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Brand Name :
Quviviq
Synonyms :
daridorexant
Class :
Orexin Antagonists; Sedative/Hypnotics
Brand Name :
Quviviq
Synonyms :
daridorexant
Class :
Orexin Antagonists; Sedative/Hypnotics
Dosage forms & Strengths:
Adult:
Schedule IV Tablet
25 mg
50 mg
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased Effect of a CNS depressant when combined with blonanserin
may have an increased Effect of a CNS depressant when combined with blonanserin
may have an increased Effect of a CNS depressant when combined with blonanserin
may enhance the concentration of serum when combined with daridorexant
may enhance the concentration of serum when combined with daridorexant
may enhance the concentration of serum when combined with daridorexant
may enhance the concentration of serum when combined with daridorexant
may enhance the concentration of serum when combined with daridorexant
daridorexant: they may enhance the serum concentration of CYP3A Inhibitors
daridorexant: they may enhance the serum concentration of CYP3A Inhibitors
daridorexant: they may enhance the serum concentration of CYP3A Inhibitors
daridorexant: they may enhance the serum concentration of CYP3A Inhibitors
daridorexant: they may enhance the serum concentration of CYP3A Inhibitors
may increase the CNS depressant effect
hydrocodone/chlorpheniramine/pseudoephedrine
may increase the CNS depressant activity of CNS depressants
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effects of CNS depressants
may increase the CNS depressants effects of CNS depressants
acrivastine and pseudoephedrine
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
buprenorphine,long-acting injection
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
daridorexant: they may diminish the serum concentration of CYP3A4 Inducers
daridorexant: they may diminish the serum concentration of CYP3A4 Inducers
daridorexant: they may diminish the serum concentration of CYP3A4 Inducers
daridorexant: they may diminish the serum concentration of CYP3A4 Inducers
daridorexant: they may diminish the serum concentration of CYP3A4 Inducers
nafcillin will decrease the effect of action of daridorexant by affecting enzyme CYP3A4 metabolism.
the effect of daridorexant is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of daridorexant
CYP3A4 inducers decrease the concentration of daridorexant in serum
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
mephenesin and daridorexant, when used together, the risk or seriousness of CNS depression may rise
The potential for increased CNS depression risk or seriousness occurs when daridorexant is used together with pipecuronium
When daridorexant is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When chlordiazepoxide is used together with daridorexant, this leads to enhanced risk or seriousness of CNS depression
When daridorexant is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with daridorexant, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with daridorexant, this leads to enhanced risk or seriousness of CNS depression
may increase the CNS depressant effect
may increase the CNS depressant effect of CNS depressants
It may enhance the risk of adverse effects when combined with Hypnotics
pneumococcal vaccine 13-valent
It may enhance the risk of adverse effects when combined with Hypnotics
pneumococcal vaccine heptavalent
It may enhance the risk of adverse effects when combined with Hypnotics
pneumococcal vaccine polyvalent
It may enhance the risk of adverse effects when combined with Hypnotics
cinnarizine and dimenhydrinate
this combination will make you feel sleepy or tired when Tranquillisers used in combination
When used with sedatives, eschscholzia californica can show addictive properties
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
Actions and Spectrum:
daridorexant blocks neuropeptides from binding to OX1R & OX2R, thereby suppressing wake drive.
Black Box Warning:
It is essential to follow the dosage and administration instructions for the medication carefully.
Contraindication/Caution:
daridorexant should not be used in people hypersensitive to the drug itself.
Pregnancy consideration:
No data is available regarding the usage of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the secretion of the drug in breast milk.
Pregnancy category:
Pharmacology
Pharmacodynamics: Not available
Pharmacokinetics:
Pharmacokinetics is the study of how a drug is absorbed, distributed, metabolized, and eliminated by the body. The pharmacokinetics of daridorexant can be described by the following parameters:
Absorption
Peak plasma concentration is achieved in 1-2 hour
The drug is 62% bioavailable
Distribution
The volume of distribution is 31L
99.7% is the bound protein.
Metabolism
Metabolized by CYP3A4 inducers
Elimination and excretion
The half-life of the drug is 8 hours
The drug is excreted in feces and urine
Administration:
Take the dose orally within 30 minutes prior to going to bed. Do not take it with food.
Patient information leaflet
Generic Name: daridorexant
Pronounced: dar-ido-reks-ant
Why do we use daridorexant?
daridorexant is used to treat insomnia.
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