Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
Aceclan,Aceclofar,Aflamil,Bristaflam,Clanza,Zerodol
Synonyms :
aceclofenac
Class :
Analgesic, Nonsteroidal Anti-inflammatory Drug
Brand Name :
Aceclan,Aceclofar,Aflamil,Bristaflam,Clanza,Zerodol
Synonyms :
aceclofenac
Class :
Analgesic, Nonsteroidal Anti-inflammatory Drug
Dosage Forms & StrengthsÂ
Oral TabletÂ
100mg Â
Sustained release tabletÂ
200mgÂ
Safety and efficacy not establishedÂ
Refer adult dosingÂ
may enhance the risk of gastrointestinal irritation when combined with aceclofenac
may increase the risk or severity of hypertension when combined
may diminish the excretion rate of amantadine
may increase the anticoagulation effect when combined
may enhance the risk of adverse effects when combined with aceclofenac
may enhance the risk of hypoglycemia when combined
may increase the risk of adverse effects when combined
aceclofenac decreases efficacy of clonidine when used in combination
the excretion rate of bisoxatin may be decreased with aceclofenac leading to higher concentration in serum
the excretion rate of oxybenzone may be decreased by aceclofenac, leading to increased serum levels of oxybenzone
When suprofen is taken in conjunction with aceclofenac, there is a potential for an enhance in the seriousness of adverse events
it decreases the rate of elimination of pidotimod acemetacin
neuroexcitatory actions of cinoxacin can increase with aceclofenac
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
By competing with acidic (anionic) drugs for renal clearance, aceclofenac will raise the amount of probenecid
The combination of antipyrine with aceclofenac may elevate the seriousness of adverse events
The seriousness of nephrotoxic effect is enhanced when aceclofenac is used in conjunction with cefotiam
it may diminish the excretion rate when combined with gadofosveset, resulting in an enhanced serum level
When aminophenazone is taken together with acelofenac, there is a potential for an elevated risk or enhanced seriousness of adverse events
aceclofenac Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
Combining xamoterol with aceclofenac may elevate the risk/seriousness of hypertension
meticrane has the potential to enhance the rate of excretion of aceclofenac; this can potentially lead to decreased levels of serum, possibly diminishing its effectiveness
levobetaxolol's antihypertensive properties might be reduced by aceclofenac
It may enhance the risk of bleeding when combined with nimesulide
aceclofenac has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
It may enhance the risk of adverse effects when combined with Glycopeptides
It may enhance the risk of adverse effects when combined with Glycopeptides
When loracarbef is used together with acelofenac, the risk or seriousness of nephrotoxicity is enhanced
When acelofenac is used together with hexoprenaline, the potential for hypertension to occur may be elevated
When acelofenac is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When aceclofenac is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with aceclofenac, this leads to enhanced risk or seriousness of adverse outcomes
When aceclofenac is used together with cephaloglycin, this leads to increased risk or seriousness of nephrotoxicity
When melitracen is used together with aceclofenac, this leads to increased risk or seriousness of gastrointestinal bleeding
When aceclofenac is used together with abediterol, this leads to enhanced risk or seriousness of hypertension
When andrographolide is used together with aceclofenac, this leads to enhanced risk or seriousness of bleeding
When aceclofenac is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When aceclofenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
an increase in serum level with a decreased excretion rate of almasilate is observed when used in combination with aceclofenac
ceftizoxime, when used in combination with aceclofenac, there is an increased risk of nephrotoxicity
When aceclofenac is used together with vilanterol, this leads to enhanced risk or seriousness of hypertension
aceclofenac may lower the rate of diatrizoate excretion, thereby raising the serum level
flupirtine excretion rate may be slowed by aceclofenac, raising the possibility of higher serum levels
When aceclofenac is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
aceclofenac leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
When aceclofenac is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
aceclofenac leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
aceclofenac leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
aceclofenac leads to a reduction in the rate of excretion of oxyquinoline, which leads to an increased level of serum
the severity or risk of hypertension can increase when aceclofenac is combined with dihydroergocristine
ioxilan's excretion rate may be reduced by aceclofenac, leading to a higher serum level
aceclofenac leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
the risk of adverse effects could be heightened when aceclofenac is combined with isoxicam
phylloquinone may reduce the excretion rate of abacavir, potentially leading to higher serum levels
the excretion rate of mycophenolic acid may be decreased by aceclofenac, potentially resulting in elevated serum levels
