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Brand Name :
Triptodur
(United States) [Available] ,Trelstar Mixject
(United States) [Available]Synonyms :
Triptorelin
Class :
Class: Antineoplastics and Sub class: GnRH Agonist   
Brand Name :
Triptodur
(United States) [Available] ,Trelstar Mixject
(United States) [Available]Synonyms :
Triptorelin
Class :
Class: Antineoplastics and Sub class: GnRH Agonist   
Dosage Forms & Strengths:  Â
lyophilized powder for reconstitution Â
Reconstitution results in suspension for IM injection  Â
3.75 mg per vial  Â
11.25 mg per vial  Â
22.5 mg per vial  
3.75
mg
Intramuscular (IM)
4
weeks
or 11.25 mg shown IM for every 12 weeks, or 22.5 mg given IM for every 24 weeks
Dose Adjustments
Renal Dose Adjustments:
There is no adjustment recommended
Liver Dose Adjustments:
There is no adjustment recommended
Dosage Forms & Strengths: Â
lyophilized powder for reconstitution   Â
22.5mg/vial; reconstitution results in suspension for IM injection  Â
The kit is for single use and contains a drug vial, prefilled diluent syringe, and 21-gauge needle  
The dose recommended for >2years is 22.5 mg given IM every 24 weeks
Dose Adjustments
Renal Dose Adjustments:
There is no adjustment recommended
Liver Dose Adjustments:
There is no adjustment recommended
CYP3A Inhibitors: they may diminish the serum concentration of hormonal agents
CYP3A Inhibitors: they may diminish the serum concentration of hormonal agents
CYP3A Inhibitors: they may diminish the serum concentration of hormonal agents
CYP3A Inhibitors: they may diminish the serum concentration of hormonal agents
CYP3A Inhibitors: they may diminish the serum concentration of hormonal agents
when both drugs are combined, there may be an increased risk or severity of QTC prolongation   
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be a decreased therapeutic efficacy of mifepristone   
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
indium In-111 capromab pendetideÂ
may decrease the diagnostic effect when combined
indium In-111 capromab pendetideÂ
may decrease the diagnostic effect when combined
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be a decreased therapeutic efficacy of albiglutide  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be a decreased therapeutic efficacy of alogliptin  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation  
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
it may enhance the risk of QTc prolongation when combined with amifampridine
when both drugs are combined, there may be a decreased therapeutic efficacy of sulfamethoxazole  
Triptorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH) that acts as an agonist. In animal studies, it demonstrated significantly greater potency than natural GnRH, showing a 13-fold increase in luteinizing hormone release and a 21-fold increase in follicle-stimulating hormone release.Â
Adverse drug reactions:  Â
Frequency defined  Â
1-10%  Â
Cough  Â
Diarrhea  Â
Fatigue  Â
Generalized pain  Â
Headache   Â
Hot flushes  Â
Hypertension   Â
Impotence  Â
Injection site pain  Â
Injection site pruritus   Â
Injection site swelling  Â
Insomnia  Â
Pruritus   Â
Spinal cord compression  Â
UTI   Â
Upper respiratory infection   Â
Vaginal bleeding   Â
Vomiting  Â
>10%  Â
Headache  Â
Hot flushes   Â
Injection site pain   Â
Injection site redness  Â
Nasopharyngitis  Â
Skeletal pain
Tumor flare in prostate cancer patients (initial worsening of symptoms due to transient hormone surge).Â
Hyperglycemia and diabetes risk.Â
Cardiovascular risks, including increased risk of heart attack, sudden cardiac death, and stroke.Â
Psychiatric effects, such as mood swings and depression.Â
Decreased bone mineral density with long-term use.Â
ContraindicationsÂ
Known hypersensitivity to triptorelin or GnRH analogues.Â
Pregnancy and breastfeeding.Â
CautionsÂ
May cause osteoporosis with long-term use due to hypoestrogenism/hypogonadism.Â
Monitor bone density in prolonged therapy.Â
Use with caution in patients with cardiovascular disease, diabetes, or seizure disorders.Â
May cause menopausal symptoms (hot flashes, mood changes).Â
Patients should be monitored for psychological effects such as depression.Â
Pregnancy warnings:  Â
Breastfeeding warnings:  Â
 Pregnancy Categories:     Â
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) agonist. Its pharmacological action involves an initial stimulation of the pituitary gland, leading to a transient surge in the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This results in a temporary increase in sex hormones—testosterone in males and estrogen in females. However, with continued administration, triptorelin causes downregulation of GnRH receptors in the pituitary, suppressing LH and FSH secretion. Consequently, this leads to a significant reduction in circulating testosterone and estrogen levels. This hormonal suppression is therapeutically beneficial in hormone-dependent conditions such as prostate cancer, breast cancer, and central precocious puberty, where lowering sex hormone levels helps inhibit disease progression.Â
Intramuscular (IM) or subcutaneous (SC) injectionÂ
It is commonly given as depot injections every 1, 3, or 6 monthsÂ
Generic Name: triptorelinÂ
Pronunciation: TRIP-toe-REL-inÂ
Why do we use triptorelin?Â
Triptorelin is a synthetic hormone used to regulate hormonal activity in the body. Its clinical applications vary by formulation:Â
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