Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Lipitor
Synonyms :
atorvastatin
Class :
Lipid-lowering agents, statins, HMG-CoA Reductase inhibitors
Brand Name :
Lipitor
Synonyms :
atorvastatin
Class :
Lipid-lowering agents, statins, HMG-CoA Reductase inhibitors
Dosage Forms & Strengths
Tablet:
10mg
20mg
40mg
80mg
Primary hypercholesterolemia and mixed dyslipidemia:
initial dose:10-20mg orally every day
maintenance dose:10-80mg orally every day
initial dose:
10 - 20
mg
Tablet
Orally
every day
maintenance dose:10-80mg orally every day
10
mg
Tablet
Orally
every day
Note:
Indicated for Patients with CHD to lower their risk of MI, stroke, angina, and hospitalization for CHF
lowering the risk of stroke, heart attack, and revascularization procedures in those with several risk factors other than diabetes but no signs of coronary heart disease (CHD)
Dosage Forms & Strengths
Tablet:
10mg
20mg
40mg
80mg
Heterozygous Familial Hypercholesterolemia
<10 years: Safety and efficacy not established
>10 years:10 mg orally every day-initially
Do not exceed 20mg orally every day
Homozygous familial hypercholesterolemia
<10 years: Safety and efficacy not established
>10 years:10-40mg orally every day
Refer adult dosing
may diminish the serum concentration when combined with tenapanor
when both drugs are combined, there may be an increase in the serum concentration of talazoparib
may increase the toxic effects of antibiotics
may diminish the serum concentration when combined with HMG-CoA reductase inhibitors (statins)
may enhance the serum concentration of simeprevir
may enhance the serum concentration of elbasvir/grazoprevir
may enhance the serum concentration of fostemsavir
may decrease the metabolism when combined
rifampin: they may enhance the serum concentration of atorvastatin
may increase the toxicity through anti-coagulation
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
It may diminish the metabolism when combined with dexamethasone
It may enhance toxicity when combined with cholic acid by diminishing the elimination
may enhance the concentration of serum when combined with atorvastatin
may enhance the concentration of serum when combined with atorvastatin
may enhance the concentration of serum when combined with atorvastatin
may enhance the concentration of serum when combined with atorvastatin
may enhance the concentration of serum when combined with atorvastatin
It may enhance the effect when combined with tafamidis meglumine
it may enhance the metabolism when combined with oxcarbazepine
Combining tegafur with atorvastatin can reduce tegafur’s metabolism
atorvastatin: they may enhance the serum concentration of CYP3A Inhibitors
atorvastatin: they may enhance the serum concentration of CYP3A Inhibitors
atorvastatin: they may enhance the serum concentration of CYP3A Inhibitors
atorvastatin: they may enhance the serum concentration of CYP3A Inhibitors
atorvastatin: they may enhance the serum concentration of CYP3A Inhibitors
When domeperidone and atorvastatin is used together, this leads to reduction in the domeperidone’s metabolism
When atorvastatin is used together with fluconazole, this leads to reduction in the atorvastatin metabolism
tinidazole has the potential to reduce the rate of excretion of atorvastatin, potentially leading to an elevation in level of serum
When indisulam is used together with atorvastatin, this leads to a reduction in atorvastatin metabolism
When atorvastatin is used together with adenine, this leads to a reduction in the atorvastatin's metabolism
the concentration of atorvastatin in the bloodstream can be raised when combined with filgotinib
when both drugs are combined, there may be a decreased metabolism of atorvastatin
when both drugs are combined, there may be a decreased metabolism of vincristine
when both drugs are combined, there may be a decreased metabolism of atorvastatin
when both drugs are combined, there may be a decreased metabolism of paclitaxel
when both drugs are combined, there may be a decreased metabolism of atorvastatin
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
the effect of atorvastatin is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
May increase serum level and toxic effects of docetaxel by affecting MDR1/PG-P efflux transporter
when both drugs are combined, there may be an increased risk or severity of adverse effects
increase the therapeutic effect of idarubicin by P-glycoprotein efflux transporter
may enhance the serum concentration
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may diminish the amount of P-glycoprotein (MDR1) efflux transporter
