Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Halotestin, Androxy
Synonyms :
fluoxymesterone
Class :
Androgens and Anabolic steroids
Brand Name :
Halotestin, Androxy
Synonyms :
fluoxymesterone
Class :
Androgens and Anabolic steroids
Dosage forms & StrengthsÂ
Schedule III TabletÂ
2mgÂ
5mgÂ
10mgÂ
5-20 mg tablet orally once daily used to supplement the body's natural production of testosterone in males
In females as palliative adjunctive therapy, 10-40 mg/day orally divided for 3 months or more
Off-label
It can be used in prophylaxis of angioneurotic edema and post-partum breast engorgement
Dosage forms & StrengthsÂ
Schedule III TabletÂ
2mgÂ
5mgÂ
10mgÂ
5-20 mg orally each day
In children, androgens should be used cautiously
Healthcare specialists should only provide the medication, who are well-versed in the adverse effects of bone maturation
Refer to the adult dosingÂ
may increase the hypoglycemic effect of blood glucose-lowering agents
may increase the hepatotoxic effect of cyclosporine
May increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
pexidartinib and fluoxymesterone both increase the effect of each other
pretomanid and fluoxymesterone both increase the toxicity of each other when used simultaneously
fluoxymesterone increases the anticoagulatory effect of warfarinÂ
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the hypoglycemic effect
they increase the effect of androgens
androgens: they may increase the hypoglycemic effect of blood viscosity reducing agents
androgens: they may increase the hypoglycemic effect of blood viscosity reducing agents
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypertensive effect of hypertension-associated agents
may increase the hypertensive effects of hypertension associated agents
may increase the fluid-retaining effect of corticosteroids
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may increase the hypertensive effect of Hypertension-Associated Agents
It may increase the thrombogenic effect when combined with C1 inhibitors
empagliflozin and linagliptinÂ
may increase the hypoglycaemic effect with blood glucose lowering agents
may increase the hypoglycemic effect of Antidiabetic Agents
may increase the Glucose-lowering effect of Agents with Blood Glucose Lowering Effects
androgens increase the effect of hypoglycemia in these agents
androgens increase the effect of hypoglycemia in these agents
androgens increase the effect of hypoglycemia in these agents
androgens increase the toxic or adverse effect of ajmaline
antithymocyte globulin equineÂ
may increase the hypertensive effect of hypertension-associated agents
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
androgens increase the effect of thrombogenesis of C1 inhibitors
may have an increased hypertensive effect when combined with androgens
may have an increased hypokalemic effect when combined with amphotericin b
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
Actions and Spectrum:Â
fluoxymesterone has a range of actions on the body, including:Â
The spectrum of fluoxymesterone includes its use in the treatment of:Â
Frequency definedÂ
>10%Â
EdemaÂ
AcneÂ
Breast sorenessÂ
PriapismÂ
Menstrual irregularitiesÂ
VirilizationÂ
Frequency not definedÂ
GynecomastiaÂ
AnaphylaxisÂ
None
Contraindication/Caution:Â
fluoxymesterone is a medication that should only be taken under the guidance of a healthcare professional and with careful consideration of its contraindications and precautions. Some of the contraindications and precautions of fluoxymesterone include:Â
Pregnancy consideration:Â Â
Category XÂ
Breastfeeding warnings:Â Â
Excretion of fluoxymesterone in breastmilk is unknown; hence contraindicatedÂ
Pregnancy category:Â
Pharmacology:Â
fluoxymesterone is a synthetic androgen that belongs to the class of anabolic steroids. It has both anabolic and androgenic effects and is used mainly to treat conditions that result in a low level of testosterone, such as delayed puberty and hypogonadism.Â
fluoxymesterone works by binding to and activating the androgen receptor, which leads to an increase in protein synthesis and an increase in nitrogen retention in the muscles. This results in an increase in muscle mass and strength.Â
In addition to its anabolic effects, fluoxymesterone also has androgenic effects. These include the growth of facial and body hair, deepening of the voice, and an increase in sebum production, which can lead to acne.Â
fluoxymesterone is available as an oral tablet, and its effects can be felt within a few hours of administration. The half-life of fluoxymesterone is approximately 9 hours, and it is metabolized in the liver.Â
