Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Duphaston, Nidaston, Dydrop, Jigest
Synonyms :
Didrogesterone, didrogesterona, hydrogesterone,
Class :
Glucocorticoids, Progestogens
Brand Name :
Duphaston, Nidaston, Dydrop, Jigest
Synonyms :
Didrogesterone, didrogesterona, hydrogesterone,
Class :
Glucocorticoids, Progestogens
Dosage Forms & Strengths
Vaginal tablets/ Suppositories/ Tablet
10mg
10
mg
Tablet
Orally
twice a day
10mg orally twice daily up to the 12th or 20th week of pregnancy
10 - 30
mg
Orally
once a day
10-30mg orally once daily from the 5th to the 25th day of the cycle
10 - 30
mg
Orally
once a day
10-30mg orally once daily from the 5th to the 25th day of the cycle
10 - 30
mg
Orally
once a day
10-30mg orally once daily from the 5th to the 25th day of the cycle
10mg orally once daily from the 14th to the 25th day of the cycle for six months
10mg or 20mg orally once daily should be taken during 2nd half of the menstrual phase until 1st day of the next cycle
Indications: it is indicated to treat infertility due to luteal insufficiency
Continuous sequential therapy (in combination with treatment of estrogen continuously):
10mg orally once daily for two weeks of a 28-day cycle. The dose can be adjusted to 20mg based on the clinical response
Cyclic treatment (in combination with estrogen therapy in a cyclical manner):
10mg orally once daily for the last 12-14 days of treatment with estrogen. The dose can be adjusted to 20mg based on the clinical response
10mg orally twice daily from 11th to 15th day of cycle. Consecutively 10mg twice daily starting on 2nd half of the menstrual phase until 1st day of the next menstrual cycle.
To control excessive bleeding
10mg orally twice daily for 5- 7 days. Consecutively, 20mg to 30mg daily for up to 10 days.
For continued prevention
10mg or 20mg orally once daily from the 11th to 25th days of the cycle.
10mg to 20mg orally once daily from the 5th to 25th day of the menstrual phase
In combination with estrogen to prime endometrium
10mg or 20mg orally once daily from the 11th to the 25th day of menstrual cycle
Indications: It is indicated in treating secondary amenorrhea
Continuous sequential therapy (in combination with treatment of estrogen continuously):
10mg orally once daily for 2 weeks of a 28-day cycle. Dose can be adjusted to 20mg based on the clinical response.
Cyclic treatment (in combination with estrogen therapy in a cyclical manner):
10mg orally once daily for the last 12-14 days of treatment with estrogen. The dose can be adjusted to 20mg based on the clinical response
Indications: it is indicated in the prophylaxis of postmenopausal osteoporosis
Dosage Forms & Strengths
Data not available
Refer to adult dosing
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
etonogestrel/ethinyl estradiol
may diminish the serum concentration of each other when combined
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
may diminish the concentration of serum when combined with hormonal contraceptives
asunaprevir: they may diminish the serum concentration of hormonal contraceptives
efavirenz: they may diminish the serum concentration of hormonal contraceptives
fosaprepitant: they may diminish the serum concentration of hormonal contraceptives
ixazomib: they may diminish the serum concentration of hormonal contraceptives
topiramate: they may diminish the serum concentration of hormonal contraceptives
anastrozole: they may diminish the serum concentration of hormonal contraceptives
may diminish the serum concentration when combined with hormonal contraceptives
may diminish the serum concentration when combined with hormonal contraceptives
CYP3A strong enhancers of the small intestine may reduce the bioavailability of dydrogesterone
ulipristal: they may decrease the therapeutic effect of progestins
Could potentially reduce the concentration serum of hormonal contraceptives
Could potentially reduce the concentration serum of hormonal contraceptives
Could potentially reduce the concentration serum of hormonal contraceptives
Hormonal Contraceptives increase the effect of thrombogenesis of tranexamic acid
may enhance the serum concentration when combined with hormonal contraceptives
may enhance the serum concentration when combined with hormonal contraceptives
may enhance the serum concentration when combined with hormonal contraceptives
may enhance the serum concentration when combined with hormonal contraceptives
may enhance the serum concentration when combined with hormonal contraceptives
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
retinoic acid derivatives decrease the efficacy of progestins
When dydrogesterone is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
the serum levels of dydrogesterone may be increased
the anticoagulant activity of abciximab may be reduced
the anticoagulant activity of acenocoumarol may be reduced
the anticoagulant activity of alteplase may be reduced