n-acetyl tyrosine excretion rate may be decreased by aceclofenac, potentially resulting in elevated serum levels
sulbactam excretion rate may be decreased by aceclofenac, potentially resulting in elevated serum levels
aceclofenac: it may decrease the excretion rate of iothalamic acid
aceclofenac: it may increase the risk of lidoflazine
aceclofenac: it may decrease the excretion rate of abacavir CNS depressant
aceclofenac: it may decrease the excretion rate of abacavir CNS depressant
aceclofenac: it may decrease the excretion rate of abacavir CNS depressant
aceclofenac: it may decrease the excretion rate of abacavir CNS depressant
aceclofenac: it may decrease the excretion rate of abacavir CNS depressant
When aceclofenac is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
aceclofenac: it may increase the risk or severity of CNS depression
aceclofenac: it may increase the risk or severity of CNS depression
aceclofenac: it may increase the risk or severity of CNS depression
the risk of bleeding can be increased when aceclofenac is combined with sulfinpyrazone
the risk of side effects can be raised when sulindac is used in combination
aceclofenac: it may decrease the antihypertensive activities of oxprenolol
aceclofenac: it may increase the risk of adverse effects of indobufen
aceclofenac and clonixin together may increase the likelihood or extent of side effects
the risk or extent of adverse effects can be increased when aceclofenac is combined with flunixin
the risk or extent of adverse effects can be increased when aceclofenac is combined with tepoxalin
the risk or extent of adverse effects can be increased when niflumic acid is combined with aceclofenac
aceclofenac may heighten the thrombogenic activities of chlorotrianisene
when isometheptene is taken with aceclofenac, the risk or degree of BP may increase
aceclofenac may lower the excretion rate of inosine pranobex, potentially resulting in an increased serum level
aceclofenac may diminish the excretion speed of hydroxyethyl starch, potentially leading to an elevated serum level
choline magnesium trisalicylateÂ
the hazard or intensity of adverse effects can be heightened when Choline magnesium trisalicylate is combined with aceclofenac
the risk or intensity of gastrointestinal bleeding can be heightened when aceclofenac is combined with ibandronate
aceclofenac: it may the therapeutic efficacy of phentolamine
aceclofenac and ginger together enhance anticoagulation
When aceclofenac is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
SSRIs increase the antiplatelet effect of NSAIDs
choline magnesium trisalicylate
may enhance the adverse/toxic effect of salicylates
it may enhance the serum potassium levels
may decrease the levels of serum potassium
it may enhance the serum potassium levels
glycopyrrolate inhaled and formoterolÂ
it enhances the serum potassium levels
may increase the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
anticoagulation is increased by aceclofenac and decreased by mistletoe. The interaction's effect is unclear; exercise caution
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the anticoagulation when combined with ginkgo biloba
may increase the anticoagulation effect when combined
may increase the risk of hypertension when combined
high nephrotoxic reactions occur when cefmetazole interacts with aceclofenac
bacitracin, when combined with aceclofenac, is serious and risky, leading to nephrotoxicity
the excretory rate of ancestim may be reduced with aceclofenac, which results in higher levels in serum
when aceclofenac is combined with fluindione, there is an increased risk of bleeding
an increase in the severity of adverse effects can be seen if aceclofenac is taken with bumadizone
an increase in the severity of adverse effects may be seen when aceclofenac is taken with kebuzone
an increase in the risk of adverse effects can be seen when alclofenac is taken with mofebutazone
the rate of excretion of aurothioglucose may be reduced with aceclofenac
the risk of irritation of the gastrointestinal tract can be seen if fluocortolone is taken with aceclofenac
the likelihood or intensity of adverse effects may increase when aceclofenac is used in combination with alendronic acid
the excretion rate of gadopentetic acid may be reduced by aceclofenac, resulting in a higher serum level
the risk of hypertension may be increased
the hyperkalemic activity of aceclofenac may be increased
the combination of prenylamine with aceclofenac may raise the risk or severity of hyperkalemia
the rate of excretion of topiroxostat may be reduced
the risk of adverse effects may be increased
the risk of adverse effects may be increased
the risk of hypertension may be increased
the risk of hypertension may be increased
the therapeutic activity of Remikiren may be reduced
the risk of adverse effects may be increased
the risk of hypertension, renal failure, and hypokalemia may be increased
the risk of hypertension may be increased
the rate of excretion of phosphoric acid may be decreased
both forskolin and aceclofenac enhance anticoagulation
aceclofenac might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Increased serum concentration level by competitive plasma protein binding.
