A Game-Changer for Diabetes: Polymer Delivers Insulin Painlessly Through Skin
November 25, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Asendin
Synonyms :
amoxapinum, desmethylloxapin
Class :
Antidepressants and antianxiety drugs; TCAs
Brand Name :
Asendin
Synonyms :
amoxapinum, desmethylloxapin
Class :
Antidepressants and antianxiety drugs; TCAs
Dosage Forms & StrengthsÂ
TabletÂ
25mgÂ
50mgÂ
100mgÂ
150mgÂ
25 mg orally every 8-12 hours
Increase the dose to 200-300 mg orally every night after 5-7 days
If the dose exceeds more than 300 mg/day, divide the dose every 12 hours
Do not exceed the dose of 400 mg each day
Inpatients may need higher doses; administer up to 600 mg/day as divided doses twice daily
Not recommended for pediatricsÂ
Dosage Forms & StrengthsÂ
TabletÂ
25mgÂ
50mgÂ
100mgÂ
150mgÂ
25 mg orally every 8-12 hours
Increase the dose to 200-300 mg orally every night after 5-7 days
For outpatients, do not exceed the dose of 400 mg each day
For inpatients, a higher dose of 600 mg/day is required, divided twice daily
when both drugs are combined, there may be an increase in qtc interval  Â
QT-prolonging Strong may enhance the QTc-prolonging effect of delamanid
may enhance the QTc-prolonging effect of Fluorouracil Products
may enhance the risk of QTc prolongation when amoxapine is combined
It may enhance QTc interval when combined with pentamidine
may increase the risk of hypertension when combined
it increases the toxicity of norepinephrine reuptake inhibitors
it increases the effect of serotonergic agents
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
anticholinergic agents decrease the efficacy of levosulpride
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
anticholinergic agents increase the ulcer-producing effect of potassium citrate
it increases the effect of Norepinephrine Reuptake Inhibitors
may enhance the QTc-prolonging effect of Nilotinib
glycopyrrolate inhaled and formoterolÂ
may increase the QTc interval when combined
may increase the risk or severity of gastrointestinal bleeding when combined
may have an increased effect of CNS depression when combined with Amoxapine
it may enhance the QTc-prolonging effect of QT-Prolonging Anesthetics
it may enhance the QTc-prolonging effect of QT-Prolonging Anesthetics
it may enhance the QTc-prolonging effect of QT-Prolonging Anesthetics
it may enhance the QTc-prolonging effect of QT-Prolonging Anesthetics
it may enhance the QTc-prolonging effect of QT-Prolonging Anesthetics
CNS depressants increase the CNS depressing effect of brexanolone
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
it increases the effect of CNS depressants
it increases the toxicity of serotonergic agents
it increases the effect of CNS depressants
anticholinergic agents increase the toxicity of topiramate
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
It may reduce the effects when combined with pleurisy root by unspecified interactions mechanism
It may enhance sedation when combined with codeine
it may diminish the therapeutic efficacy when combined with castor oil
It may enhance sedation when combined with oxycodone
it may diminish the metabolism when combined with ciclesonide
The effectiveness of guanoxan's antihypertensive properties could be diminished by the presence of amoxapine
When metixene and amoxapine are combined, the risk or seriousness of adverse events will rise
Combining amoxapine and levobetaxolol may reduce amoxapine’s metabolism
The combination of antipyrine with amoxapine can elevate the risk or seriousness of gastrointestinal bleeding
The potential for increased CNS depression risk or seriousness occurs when amoxapine is used together with pinazepam
When amoxapine is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When captodiame is used together with amoxapine, There is a risk or seriousness of CNS depression is enhanced
When amoxapine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when amoxapine is used together with fencamfamin
When amoxapine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When chlordiazepoxide is used together with amoxapine, this leads to enhanced risk or seriousness of CNS depression
amoxapine: they may enhance the serum concentration of CYP2D6 Inhibitors
amoxapine: they may enhance the serum concentration of CYP2D6 Inhibitors
amoxapine: they may enhance the serum concentration of CYP2D6 Inhibitors
amoxapine: they may enhance the serum concentration of CYP2D6 Inhibitors
amoxapine: they may enhance the serum concentration of CYP2D6 Inhibitors
When amoxapine is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When ponesimod is used together with amoxapine, this leads to enhanced risk or seriousness of bradycardia
When amoxapine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When amoxapine is used together with isoflurophate, this leads to a reduction in the therapeutic effectiveness of amoxapine
When amoxapine is used together with givinostat, this leads to enhanced risk or severity of Qtc prolongation
When emylcamate is used together with amoxapine, this leads to enhanced risk or seriousness of CNS depression
When amoxapine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When bufexamac is used together with amoxapine, this leads to enhanced risk or seriousness of gastrointestinal bleeding
When indisulam is used together with amoxapine, this leads to a reduction in amoxapine metabolism
When amoxapine is used together with flunoxaprofen, this leads to enhanced risk or seriousness of gastrointestinal bleeding
the therapeutic efficacy of amoxapine may be reduced when used in combination with ambenonium
when amoxapine is combined with cimetropium, the chances of adverse effects may be increased
dapoxetine may enhance the intensity of orthostatic hypotensive effects of amoxapine
