Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Fycompa
Synonyms :
perampanel
Class :
Anticonvulsants; Antiepileptic agents, AMPA Glutamate Antagonists
Brand Name :
Fycompa
Synonyms :
perampanel
Class :
Anticonvulsants; Antiepileptic agents, AMPA Glutamate Antagonists
Dosage forms & Strengths
Tablet
2 mg
4 mg
6mg
8 mg
10 mg
12 mg
Oral suspension
0.5 mg/ ml
Initial dose:
2mg orally at bedtime; may be increased by 2 mg once a week
Maintenance dose:
8-12 mg daily; some may respond with 4mg
Do not exceed 12 mg daily
Initial dose:
2mg orally at bedtime; may be increased by 2 mg once a week
Maintenance dose:
8 mg daily; some may respond with 12mg
Do not exceed 12 mg daily
Dosage forms & Strength
Tablet
2 mgÂ
4 mgÂ
6mgÂ
8 mgÂ
10 mgÂ
12 mgÂ
Oral suspension
0.5 mg/ mlÂ
Age: >4 years
Initial dose:
2mg orally at bedtime; may be increased by 2 mg once a week
Maintenance dose:
8-12 mg daily; some may respond with 4mg
Do not exceed 12 mg daily
Age: >12 years
Initial dose:
2mg orally at bedtime; may be increased by 2 mg once a week
Maintenance dose:
8 mg daily; some may respond with 12mg
Do not exceed 12 mg daily
Refer adult dosing
perampanel: they may diminish the serum concentration of CYP3A4 Inducers
perampanel: they may diminish the serum concentration of CYP3A4 Inducers
perampanel: they may diminish the serum concentration of CYP3A4 Inducers
perampanel: they may diminish the serum concentration of CYP3A4 Inducers
perampanel: they may diminish the serum concentration of CYP3A4 Inducers
may decrease the diagnostic effect when combined with metyrapone
may have an increased arrhythmogenic effect when combined with lamotrigine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the effect of flunarizine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the CNS suppression effect of thalidomide
CYP3A strong enhancers of the small intestine may reduce the bioavailability of perampanel 
perampanel may enhance the CNS depressant effect of CNS Depressants
perampanel may enhance the CNS depressant effect of CNS Depressants
perampanel may enhance the CNS depressant effect of CNS Depressants
perampanel may enhance the CNS depressant effect of CNS Depressants
perampanel may enhance the CNS depressant effect of CNS Depressants
CNS depressants increase the CNS depressing effect of brexanolone
it increases the effect of CNS depressants
hyponatremic agents increase the effect of desmopressin
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the effect of sedation of metyrosine
it decreases the concentration of anti-seizure agents in serum
CNS depressants increase the effect of sedation of ropinirole
CNS depressants increase the effect of sedation of rotigotine
it increases the toxicity of CNS depressants
it increases the CNS depressing activity of perampanel
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may enhance the adverse/toxic effect of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may increase the risk of adverse effects of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the risk of adverse/toxic effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
may enhance the adverse effect of antipsychotic agents
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may enhance the serum concentration of CYP2D6 Inhibitors
perampanel: they may enhance the serum concentration of CYP2D6 Inhibitors
perampanel: they may enhance the serum concentration of CYP2D6 Inhibitors
perampanel: they may enhance the serum concentration of CYP2D6 Inhibitors
perampanel: they may enhance the serum concentration of CYP2D6 Inhibitors
the effect of perampanel is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
it increases the effect of CNS depressants
it increases the effect of CNS depressants
when combined, it may increase sedation
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
acetaminophen/doxylamine/dextromethorphanÂ
may enhance the metabolism when combined
seizure lowering agents increase the toxic or adverse effects of other antipsychotic agents
seizure lowering agents increase the toxic or adverse effects of other antipsychotic agents
seizure lowering agents increase the toxic or adverse effects of other antipsychotic agents
seizure lowering agents increase the toxic or adverse effects of other antipsychotic agents
seizure lowering agents increase the toxic or adverse effects of other antipsychotic agents
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the effect of flunitrazepam
perampanel decreases the concentration of hormonal contraceptives in the serum
perampanel decreases the concentration of hormonal contraceptives in the serum
perampanel decreases the concentration of hormonal contraceptives in the serum
perampanel decreases the concentration of hormonal contraceptives in the serum
it increases the effect of CNS depressants
it decreases the effect of anti-seizure agents
anti-seizure agents decrease the effect of metyrapone
it decreases the concentration of perampanel in the serum
it decreases the effect of anti-seizure agents
seizure lowering agents increase the toxic or adverse effects of iopamidol
Actions and Spectrum:
action of perampanel is not fully understood. However, it is thought to work by blocking the activity of AMPA receptors, which are glutamate receptors in the brain that play a role in the initiation and spread of seizures. By blocking these receptors, perampanel is believed to reduce the excessive neuronal excitability associated with seizures.
As for the spectrum of perampanel, it is primarily indicated for the treatment of partial-onset seizures with or without secondary generalized seizures in patients with epilepsy.
Frequency defined
10%
Dizziness Â
Somnolence Â
HeadacheÂ
Fatigue Â
IrritabilityÂ
1-10%:Â
Falls Â
Nausea Â
Ataxia Â
Vertigo Â
Balance disorder Â
Back pain Â
Weight gain Â
Vomiting Â
Anxiety Â
Blurred vision Â
Dysarthria Â
Cough Â
Hypoaesthesia Â
Constipation Â
ArthralgiaÂ
Extremity pain Â
Aggression Â
Anger Â
Myalgia Â
Diplopia Â
Injuries due to falls Â
Hypersomnia Â
Hyponatremia Â
Contusions Â
Oropharyngeal pain Â
Asthenia Â
Confusional state Â
Euphoric mood Â
Altered mood Â
Abnormal coordination Â
Musculoskeletal pain Â
Peripheral edema Â
Memory impairment Â
Paraesthesia
Black Box Warning:
perampanel may cause serious psychiatric and behavioral reactions, including aggression, hostility, irritability, anger, and suicidal ideation.
Perampanel is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.Â
Pregnancy consideration:Â Â
Pregnancy Category: N/A
Breastfeeding warnings:Â Â
Take the drug with caution during breastfeeding.Â
Pregnancy category:Â
Administration:
perampanel is available in tablet form, and it is typically taken orally once daily. The tablets should be swallowed whole with water and can be taken with or without food. It is important to follow the instructions provided by your healthcare provider or the medication’s label regarding the dosage and timing of administration.
Patient information leafletÂ
Generic Name:Â perampanel
Pronounced: per-am-pa-nel
Why do we use perampanel?Â
perampanel is a medication that belongs to a class of drugs known as antiepileptic or anticonvulsant agents. It is primarily used for the treatment of epilepsy, specifically as an adjunctive (add-on) therapy for partial-onset seizures with or without secondary generalized seizures in patients who are 12 years of age and older.
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