when both drugs are combined, there may be an increased effect of aceclofenac by acidic (anionic) drug competition for renal tubular clearance 
Actions and Spectrum:Â
The mechanism of action of aceclofenac involves inhibiting the cyclooxygenase (COX) enzyme, which is responsible for the production of prostaglandins. aceclofenac selectively inhibits the COX-2 isoform of the enzyme, which is the primary source of prostaglandins involved in inflammation and pain.
By inhibiting the COX-2 enzyme, aceclofenac reduces the production of prostaglandins, thereby reducing pain and inflammation. aceclofenac has a broad spectrum of activity and is effective in treating various conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other painful inflammatory conditions. It also treats acute pain, including postoperative pain, dental pain, and dysmenorrhea (painful menstrual periods).Â
Frequency not definedÂ
ConstipationÂ
NauseaÂ
Skin rashÂ
Visual DisturbanceÂ
FlushingÂ
Abdominal painÂ
DiarrhoeaÂ
VomitingÂ
DizzinessÂ
FlatulenceÂ
Stomach PainÂ
Contraindications/caution:Â
Contraindications:Â
Caution:Â
Pregnancy consideration: aceclofenac should be avoided during pregnancy as it can harm the developing fetus.Â
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that relieves pain and inflammation. Its pharmacology involves multiple mechanisms of action.Â
Pharmacodynamics:Â
aceclofenac affects various physiological systems, including the musculoskeletal, immune, and nervous systems. In the musculoskeletal system, aceclofenac reduces pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. In the immune system, aceclofenac has anti-inflammatory effects that help reduce the activity of immune cells involved in inflammation. In the nervous system, aceclofenac can reduce pain by inhibiting the activity of specific pain receptors.Â
Pharmacokinetics:Â
AbsorptionÂ
aceclofenac is well absorbed after oral administration, with an absolute bioavailability of about 100%. Food does not affect the rate and extent of absorption, and the drug reaches peak plasma concentration within 1-3 hours.Â
DistributionÂ
aceclofenac is highly protein-bound (more than 99%) to albumin in the plasma. The volume of distribution is relatively small, approximately 25 L, which indicates that the drug does not extensively distribute into the tissues.Â
MetabolismÂ
aceclofenac undergoes extensive metabolism in the liver, converting it into its primary metabolite, diclofenac, by cytochrome P450 enzymes. Diclofenac is also an active anti-inflammatory drug responsible for much of the clinical effects of aceclofenac. aceclofenac is also metabolized to other inactive metabolites, excreted in the urine.Â
Elimination and ExcretionÂ
aceclofenac and its metabolites are excreted mainly in the urine (70-80%) and, to a lesser extent, in the feces. The elimination half-life of aceclofenac is around 4 hours, and it is mainly eliminated in the form of its metabolites.Â
Administration:Â
aceclofenac is usually administered orally in the form of tablets or capsules. The recommended dose of aceclofenac may vary depending on the condition being treated, the severity of the symptoms, and the patient’s age and overall health status. It is essential to follow the dosage instructions the prescribing healthcare provider provides or as directed on the label.Â
The usual adult dose for aceclofenac is 100 mg to 200 mg per day, taken in divided doses. The maximum recommended daily dose is 200 mg. The drug should be taken with food to reduce the risk of gastrointestinal side effects. The tablets should be swallowed whole with water and not crushed or chewed.Â
Patient information leafletÂ
Generic Name: aceclofenacÂ
Why do we use aceclofenac?Â
aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation associated with various conditions such as:Â
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