Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
serdolect
Synonyms :
sertindole
Class :
Antipsychotics
Brand Name :
serdolect
Synonyms :
sertindole
Class :
Antipsychotics
Dosage forms and strengths Â
Tablets Â
4 mgÂ
12 mgÂ
16 mgÂ
20 mgÂ
For a patient who cannot tolerate any other antipsychotic medication
At start, take 4 mg one time a day raised slowly every four to five days in increments of 4 mg
The maintenance dose is 12 mg to 20 mg one time a day
The maximum dose is 24 mg in a day
If therapy is stopped for more than one week, re-titrate the dosage
Not indicatedÂ
Refer adult dosingÂ
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
CYP3A4 Inhibitors (Moderate) may increase the serum concentration when combined with Sertindole
CYP3A4 Inhibitors (Moderate) may increase the serum concentration when combined with Sertindole
CYP3A4 Inhibitors (Moderate) may increase the serum concentration when combined with Sertindole
CYP3A4 Inhibitors (Moderate) may increase the serum concentration when combined with Sertindole
CYP3A4 Inhibitors (Moderate) may increase the serum concentration when combined with Sertindole
may increase the QTc-prolonging effect of QT-prolonging Agents
may increase the QTc-prolonging effect of QT-prolonging Agents
may increase the QTc-prolonging effect of QT-prolonging Agents
may increase the QTc-prolonging effect of QT-prolonging Agents
may increase the QTc-prolonging effect of QT-prolonging Agents
may have an increased QTc-prolonging effect when combined with QT-prolonging agents
may have an increased QTc-prolonging effect when combined with QT-prolonging agents
may have an increased QTc-prolonging effect when combined with QT-prolonging agents
may have an increased QTc-prolonging effect when combined with QT-prolonging agents
sertindole: they may enhance the serum concentration of CYP3A Inhibitors
sertindole: they may enhance the serum concentration of CYP3A Inhibitors
sertindole: they may enhance the serum concentration of CYP3A Inhibitors
sertindole: they may enhance the serum concentration of CYP3A Inhibitors
sertindole: they may enhance the serum concentration of CYP3A Inhibitors
CYP3A strong enhancers of the small intestine may reduce the bioavailability of sertindole
it increases the effect of QT-prolonging agents
it increases the QTc prolongation of QT-prolonging agents
may increase the Qt prolonging effect
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the adverse/toxic effect of amphetamines
may enhance the adverse/toxic effect of amphetamines
may enhance the adverse/toxic effect of amphetamines
may enhance the adverse/toxic effect of amphetamines
may enhance the adverse/toxic effect of amphetamines
It may enhance the metabolism when combined with dexamethasone
serotonergic Agents may enhance the adverse/toxic effect of antipsychotic Agents
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
antipsychotic agents may enhance the adverse/toxic effect of amphetamines
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may enhance the effect of antipsychotic agents
may enhance the effect of antipsychotic agents
may enhance the effect of antipsychotic agents
may enhance the effect of antipsychotic agents
may enhance the effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
When sertindole is used together with acetazolamide, this leads to enhanced risk or seriousness of CNS depression
When sertindole is used together with acetophenazine, this leads to enhanced risk or seriousness of CNS depression
When sertindole is used together with agomelatine, this leads to enhanced risk or seriousness of CNS depression
When sertindole is used together with alfentanil, this leads to enhanced risk or seriousness of CNS depression
When sertindole is used together with alimemazine, this leads to enhanced risk or seriousness of CNS depression
When sertindole is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Actions and Spectrum:Â
Action:Â
Dopamine Receptor Antagonism: Sertindole acts as an antagonist primarily at D2 and D3 dopamine receptors. By blocking these receptors, it modulates dopamine activity in the brain, which is associated with its antipsychotic effects.Â
Serotonin Receptor Antagonism: Sertindole also acts as an antagonist at serotonin receptors, particularly 5-HT2A and 5-HT2C receptors. This action is thought to contribute to its efficacy in managing psychotic symptoms.Â
Spectrum:Â
Antipsychotic Effects: Sertindole’s spectrum of action revolves around managing psychotic symptoms such as hallucinations, delusions, disorganized thinking, and emotional withdrawal in conditions like schizophrenia.Â
Mood Stabilization: While primarily used for schizophrenia, some research suggests it may also have a role in mood stabilization.Â
Â
Frequency not defined Â
ParaesthesiaÂ
Neuroleptic malignant syndromeÂ
Nasal congestionÂ
Movement disturbancesÂ
HyperprolactinaemiaÂ
HyperglycaemiaÂ
HaematuriaÂ
GalactorrhoeaÂ
Failure of ejaculationÂ
Exacerbation of diabetesÂ
Erectile dysfunctionÂ
Ejaculation disordersÂ
DyspnoeaÂ
Dry mouthÂ
DizzinessÂ
ConvulsionsÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Known hypersensitivity: Individuals who have previously shown hypersensitivity or allergic reactions to sertindole or any of its components should avoid using this medication.Â
Severe cardiovascular disorders: Patients with known severe cardiovascular conditions (e.g., recent myocardial infarction, heart failure, arrhythmias) may be at increased risk of complications when taking sertindole.Â
Hepatic impairment: Sertindole is metabolized in the liver. Patients with severe hepatic impairment may experience increased concentrations of sertindole, potentially leading to adverse effects. Caution and dose adjustment are necessary in individuals with hepatic impairment.Â
Renal impairment: While renal impairment doesn’t have a direct contraindication, patients with severe renal impairment may need to alter their dosage and exercise caution as sertindole and its metabolites can be excreted through the kidneys.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is knownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Sertindole is an atypical antipsychotic medication used in the treatment of schizophrenia.Â
Pharmacodynamics:Â Â
Dopamine D2 receptor antagonism: Sertindole blocks dopamine D2 receptors in the brain. By doing so, it helps to reduce the excessive dopamine activity often associated with symptoms of schizophrenia.Â
Serotonin 5-HT2A receptor antagonism: Sertindole also blocks serotonin 5-HT2A receptors. Modulating serotonin activity is thought to contribute to its antipsychotic effects. Â
Pharmacokinetics:Â
AbsorptionÂ
Sertindole is well-absorbed orally after administration, reaching peak plasma concentrations in approximately 3 to 4 hours.Â
DistributionÂ
It has a high binding capacity to plasma proteins (about 99%), primarily binding to alpha-1-acid glycoprotein and albumin.Â
Sertindole crosses the blood-brain barrier and distributes into various tissues within the body.Â
MetabolismÂ
Sertindole is extensively metabolized in the liver primarily by the enzyme CYP3A4.Â
Excretion and EliminationÂ
After metabolism, the metabolites are mainly excreted through the feces (about 80%) and urine (about 7%).Â
The elimination half-life of sertindole is approximately 60 to 70 hours, indicating a relatively long duration of action.Â
Administration: Â
Sertindole is usually taken orally in the form of tablets. Â
It can be taken with or without food.Â
Patient information leafletÂ
Generic Name: sertindoleÂ
Why do we use sertindole? Â
Sertindole is prescribed to manage symptoms of schizophrenia, including hallucinations, delusions, disorganized thinking, and emotional withdrawal. It can be used to alleviate symptoms in other psychotic disorders, though its primary application is for schizophrenia.Â
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