may enhance the concentration of serum when combined with atorvastatin
may enhance the serum concentration when combined
may increase the myopathic effect of HMG-CoA Reductase Inhibitors
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
amiodarone: they may enhance the serum concentration of atorvastatin
the rate of excretion of atorvastatin may be reduced
combining atorvastatin may result in a decreased excretion of cholecystokinin
the rate of metabolism of atorvastatin may be reduced
etravirine: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
quinine: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
simvastatin: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
voxilaprevir: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
lercanidipine: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
ranolazine: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
ticagrelor: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
verapamil: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
they decrease the absorption of fibric acid derivatives
bezafibrate increases the effect of myopathy on HMG-CoA reductase inhibitors
Actions and Spectrum:
Action
The action of atorvastatin is to block the enzyme responsible for producing cholesterol in the liver. This leads to a decrease in the production of LDL cholesterol, which is the primary source of plaque buildup in the arteries. By lowering LDL cholesterol levels, atorvastatin can help to reduce the risk of heart attacks and strokes
Spectrum
The spectrum of atorvastatin includes the treatment of high cholesterol and the prevention of heart disease. It is typically prescribed to people who have high LDL cholesterol levels, have a family history of heart disease, or have other risk factors for heart disease such as high blood pressure, diabetes, or smoking. Atorvastatin can also be used to lower the risk of heart attacks and strokes in people who have already had a heart attack or stroke.
Frequency defined
>10%
Diarrhea (5-14%)
Nasopharyngitis (4-13%)
Arthralgia (4-12%)
1-10%
Insomnia (1-5%)
Urinary tract infection (4-8%)
Nausea (4-7%)
Dyspepsia (3-6%)
Increased transaminases (2-3%)
Muscle spasms (2-5%)
Musculoskeletal pain (2-5%)
Myalgia (3-8%)
Limb pain (3-8%)
Pharyngolaryngeal pain (1-4%)
Frequency Not Defined
Angina
Syncope
Dyspnea
Myopathy
Anaphylaxis
Stevens-Johnson syndrome
Myositis
Black Box Warning:
The FDA has issued a black box warning for atorvastatin and other statins due to the risk of muscle damage (myopathy) and a rare but serious condition known as rhabdomyolysis.
Contraindication / Caution:
Contraindication:
Caution:
Pregnancy consideration: The safety of the drug is not established during pregnancy
Pregnancy category: X
Lactation: The excretion of the drug in human breast milk is unknown
Pregnancy category:
Pharmacology:
atorvastatin is a medication in the class of drugs known as statins. It is used to lower cholesterol levels in the blood and reduce the risk of heart disease and stroke.
Pharmacodynamics:
atorvastatin works by inhibiting the enzyme HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. This leads to a decrease in the levels of LDL (low-density lipoprotein) cholesterol, which is often referred to as “bad” cholesterol, and an increase in the levels of HDL (high-density lipoprotein) cholesterol, which is often referred to as “good” cholesterol. Atorvastatin also has anti-inflammatory and antioxidant properties.
Pharmacokinetics:
Absorption
Atorvastatin is well absorbed in the gastrointestinal tract
The peak plasma concentration is reached within 1-2 hours after oral administration.
Distribution
The Protein bound is 98% and volume of distribution (Vd) is 381 L
Metabolism
Metabolized in the liver by the enzyme CYP3A4
Elimination and excretion
Atorvastatin has a half-life of approximately 14 hours. Excretion through bile and urine (2%)
Administration:
Oral administration
atorvastatin is typically administered orally, usually once daily at bedtime. The dosage and duration of treatment will vary depending on the individual’s medical condition and response to treatment. It is important to take atorvastatin as directed by a healthcare provider and to not exceed the recommended dosage.
Patient information leaflet
Generic Name: atorvastatin
Pronounced: [ a-TOR-va-sta-tin]
Why do we use atorvastatin?
Atorvastatin is used to treat high blood cholesterol, maintain triglyceride levels and prevent CHD.
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