Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Onon
Synonyms :
pranlukast
Class :
Anti-Asthmatic Agents Leukotriene Antagonists
Brand Name :
Onon
Synonyms :
pranlukast
Class :
Anti-Asthmatic Agents Leukotriene Antagonists
Dosage forms and strengths Â
Oral powderÂ
Oral capsuleÂ
The recommended dose is 225 mg twice a day
The recommended dose is 225 mg twice a day
Dosage forms and strengths Â
Oral powderÂ
Oral capsuleÂ
Child: The recommended dose is 3.5 mg/kg twice a dayÂ
The maximum suggested dose is 10 mg/kg/dayÂ
(Keeping the daily intake below 450 mg is recommended)Â
Refer adult dosingÂ
Combining artemether with pranlukast may cause a reduction in the artemether’s metabolism
Combining asunaprevir with pranlukast may cause a reduction in the asunaprevir’s metabolism
Combining avapritinib with pranlukast may cause a reduction in the avapritinib's metabolism
Combining azelastine with pranlukast may cause a reduction in the azelastine metabolism
Combining bexarotene with pranlukast may cause a reduction in the bexarotene’s metabolism
Combining bortezomib with pranlukast may cause a reduction in the bortezomib’s metabolism
Combining bosentan with pranlukast may cause a reduction in the bosentan’s metabolism
Combining brivaracetam with pranlukast may cause a reduction in the brivaracetam’s metabolism
Combining buprenorphine with pranlukast may cause a reduction in the buprenorphine’s metabolism
Combining bupropion with pranlukast may cause a reduction in the bupropion’s metabolism
Combining cabozantinib with pranlukast may cause a reduction in the cabozantinib’s metabolism
Combining cannabidiol with pranlukast may cause a reduction in the cannabidiol’s metabolism
Combining celecoxib with pranlukast may cause a reduction in the celecoxib’s metabolism
Combining chlorpropamide with pranlukast may cause a reduction in the chlorpropamide’s metabolism
Combining cinnarizine with pranlukast may cause a reduction in the cinnarizine’s metabolism
Combining clopidogrel with pranlukast may cause a reduction in the clopidogrel’s metabolism
Combining cyclophosphamide with pranlukast may cause a reduction in the cyclophosphamide’s metabolism
Combining dacomitinib with pranlukast may cause a reduction in the dacomitinib’s metabolism
Combining dapagliflozin with pranlukast may cause a reduction in the dapagliflozin’s metabolism
Combining dapsone with pranlukast may cause a reduction in the dapsone’s metabolism
Combining desogestrel with pranlukast may cause a reduction in the desogestrel’s metabolism
Combining dexibuprofen with pranlukast may cause a reduction in the dexibuprofen’s metabolism
Combining dextromethorphan with pranlukast may cause a reduction in the dextromethorphan’s metabolism
Combining diazepam with pranlukast may cause a reduction in the diazepam’s metabolism
Combining diclofenac with pranlukast may cause a reduction in the diclofenac’s metabolism
Combining dicoumarol with pranlukast may cause a reduction in the dicoumarol’s metabolism
Combining diphenhydramine with pranlukast may cause a reduction in the diphenhydramine’s metabolism
Combining donepezil with pranlukast may cause a reduction in the donepezil’s metabolism
Combining doxazosin with pranlukast may cause a reduction in the doxazosin’s metabolism
Combining doxepin with pranlukast may cause a reduction in the doxepin’s metabolism
Combining estradiol with pranlukast may cause a reduction in the estradiol’s metabolism
Combining ethinylestradiol with pranlukast may cause a reduction in the ethinylestradiol’s metabolism
Combining etodolac with pranlukast may cause a reduction in the etodolac’s metabolism
Combining etoricoxib with pranlukast may cause a reduction in the etoricoxib’s metabolism
Combining flunarizine with pranlukast may cause a reduction in the flunarizine’s metabolism
Combining fluoxetine with pranlukast may cause a reduction in the fluoxetine’s metabolism
Combining fluvastatin with pranlukast may cause a reduction in the fluvastatin’s metabolism
Combining glimepiride with pranlukast may cause a reduction in the glimepiride’s metabolism
Combining halothane with pranlukast may cause a reduction in the halothane’s metabolism
Combining Ibuprofen with pranlukast may cause a reduction in the Ibuprofen’s metabolism
Combining Indomethacin with pranlukast may cause a reduction in the Indomethacin’s metabolism
Combining ketorolac with pranlukast may cause a reduction in the ketorolac’s metabolism
Combining leflunomide with pranlukast may cause a reduction in the leflunomide’s metabolism
Combining losartan with pranlukast may cause a reduction in the losartan’s metabolism
Combining mefenamic acid with pranlukast may cause a reduction in the mefenamic acid’s metabolism
Combining meloxicam with pranlukast may cause a reduction in the meloxicam’s metabolism
Combining mephenytoin with pranlukast may cause a reduction in the mephenytoin’s metabolism
Combining methadone with pranlukast may cause a reduction in the methadone’s metabolism
Combining montelukast with pranlukast may cause a reduction in the montelukast’s metabolism
Combining naproxen with pranlukast may cause a reduction in the naproxen’s metabolism
Combining ondansetron with pranlukast may cause a reduction in the ondansetron’s metabolism
Combining phenobarbital with pranlukast may cause a reduction in the phenobarbital’s metabolism
Combining abrocitinib with pranlukast may cause a reduction in the abrocitinib’s metabolism
Combining acenocoumarol with pranlukast may cause a reduction in the acenocoumarol’s metabolism
Combining acetohexamide with pranlukast may cause a reduction in the acetohexamide metabolism
