Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Levate, Elavil
Synonyms :
amitriptyline
Class :
Antidepressants and antianxiety drugs; norepinephrine reuptake inhibitors
Brand Name :
Levate, Elavil
Synonyms :
amitriptyline
Class :
Antidepressants and antianxiety drugs; norepinephrine reuptake inhibitors
Dosage forms & Strengths
Tablet
10 mg
25 mg
50 mg
75 mg
100 mg
150 mg
OP:
25-50 mg orally every night at bedtime
May increase up to 25 mg for every 5-7 days; following 100-200 mg daily
And may increase 300 mg/day if required
IP:
100-300 mg orally daily
OP:
25-50 mg orally every night at bedtime
May increase up to 25 mg for every 5-7 days; following 100-200 mg daily
And may increase 300 mg/day if required
IP:
100-300 mg orally daily
65 - 100
mg
Tablet
Orally 
every day
3
weeks
150
mg
Tablet
Orally 
at bedtime
8
weeks
10 - 25
mg
Orally 
at bedtime
10-400 mg Orally at bedtime dose range
Dosage forms & Strengths
Tablet
10 mg
25 mg
50 mg
75 mg
100 mg
150 mg
Adolescents
25-50 mg orally daily in divided doses
May increase to 100 mg daily in divided doses
Children (Off-label)
On Day 1,2,3 1 mg/kg in divided doses 3 times daily
1.5 mg/kg in divided doses 3 times daily
refer adult dosing
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may increase the metabolism of tricyclic antidepressants
may have an increased risk of adverse effects when combined with amitriptyline
amitriptyline: it may increase the risk of methemoglobinemia agents
amitriptyline: it may increase the risk of methemoglobinemia agents
amitriptyline: it may increase the risk of methemoglobinemia agents
amitriptyline: it may increase the risk of methemoglobinemia agents
amitriptyline: it may increase the risk of methemoglobinemia agents
when both drugs are combined, there may be an increase in qtc interval  
may have an increased risk of adverse effects when combined with amitriptyline
It may enhance QTc interval when combined with pentamidine
may enhance the risk of gastrointestinal bleeding when combined with amitriptyline
may increase the risk of hypertension when combined
It may enhance QTc interval when combined with perphenazine
may increase cisapride's ability to cause irregular heartbeats
when both drugs are combined, both increase the QTC interval  
when combined, it may increase sedation
glycopyrrolate inhaled and formoterolÂ
may increase the QTc interval when combined
may enhance the risk or severity of gastrointestinal bleeding when combined
may have an increased effect of CNS depression when combined with Amitriptyline
May increase the anti-coagulant action when combined.
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may increase the vasopressor effect
It may reduce the effects when combined with pleurisy root by unspecified interactions mechanism
may enhance the tachycardic effect
may enhance the tachycardic effect
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
It may enhance sedation when combined with a shepherd's purse
It may enhance sedation when combined with codeine
it may diminish the therapeutic efficacy when combined with castor oil
It may enhance sedation when combined with oxycodone
batefenterol (Investigational)Â
The combination of batefenterol with amitriptyline may reduce the therapeutic effectiveness of batefenterol
it may enhance the sedation when combined with lofexidine
it may diminish the metabolism when combined with ciclesonide
The effectiveness of guanoxan's antihypertensive properties could be diminished by the presence of amitriptyline
it may diminish the metabolism when combined with diosmin
When metixene and amitriptyline are combined, the risk or seriousness of adverse events will rise
Combining amitriptyline with levobetaxolol might reduce the amitriptyline metabolism
The potential for increased CNS depression risk or seriousness occurs when amitriptyline is used together with pinazepam
Combining amitriptyline with pranlukast may cause a reduction in the amitriptyline’s metabolism
When amitriptyline is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When captodiame is used together with amitriptyline, There is a risk or seriousness of CNS depression is enhanced
When amitriptyline is used together with medazepam, the risk or seriousness of CNS depression is enhanced
amitriptyline may intensify paraldehyde's CNS depressant effects
When amitriptyline is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dexrabeprazole and amitriptyline is used together, this leads to reduction in the dexrabeprazole’s metabolism
amitriptyline: they may enhance the serum concentration of CYP2D6 Inhibitors
amitriptyline: they may enhance the serum concentration of CYP2D6 Inhibitors
amitriptyline: they may enhance the serum concentration of CYP2D6 Inhibitors
amitriptyline: they may enhance the serum concentration of CYP2D6 Inhibitors
amitriptyline: they may enhance the serum concentration of CYP2D6 Inhibitors
When amitriptyline is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When ponesimod is used together with amitriptyline, this leads to enhanced risk or seriousness of bradycardia
When amitriptyline is used together with amitriptyline, this leads to enhanced risk or seriousness of QTc prolongation
When amitriptyline is used together with isoflurophate, this leads to a reduction in the therapeutic effectiveness of amitriptyline
When amitriptyline is used together with givinostat, this leads to enhanced risk or severity of Qtc prolongation