the rate of metabolism of dydrogesterone may be reduced
the rate of metabolism of dydrogesterone may be reduced
the serum levels of avanafil may be increased
the rate of metabolism of dydrogesterone may be reduced
the anticoagulant activity of betrixaban may be reduced
the rate of metabolism of dydrogesterone may be reduced
the rate of metabolism of dydrogesterone may be reduced
the anticoagulant activity of dabigatran may be reduced
the rate of metabolism of dydrogesterone may be reduced
the anticoagulant activity of defibrotide may be reduced
the anticoagulant activity of desirudin may be reduced
the anticoagulant activity of dextran may be reduced
the rate of metabolism of dydrogesterone may be reduced
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
an increase in rate of metabolism may be seen
progestins could potentially intensify the Harmful/toxic effects of chlorprothixene
could potentially lead to a reduction in the concentration serum of Hormonal Contraceptives
The concentration serum of flibanserin may be intensified by hormonal contraceptive
The thrombogenic effect of carfilzomib might be intensified using hormonal contraceptives
Could potentially lead to a reduction in the concentration serum of hormonal contraceptives
Actions and spectrum:
Progesterone is a hormone that does important things in the uterus. It attaches to special spots called receptors inside the uterus. When progesterone connects to these receptors, it helps the lining of the uterus grow thick and healthy. This is important for keeping things regular every month.
Progesterone also makes sure the uterine lining sheds properly during a woman’s period. Without progesterone doing its job properly, women might have trouble getting pregnant or have other reproductive health issues.
Frequency not defined
Nausea
Headache
Tenderness in breast
Menstrual disorders
Pain in breast
Dizziness
Weight gain
Stomach pain
Vomiting
Black Box Warning
Heart problems have a higher chance of occurring. There’s an elevated risk of issues with blood flow and the heart itself. These include high blood pressure, heart attacks, strokes and related conditions. Different things cause higher risk. Lifestyle choices matter.
Health problems already present also play a role. So do genes and medications. It’s crucial to pay attention and manage risks. Change habits and monitor health regularly. Follow doctor’s advice precisely for treatment.
Contraindication/Caution:
Contraindication:
Hypersensitivity
Venous thromboembolism
Hepatic impairment
Herpes gestationis
Depression
Pregnancy consideration:
USFDA pregnancy category: Not recommended
The drug is safe to use until the 12th week of pregnancy
Lactation:
Data about the excretion of drugs into human milk is not known
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Dydrogesterone mimics progesterone, a natural female hormone. It’s made artificially, but works like real progesterone. Dydrogesterone is taken by mouth as a pill. This allows it to have effects throughout the body. Structurally, dydrogesterone closely resembles progesterone. That’s why it’s well-tolerated and effective medicinally. Doctors prescribe it to treat menstrual irregularities, aid hormone replacement, and assist fertility procedures. Its main role is maintaining a proper hormonal balance for female reproductive health.
Pharmacodynamics:
Dydrogesterone imitates progesterone’s effects. It helps get the uterus ready for a fertilized egg to implant. This medicine also helps pregnancies continue normally. Dydrogesterone regulates periods and menstrual cycles too. It works similarly to progesterone in multiple ways.
Pharmacokinetics:
Absorption
Dydrogesterone is rapidly absorbed in the GI tract with 28% bioavailability.
Distribution
A significant portion, exceeding 90%, of the drug molecules bind to proteins within the body. This crucial interaction substantially impacts the drug’s availability and efficacy.
Metabolism
Metabolism happens in the liver. This leads to DHD forming. This is the main byproduct of dydrogesterone. DHD stands for 20-dihydrodydrogesterone.
Elimination and excretion
Most of this drug is excreted via urine, around sixty-three percent. Its elimination rate differs between itself and its byproduct, DHD. The medicine’s half-life spans from five to seven hours. However, its metabolite has a longer half-life, ranging fourteen to seventeen hours.
Administration:
Dydrogesterone should be taken orally with or without meals.
Patient information leaflet
Generic Name: dydrogesterone
Why do we use dydrogesterone?
Dydrogesterone treats several gynecological conditions. It helps manage premenstrual syndrome, painful periods, irregular menstrual cycles, and abnormal uterine bleeding. Additionally, postmenopausal women receive dydrogesterone for hormone replacement therapy.
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