Oral (solution)Â
25mg/mlÂ
TabletÂ
500 mgÂ
50 to 100 mg/kg/day orally divided every 8 hours for 5 to 6 days, maximum up to 12 g daily
90 mg/kg/day orally divided for each 4 hour up to 2 to 3 days
50mg/kg/day orally divided for each 6 hour up to 2 to 3 days
Refer to adult dosingÂ
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with colistimethate
lansoprazole, amoxicillin, and clarithromycin
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
there may be an increased risk of renal impairment
they increase the nephrotoxicity of other aminoglycosides
neomycin/polymyxin B/bacitracin topical
they increase the nephrotoxicity of other aminoglycosides
they increase the nephrotoxicity of other aminoglycosides
they increase the nephrotoxicity of other aminoglycosides
they increase the nephrotoxicity of other aminoglycosides
neomycin PO and acyclovir both cause increased ototoxicity and/or nephrotoxicity
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
neomycin/polymyxin B/gramicidin ophthalmicÂ
may increase the nephrotoxic effect of Polymyxin B
they increase the nephrotoxicity of other aminoglycosides
neomycin/polymyxin B/bacitracin topical
they increase the nephrotoxicity of other aminoglycosides
they increase the nephrotoxicity of other aminoglycosides
they increase the nephrotoxicity of other aminoglycosides
they increase the nephrotoxicity of other aminoglycosides
it increases the nephrotoxicity of aminoglycosides
it increases the nephrotoxicity of aminoglycosides
aminoglycosides increase the effect of neuromuscular blockage of mecamylamine
the adverse/toxic effects of aminoglycosides may be heightened by ataluren
the nephrotoxic effects of aminoglycosides may be enhanced by mannitol
may enhance the renal tubular clearance for anionic drug competition
aminoglycosides increase the effect of hypocalcemia of bisphosphonate derivatives
aminoglycosides increase the effect of hypocalcemia of bisphosphonate derivatives
aminoglycosides increase the effect of hypocalcemia of bisphosphonate derivatives
aminoglycosides increase the effect of hypocalcemia of bisphosphonate derivatives
aminoglycosides increase the effect of hypocalcemia of bisphosphonate derivatives
may diminish the concentration of serum when combined with cardiac glycosides
may diminish the concentration of serum when combined with cardiac glycosides
may diminish the concentration of serum when combined with cardiac glycosides
may have an increased therapeutic effect when combined with neuromuscular blocking drugs
may have an increased therapeutic effect when combined with neuromuscular blocking drugs
may have an increased therapeutic effect when combined with neuromuscular blocking drugs
may have an increased therapeutic effect when combined with neuromuscular blocking drugs
may have an increased therapeutic effect when combined with neuromuscular blocking drugs
may have an increased therapeutic effect when combined with neuromuscular-blocking agents
The harmful/toxic effect of aminoglycosides may be intensified by loop diuretics
The harmful/toxic effect of aminoglycosides may be intensified by loop diuretics
The harmful/toxic effect of aminoglycosides may be intensified by loop diuretics
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may diminish the therapeutic effect of drug
may diminish the therapeutic effect of drug
may diminish the therapeutic effect of drug
may reduce the rate of excretion of aminoglycosides
may reduce the rate of excretion of aminoglycosides
may reduce the rate of excretion of aminoglycosides
may reduce the rate of excretion of aminoglycosides
may reduce the rate of excretion of aminoglycosides
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cyclosporine
Penicillins: they may diminish the serum concentration of aminoglycosides
amoxicillin and clavulanate potassium
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
may reduce the therapeutic effect of typhoid Vaccine
it increases the nephrotoxicity of aminoglycosides
it increases the nephrotoxicity of aminoglycosides
it increases the effect of neuromuscular blockage of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased adverse/toxic effect when combined with aminoglycosides
may have an increased adverse/toxic effect when combined with aminoglycosides
may have an increased adverse/toxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
may diminish the serum concentration when combined with aminoglycosides
may diminish the serum concentration when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
aminoglycosides may intensify the neuromuscular-blocking effect of botulinum toxin-containing products
aminoglycosides' nephrotoxic effect may be intensified by amphotericin B
aminoglycosides may augment the ototoxic effect of carboplatin, particularly with higher doses of carboplatin
may diminish the excretion when combined with aminoglycosides
Actions and Spectrum:Â
It works by attaching to the bacterial 30S ribosomal subunit and blocking the assembly of useful protein complexes to suppress bacterial protein production.Â
neomycin has a wide range of activity, although its main targets are gram-negative bacteria like Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Moreover, it exhibits modest efficacy against gram-positive bacteria such Streptococcus pyogenes and Staphylococcus aureusÂ
Frequency defined Â
<1%Â
NephrotoxicityÂ
DyspneaÂ
NeurotoxicityÂ
Ototoxicity (auditory, vestibular)Â
EosinophiliaÂ
>10%Â
Irritation or soreness of mouth or rectal areaÂ
DiarrheaÂ
Contact dermatitis (topical)Â
Nausea/vomitingÂ
Black Box WarningÂ
Although the oral medication neomycin does not have a black box warning, it does include the possibility of significant and permanent nephrotoxicity and ototoxicity. Â
Patients who have poor renal function or pre-existing hearing loss, as well as those who take large doses of neomycin or undergo extended therapy, are more likely to experience these side effects.Â
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
PharmacologyÂ
An aminoglycoside antibiotic called neomycin The medication inhibits protein synthesis in sensitive bacteria by attaching to the 30S ribosomal subunit of bacteria. Consequently, the germs are killed, and the illness is cleared up.Â
PharmacodynamicsÂ
neomycin’s pharmacodynamics as oral medication includes its contact with bacterial cells, which prevents protein production. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa are just a few of the gram-negative bacteria that neomycin is most effective against.
Although while it is often less efficient against gram-positive bacteria than gram-negative bacteria, it also has some action against gram-positive bacteria including Staphylococcus aureus and Streptococcus pyogenes.Â
PharmacokineticsÂ
Absorption  Â
neomycin is poorly absorbed from the gastrointestinal tract when taken via oral route.Â
DistributionÂ
neomycin remains primarily in the gastrointestinal tract and is not extensively distributed to other tissues. Â
MetabolismÂ
neomycin is eliminated intact in the urine since it is not digested by the body.Â
Elimination and excretionÂ
neomycin is eliminated by the kidneys, with some liver excretion as well. The medication has an elimination half-life of around 2 to 3 hours and is eliminated unaltered in urine.Â
Administration: Â
To maximize absorption, it is normally advised to take neomycin orally on an empty stomach at least 1 hour before or 2 hours after a meal. To assist avoid dehydration, it’s also necessary to consume a lot of liquids when taking neomycin.Â
Patient information leafletÂ
Generic Name: neomycin oralÂ
Why do we use neomycin oral?Â
neomycin is an antibiotic that belongs to the aminoglycoside class and is mostly used to treat gastrointestinal tract infections, including those that cause hepatic coma, intestinal stasis, and traveller’s diarrhoea. Prior to surgery, it is also used to prevent the formation of germs in the intestine.Â
neomycin causes the death of bacterial cells by attaching to bacterial ribosomes and interfering with protein production. Its systemic application is, however, constrained due to low absorption from the gastrointestinal tract, and it is largely employed for its local action in the stomach.Â
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