When emylcamate is used together with amitriptyline, this leads to enhanced risk or seriousness of CNS depression
When amitriptyline is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When azatadine is used together with amitriptyline, this leads to enhanced risk or seriousness of adverse events
When amitriptyline is used together with bufexamac, this leads to enhanced risk or seriousness of gastrointestinal bleeding
amitriptyline leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of amitriptyline which leads to increased level of serum
amitriptyline leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
amitriptyline leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
amitriptyline leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
amitriptyline leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When indisulam is used together with amitriptyline, this leads to a reduction in amitriptyline metabolism
When amitriptyline is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
the therapeutic efficacy of amitriptyline may be reduced when used in conjunction with ambenonium
the adverse effects of amitriptyline may be increased when combined with cimetropium
When amitriptyline is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
amitriptyline: it may decrease activities of antihypertensive drugs
amitriptyline: it may decrease activities of antihypertensive drugs
amitriptyline: it may decrease activities of antihypertensive drugs
amitriptyline: it may decrease activities of antihypertensive drugs
amitriptyline: it may decrease activities of antihypertensive drugs
amitriptyline: it may decrease the metabolism of gestodene
amitriptyline: it may increase the risk or severity of QTc prolongation agents
amitriptyline: it may increase the risk or severity of QTc prolongation agents
amitriptyline: it may increase the risk or severity of QTc prolongation agents
amitriptyline: it may increase the risk or severity of QTc prolongation agents
amitriptyline: it may increase the risk or severity of QTc prolongation agents
amitriptyline may decrease the excretion rate of almasilate, potentially increasing serum levels
When amitriptyline is used together with diazoxide, this leads to reduction in diazoxide’s antihypertensive effects
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
It may lead to sedation, respiratory depression, and coma
It may lead to sedation, respiratory depression, and coma
It may lead to sedation, respiratory depression, and coma
when combined, it may increase sedation
barbiturates may increase the metabolism of tricyclic antidepressants
barbiturates may increase the metabolism of tricyclic antidepressants
barbiturates may increase the metabolism of tricyclic antidepressants
barbiturates may increase the metabolism of tricyclic antidepressants
barbiturates may increase the metabolism of tricyclic antidepressants
may enhance the risk or severity of hypertension when combined
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
sedative effects can be increased when amitriptyline is administered with papaverine
the efficacy of benzylpenicillolyl polylysine as a diagnostic agent may be decreased with amitriptyline
the risk of gastrointestinal bleeding may be increased
the risk of QTc prolongation may be increased
the therapeutic activity of amitriptyline may be reduced
the therapeutic efficacy of amitriptyline may be reduced when used in conjunction with ambenonium
an alteration in the therapeutic activity of either of the drugs may be seen
the therapeutic effect of pf- 00610355 may be reduced
when taken with fosnetupitant, amitriptyline's metabolism may be slowed down
the rate of metabolism of amitriptyline may be reduced
the rate of metabolism of amitriptyline may be reduced
amitriptyline may lower the hypoglycemic activities of insulin pork
the risk of CNS depression may be increased
the rate of metabolism may be altered
ceforanide: it may decrease the excretion rate of amitriptyline
the hypoglycemic effects of luseogliflozin may be reduced
lapatinib increases the effect of amitriptyline by altering the intestinal or hepatic CYP3A4 enzyme metabolism
Frequency undefined:Â
AgitationÂ
AgranulocytosisÂ
AlopeciaÂ
AnxietyÂ
AnorexiaÂ
AtaxiaÂ
ArrhythmiaÂ
Blurred visionÂ
ComaÂ
ConfusionÂ
DiarrheaÂ
DizzinessÂ
Dry mouthÂ
ECG changesÂ
EosinophiliaÂ
Extrapyramidal symptoms Â
HallucinationÂ
HeadacheÂ
Increased LFTsÂ
InsomniaÂ
LethargyÂ
LeukopeniaÂ
MIÂ
NauseaÂ
Orthostatic hypotensionÂ
PalpitationÂ
ParesthesiaÂ
PhotosensitivityÂ
RashÂ
RestlessnessÂ
SedationÂ
SeizureÂ
Sexual dysfunctionÂ
SIADHÂ
StrokeÂ
StomatitisÂ
SyncopeÂ
SweatingÂ
TachycardiaÂ
ThrombocytopeniaÂ
TinnitusÂ
Urinary retentionÂ
UrticariaÂ
VomitingÂ
XerostomiaÂ
WeaknessÂ
Weight gainÂ
Amitriptyline is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.Â
Pregnancy consideration:Â Â
Category C.Â
Breastfeeding warnings:Â Â
Avoid taking the medication during breastfeedingÂ
Pregnancy category:Â
Patient information leafletÂ
Generic Name:Â amitryptiline
Pronounced: ami-tryp-ti-line
Why do we use amitryptiline?Â
amitriptyline belongs to a class of drugs known as tricyclic antidepressants (TCAs). While its primary use is as an antidepressant, amitriptyline has several other applications due to its effects on the central nervous system.
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