Combining acetylsalicylic acid with pranlukast may cause a reduction in the acetylsalicylic acid metabolism
Combining alosetron with pranlukast may cause a reduction in the alosetron’s metabolism
Combining aminophenazone with pranlukast may cause a reduction in the aminophenazone’s metabolism
Combining amitriptyline with pranlukast may cause a reduction in the amitriptyline’s metabolism
Combining antipyrine with pranlukast may cause a reduction in the antipyrine metabolism
Combining apixaban with pranlukast may cause a reduction in the apixaban metabolism
Combining arformoterol with pranlukast may cause a reduction in the arformoterol’s metabolism
Actions and Spectrum:Â
Action:Â
Leukotriene Receptor Antagonism: pranlukast works by blocking the activity of leukotrienes, which are inflammatory molecules released in response to allergens and other triggers. Specifically, it antagonizes the cysteinyl leukotriene receptors (CysLT1 receptors). By inhibiting these receptors, pranlukast helps to reduce the bronchoconstriction, inflammation, and mucus production associated with asthma and allergic rhinitis.Â
Spectrum:Â
Asthma: pranlukast is prescribed as a maintenance therapy for asthma, especially for individuals with mild to moderate persistent asthma. It helps prevent and control asthma symptoms such as wheezing, shortness of breath, and coughing. It is often used with other asthma medications like inhaled corticosteroids or short-acting beta-agonists.Â
Allergic Rhinitis: pranlukast is also effective in managing allergic rhinitis, commonly known as hay fever.
Frequency not defined Â
unusual tirednessÂ
weaknessÂ
stuffy noseÂ
skin rashÂ
heartburnÂ
headacheÂ
coughÂ
abdominal painÂ
Black Box Warning:Â Â
None Â
Contraindication/Caution:Â Â
Hypersensitivity: Individuals with a known hypersensitivity or allergic reaction to pranlukast or any of its components should not use this medication.Â
Pregnancy: pranlukast should be employed during pregnancy solely when the potential advantages outweigh the potential risks to the developing fetus. It is essential to consult with a healthcare provider before contemplating the use of pranlukast during pregnancy.Â
Breastfeeding: It is not well-established whether pranlukast is excreted in human breast milk. Therefore, caution should be exercised when using pranlukast while breastfeeding. A healthcare provider can help weigh the risks and benefits in such cases.Â
Severe Hepatic Impairment: pranlukast is metabolized by the liver, so individuals with severe hepatic (liver) impairment may need dosage adjustments or should avoid this medication altogether. A healthcare provider should determine the appropriate course of action.Â
Children Under Specific Age: pranlukast’s safety and efficacy in children below a certain age may not be well-established, and therefore, it may be contraindicated in very young children. The exact age limit may vary based on the formulation and local guidelines, so following your healthcare provider’s advice is essential.Â
Allergic Reactions: If a patient has experienced an allergic reaction or severe side effects while taking pranlukast or similar drugs in the past, it is contraindicated.
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â Â
pranlukast is a medication primarily used to manage and alleviate asthma and allergic rhinitis symptoms.Â
Pharmacodynamics:Â Â
pranlukast works by blocking the action of leukotrienes, specifically leukotriene D4 (LTD4), and leukotriene E4 (LTE4). It does this by binding to and inhibiting the leukotriene receptors CysLT1 (Cysteinyl leukotriene receptor 1). By blocking these receptors, pranlukast reduces the inflammatory response in the airways and nasal passages, leading to bronchodilation (widening of the airways) and decreased mucus production. Â
Pharmacokinetics:Â
AbsorptionÂ
pranlukast is orally administered and is well-absorbed from the gastrointestinal tract.Â
DistributionÂ
It is distributed throughout the body, including the lungs, where it exerts its therapeutic effects.Â
MetabolismÂ
pranlukast undergoes metabolism in the liver, primarily by the cytochrome P450 enzyme system.Â
Excretion and EliminationÂ
The majority of the drug’s metabolites and excretion occurs through urine.Â
Administration: Â
pranlukast is commonly administered orallyÂ
Patient information leafletÂ
Generic Name: pranlukastÂ
Why do we use pranlukast? Â
Asthma: pranlukast is prescribed to individuals with asthma,It helps in preventing asthma symptoms such as wheezing, shortness of breath, and coughing by blocking the action of leukotrienes, which are substances that cause airway inflammation and constriction.Â
Allergic Rhinitis: pranlukast can also be used to manage allergic rhinitis, an allergic reaction primarily affecting the nasal passages. It can alleviate symptoms like sneezing, runny or stuffy nose, and itching by reducing the inflammatory response triggered by allergens.Â
Exercise-Induced Bronchoconstriction (EIB): Some individuals, especially athletes, experience bronchoconstriction or narrowing of the airways because of physical activity. pranlukast may be prescribed to prevent or reduce exercise-induced bronchoconstriction, allowing individuals to engage in physical activities without experiencing asthma symptoms.Â
Chronic Obstructive Pulmonary Disease: In some cases, pranlukast may be considered as an adjunctive therapy for individuals with COPD, a chronic lung condition that includes chronic bronchitis and emphysema. It can help manage symptoms related to airway inflammation and bronchoconstriction.Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