Like other anabolic steroids, fluoxymesterone can cause several side effects, particularly when used in high doses or for prolonged periods. These can include liver toxicity, cardiovascular disease, high blood pressure, decreased fertility, and mood changes.Â
Pharmacodynamics:Â
The pharmacodynamics of fluoxymesterone involve its effects on the androgen receptor and the subsequent changes in protein synthesis, nitrogen retention, and other physiological processes.Â
fluoxymesterone is a synthetic androgen that binds to and activates the androgen receptor. Once bound, the activated receptor complex moves to the cell nucleus, where it binds to and regulates the transcription of specific genes. This leads to an increase in protein synthesis, which is necessary for muscle growth and repair.Â
fluoxymesterone also increases nitrogen retention in the muscles, which is important for muscle growth. By retaining more nitrogen, the body can maintain a positive nitrogen balance, which promotes muscle growth.Â
In addition to its anabolic effects, fluoxymesterone also has androgenic effects, which are mediated by its binding to the androgen receptor. These effects include the growth of facial and body hair, deepening of the voice, and an increase in sebum production.Â
fluoxymesterone is metabolized in the liver and excreted in the urine. Its effects can be felt within a few hours of administration, and it has a half-life of approximately 9 hours.Â
Pharmacokinetics:Â
AbsorptionÂ
fluoxymesterone is rapidly absorbed after oral administration, with peak blood levels occurring within 1-2 hours. It has high bioavailability, estimated to be approximately 80%, and can be taken with or without food.Â
DistributionÂ
fluoxymesterone is highly bound to plasma proteins, particularly sex hormone-binding globulin (SHBG) and albumin. It has a large volume of distribution, estimated to be about 200 L, and can cross the blood-brain barrier.Â
MetabolismÂ
fluoxymesterone undergoes extensive hepatic metabolism, primarily by hydroxylation and conjugation. The major metabolite is 6-beta-hydroxyfluoxymesterone, which has weaker androgenic activity than the parent compound. The half-life of fluoxymesterone is approximately 9.2 hours, while the half-life of the metabolite is longer, around 13.1 hours.Â
Elimination and Excretion Â
fluoxymesterone and its metabolites are excreted in the urine, primarily as glucuronide and sulfate conjugates. Less than 10% of the administered dose is excreted unchanged in the urine.Â
Administration:Â
fluoxymesterone is typically administered orally in tablet form. The recommended dosage and duration of treatment depend on the condition being treated, the patient’s age and sex, and other factors.Â
To treat hypogonadism or delayed puberty in males, the usual starting dose of fluoxymesterone is 5-20 mg daily, which may be increased gradually to a maximum of 40 mg daily. Depending on the patient’s response, treatment may be continued for several months or longer.Â
For treating metastatic breast cancer in postmenopausal women, the usual dose of fluoxymesterone is 10-40 mg per day, divided into two or three doses. Depending on the patient’s response, treatment may be continued for several months or longer.Â
For treating androgen-responsive cancers such as prostate cancer, the usual dose of fluoxymesterone is 10-40 mg per day, divided into two or three doses. Depending on the patient’s response, treatment may be continued for several months or longer.Â
fluoxymesterone should be taken with food to minimize stomach upset. It should also be taken at the same time(s) each day to maintain a consistent blood level of the medication.Â
Patient information leafletÂ
Generic Name: fluoxymesteroneÂ
Pronounced: flu-oxy-mes-ter-oneÂ
Why do we use fluoxymesterone?Â
fluoxymesterone is a synthetic androgen that is used for a variety of purposes, including:Â
It can treat hypogonadism, a condition in which the body does not produce enough testosterone. It can help increase muscle mass, bone density, and libido in men with this condition.Â
fluoxymesterone can also treat delayed puberty in boys, helping to promote the development of secondary sexual characteristics such as facial hair, voice deepening, and muscle growth.Â
It can be used to treat metastatic breast cancer in women who have gone through menopause. It can help slow the cancer cells’ growth by blocking the breast tissue’s estrogen receptors.Â
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