Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
N/A
Synonyms :
bufexamac
Class :
NSAID's
Brand Name :
N/A
Synonyms :
bufexamac
Class :
NSAID's
Adult Dosing
Dosage forms and strengths
Cream
5%
Inflammatory skin conditions
Apply the 5% cream topically to the areas of affected skin
Apply the 5 % cream topically to the areas of affected skin
Apply the 5% cream topically to the areas of affected skin
Not indicated
Refer adult dosing
When bufexamac is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When bufexamac is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When bufexamac is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
When bufexamac is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
bufexamac: it may increase the risk or severity of CNS depression
bufexamac: it may increase the risk or severity of CNS depression
bufexamac: it may increase the risk or severity of CNS depression
bufexamac: it may increase the risk or severity of CNS depression
bufexamac: it may increase the risk or severity of CNS depression
When bufexamac is used together with difenpiramide, this leads to increased risk or seriousness of adverse events
When aceclofenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When acemetacin is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When alclofenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When aminophenazone is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When antipyrine is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When antrafenine is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When bendazac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When amitriptyline is used together with bufexamac, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with acetylsalicylic acid, this leads to a reduction in therapeutic effectiveness of acetylsalicylic acid
When bufexamac is used together with sulfasalazine, this leads to a reduction in therapeutic effectiveness of sulfasalazine
When bufexamac is used together with diflunisal, this leads to a reduction in therapeutic effectiveness of diflunisal
When bufexamac is used together with choline salicylate, this leads to a reduction in therapeutic effectiveness of choline salicylate
When bufexamac is used together with balsalazide, this leads to a reduction in therapeutic effectiveness of balsalazide
When bufexamac is used together with bismuth subsalicylate, this leads to a reduction in therapeutic effectiveness of bismuth subsalicylate
When bufexamac is used together with aminosalicylic acid, this leads to a reduction in therapeutic effectiveness of aminosalicylic acid
When bufexamac is used together with protriptyline, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with dosulepin, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with butriptyline, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with trimipramine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with imipramine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with doxepin, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with amoxapine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with nortriptyline, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with dibenzepin, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with clomipramine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When bufexamac is used together with desipramine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When benorilate is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When benoxaprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When benzydamine is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When betulinic acid is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When bromfenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When bumadizone is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When carprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When celecoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
choline magnesium trisalicylateÂ
When choline magnesium trisalicylate is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When dexibuprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When dexketoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When diclofenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When etodolac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When etoricoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When fenbufen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When fenoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When floctafenine is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When flurbiprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When glycol salicylate is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When ibuprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When icosapent is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When indomethacin is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When ketoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When ketorolac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When lornoxicam is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When loxoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When lumiracoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When meclofenamic acid is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When oxaprozin is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When oxyphenbutazone is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When parecoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When phenylbutazone is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When piroxicam is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When mefenamic acid is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When meloxicam is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When menthyl salicylate is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When nabumetone is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When naproxen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When nepafenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When nimesulide is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When rofecoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When salicylamide is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When salicylic acid is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When salsalate is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When sulindac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When suprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When tenoxicam is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When tiaprofenic acid is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When tolfenamic acid is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When tolmetin is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When valdecoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
Action:
Anti-Inflammatory Action:
Bufexamac’s anti-inflammatory activity is due to its ability to reduce the production of the mediators involved in inflammation like prostaglandins.
It is a Cyclooxygenase (COX) inhibitor that suppresses the prostaglandins formed from arachidonic acid.
Analgesic (Pain-Relieving) Action:
It works by inhibiting the synthesis of prostaglandins hence lowering inflammation and the pain that are associated with the condition.
It is used in conditions like arthritis, dermatitis as well as many other inflammatory skin diseases.
Spectrum:
Bufexamac belongs to the NSAIDs group, usually used in dermatological practice in the management of several inflammatory dermatoses.
Thus, it may be useful in conditions like contact dermatitis, eczema, and other forms of inflammatory dermatoses with pruritis.
Frequency not defined
Hypersensitivity reactions
None
Contraindication/Caution:
Hypersensitivity or Allergy
Skin Infections
Open Wounds or Lesions
Pregnancy and Lactation
Children
Renal or Hepatic Impairment
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:Â Â Â Â Â Â Â
Pharmacology: Bufexamac belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs) that have earlier been used topically as the local analgesic and anti-inflammatory agents.
Pharmacodynamics: Bufexamac functions by the inhibition of the cyclooxygenase (COX) enzyme, which plays a vital role in the conversion of arachidonic acid into prostaglandins. Inhibiting prostaglandins reduces inflammation, discomfort, and swelling. The main mechanism of action of bufexamac is inhibition of COX-2, an inflammatory enzyme.
Pharmacokinetics:
Absorption
Bufexamac is primarily administered topically and applied directly to the skin.
It is absorbed through the skin and can penetrate the underlying tissues.
Distribution
Once absorbed, bufexamac is distributed within the local tissues, exerting its anti-inflammatory effects.
Metabolism
Bufexamac undergoes metabolism, primarily in the liver.
The specific metabolic pathways and the identity of metabolites may vary.
Excretion and Elimination
Metabolites of bufexamac and any unmetabolized drug are likely eliminated through renal and/or fecal routes.
The elimination half-life and clearance of bufexamac can vary among individuals.
Administration:
The administration of bufexamac, when it was available, typically involved applying a thin layer of the cream to the areas of affected skin.
Patient information leaflet
Generic Name: bufexamac
Why do we use bufexamac?
Bufexamac is given in conditions like inflammation, itching, and erythema that results from dermatitis and eczema and it has been found to reduce the inflammation that is associated with these skin diseases, thereby reliving the symptoms.
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