When amoxapine is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
amoxapine: it may decrease activities of antihypertensive drugs
amoxapine: it may decrease activities of antihypertensive drugs
amoxapine: it may decrease activities of antihypertensive drugs
amoxapine: it may decrease activities of antihypertensive drugs
amoxapine: it may decrease activities of antihypertensive drugs
When amoxapine is used together with diazoxide, this leads to reduction in diazoxide’s antihypertensive effects
when both drugs are combined, both increase the QTC interval  
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
it may enhance the QTc-prolonging effect of levoketoconazole
when combined, it may increase sedation
may increase the QTc interval
when combined, it may increase sedation
QTc-prolongers increase the effect of levoketoconazole
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
may enhance the QTc-prolonging effect of other QT-prolonging Agents
the therapeutic activity of amoxapine may be reduced
the therapeutic activity of amoxapine may be reduced
combining zimelidine with amoxapine may increase the chances of adverse effects
the vasopressor activity of racepinephrine may be increased
the risk of CNS depression may be increased
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
anticholinergic agents increase the effect of constipation of clozapine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of norepinephrine reuptake inhibitors
anticholinergic agents decrease the efficacy of secretin
CNS depressants increase the effect of zolpidem
relugolix/​estradiol/​norethindroneÂ
may increase the effect of each other by an unknown mechanism
Actions and Spectrum:Â
amoxapine is a tricyclic antidepressant (TCA) that blocks the brain’s reuptake of norepinephrine and serotonin. It also has some antipsychotic effects due to its ability to block specific dopamine receptors.Â
The actions of amoxapine include:Â
The spectrum of amoxapine’s side effects includes:Â
Frequency definedÂ
>10%Â
ConstipationÂ
SedationÂ
Dry mouthÂ
1-10%Â
AnxietyÂ
AtaxiaÂ
DizzinessÂ
EdemaÂ
HeadacheÂ
Blurred visionÂ
ConfusionÂ
FatigueÂ
NauseaÂ
RashÂ
SweatingÂ
TremorÂ
NervousnessÂ
Increased prolactin Â
WeaknessÂ
Black Box Warning:Â
amoxapine increases the risk of suicidal thoughts and alters behavior in young adults. The drug is not meant for pediatrics.Â
Contraindication/CautionÂ
amoxapine has several contraindications and cautions, including:Â
Pregnancy consideration:Â Â
Category CÂ
Breastfeeding warnings:Â Â
Use the drug cautiously during lactation, as amoxapine is excreted in breast milk.Â
Pregnancy category:Â
Pharmacology:Â
amoxapine is a tricyclic antidepressant (TCA) with pharmacological actions that include:Â
Pharmacodynamics:Â
The pharmacodynamics of amoxapine involves its interaction with various receptors and enzymes in the brain and peripheral tissues. Some of the critical pharmacodynamic actions of amoxapine include:Â
Pharmacokinetics:Â
The half-life is 8-30 hoursÂ
DistributionÂ
The peak plasma concentration is achieved in 90 minutesÂ
MetabolismÂ
The metabolites formed are 8-hydroxy amoxapineÂ
The volume of distribution is 0.9-1.2 L/kgÂ
Elimination and Excretion Â
Protein-bound is 90%Â
The drug is excreted 60% in urine and 18% in fecesÂ
Administration:Â
amoxapine is typically administered orally in the form of tablets or capsules. The medication is usually taken one to three times daily, with or without food. amoxapine dosage may vary depending on the patient’s age, weight, medical condition, and response to treatment.Â
It is essential to follow the dosing instructions the prescribing healthcare provider provides and stay within the recommended dose. Taking higher doses than prescribed can increase the risk of side effects and toxicity.Â
It is also important to continue taking amoxapine as directed, even if symptoms improve. Abruptly stopping the medication can lead to withdrawal symptoms such as nausea, headache, dizziness, and irritability.Â
amoxapine should be taken at the same time(s) each day to maintain a consistent blood level. If a dose is missed, it should be taken as soon as possible unless it is close to the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule should be resumed.Â
Regular monitoring of therapeutic effectiveness and side effects is necessary during treatment with amoxapine. Reporting any new or worsening symptoms to the prescribing healthcare provider is essential.Â
Patient information leafletÂ
Generic Name:Â amoxapineÂ
Pronounced: amo-xa-pineÂ
Why do we use amoxapine?Â
amoxapine is primarily used to treat major depressive disorder (MDD), a common and disabling mental illness characterized by persistent sadness, hopelessness, and loss of interest in daily activities. It also treats certain types of psychosis, including schizophrenia and schizoaffective disorder, due to its antipsychotic effects.Â
amoxapine belongs to tricyclic antidepressants, which work by increasing the concentration of certain neurotransmitters in the brain, including norepinephrine and serotonin. By increasing these neurotransmitters’ activity, amoxapine helps improve mood, reduce anxiety, and increase energy and motivation.Â
amoxapine is particularly useful in treating depression with accompanying anxiety, agitation, and sleep disturbances. It is also helpful in treating depression that has not responded to other antidepressant medications or in patients who cannot tolerate the side effects of other antidepressants.Â
In addition to its antidepressant effects, amoxapine has antipsychotic properties that make it helpful in treating certain types of psychosis. It effectively reduces hallucinations, delusions, and other psychotic symptoms and is often used with other antipsychotic medications. Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
