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Brand Name :
Tridione
Synonyms :
trimethadione
Class :
Oxazolidinedione Anticonvulsants
Brand Name :
Tridione
Synonyms :
trimethadione
Class :
Oxazolidinedione Anticonvulsants
Dosage Forms & StrengthsÂ
TabletÂ
150mgÂ
300mgÂ
Initial dose-Administer 900 mg orally, three to four times a day, in divided doses.
This dose can be increased by 300 mg weekly until therapeutic effects are noticed or toxic symptoms occur.
Maintenance dose- Administer 900 to 2400mg orally, three to four times daily, in divided doses.
Dosage Forms & StrengthsÂ
TabletÂ
150mgÂ
300mgÂ
In divided doses, administer 300 to 900 mg orally three to four times daily.
Refer adult dosingÂ
may enhance the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may enhance the risk of hypoglycemia when combined
may enhance the risk of hyperglycemia when combined
may increase the risk of hypoglycemia when combined
may increase the risk of hypoglycemia when combined
may increase the risk of hyperglycemia when combined
may increase the risk of hyperglycemia when combined
may enhance the arrhythmogenic activities of each other when combined
may enhance the arrhythmogenic activities of each other when combined
may enhance the arrhythmogenic activities of each other when combined
may increase the risk of CNS depression when combined
may increase the risk of CNS depression when combined
may increase the risk of CNS depression when combined
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
the risk or severity of hyperkalemia may increase when trimethadione is combined with isoxicam
the risk of adverse effects may be heightened when trimethadione is combined with rimonabant
the neuromuscular blocking activities of tubocurarine may be heightened by trimethadione
it decreases the efficacy of antiseizure agents
- may increase the toxic effect of antipsychotic agents
may increase the toxic effect of Antipsychotic Agents
may increase the metabolism of each other when it is combined
the risk of CNS depression may be increased
Actions and Spectrum:Â
trimethadione is an anticonvulsant medication used to treat certain types of seizures, particularly absence seizures (petit mal seizures). Â
The spectrum of activity of trimethadione is primarily focused on treating absence seizures. Absence seizures are characterized by brief lapses of consciousness, sometimes with subtle body movements or blinking.
Frequency not definedÂ
VomitingÂ
Gastric distressÂ
FatigueÂ
SleeplessnessÂ
EpistaxisÂ
Skin rashÂ
RednessÂ
NauseaÂ
Abdominal painÂ
DrowsinessÂ
UneasinessÂ
Bleeding gumsÂ
Retinal and petechial bleedingÂ
Skin inflammationÂ
Black box warning:Â
NoneÂ
Contraindications/caution:Â
Contraindications:Â
Caution:Â
Pregnancy consideration: trimethadione may pose risks to the developing fetus and should not be used during pregnancy unless the potential benefits outweigh the risks.Â
Lactation: Excretion of the drug in human breast milk is known.Â
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
trimethadione is an anticonvulsant medication used primarily to treat absence seizures (petit mal seizures) in patients with epilepsy. Its pharmacological properties involve interactions with various neural pathways and neurotransmitter systems in the brain.Â
Pharmacokinetics:Â
AbsorptionÂ
trimethadione is administered orally in the form of tablets or capsules. It is readily absorbed from the gastrointestinal tract into the bloodstream.Â
DistributionÂ
trimethadione, including the central nervous system (CNS), is distributed throughout the body. It can cross the blood-brain barrier, crucial for its anticonvulsant effects.Â
MetabolismÂ
trimethadione undergoes extensive hepatic metabolism in the liver. The primary metabolic pathway involves the formation of metabolites, including dimethadione and mono-hydroxy trimethadione. These metabolites are thought to contribute to the drug’s anticonvulsant activity.Â
Elimination and ExcretionÂ
The metabolites of trimethadione are primarily excreted in the urine. Only a tiny portion of the drug and its metabolites are excreted in the feces.Â
Administration:Â
Oral administrationÂ
trimethadione is taken orally with or without food.Â
Patient information leafletÂ
Generic Name: trimethadioneÂ
Why do we use trimethadione?Â
trimethadione is an anticonvulsant medication primarily used to treat certain types of seizures, particularly absence seizures (petit mal seizures), in patients with epilepsy.
The primary use of trimethadione is to help manage and control these specific seizure types. Absence seizures are characterized by brief episodes of unconsciousness or “spacing out,” often lasting only a few seconds.Â
trimethadione helps reduce the frequency and severity of absence seizures by stabilizing neural activity in the brain, particularly in areas responsible for generating these specific seizure types.Â
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