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Brand Name :
Priligy
Synonyms :
Dapoxetine
Class :
SSRI
Brand Name :
Priligy
Synonyms :
Dapoxetine
Class :
SSRI
 Dosage Forms & Strengths:Â
TabletÂ
30 mgÂ
60 mgÂ
Drug-Induced Sexual DysfunctionÂ
Take a dose of 30 mg orally one time daily
Dose Adjustments
Limited data is available
Pediatric Â
Not determined Â
Refer to the adult dosing
May have an increased serotonergic effect when combined with Serotonergic Agents
may enhance the concentration of serum when combined with dapoxetine
may enhance the concentration of serum when combined with dapoxetine
may enhance the concentration of serum when combined with dapoxetine
may enhance the concentration of serum when combined with dapoxetine
may enhance the concentration of serum when combined with dapoxetine
dapoxetine: they may enhance the serum concentration of CYP3A Inhibitors
dapoxetine: they may enhance the serum concentration of CYP3A Inhibitors
dapoxetine: they may enhance the serum concentration of CYP3A Inhibitors
dapoxetine: they may enhance the serum concentration of CYP3A Inhibitors
dapoxetine: they may enhance the serum concentration of CYP3A Inhibitors
dapoxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
dapoxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
dapoxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
dapoxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
dapoxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 Inhibitors
dapoxetine: they may increase the toxic effect of mu-opioid receptor agonists
dapoxetine: they may increase the toxic effect of mu-opioid receptor agonists
may increase the orthostatic hypotensive effect of dapoxetine
may increase the orthostatic hypotensive effect of dapoxetine
may increase the orthostatic hypotensive effect of dapoxetine
may increase the orthostatic hypotensive effect of dapoxetine
may increase the orthostatic hypotensive effect of dapoxetine
may have an increased orthostatic hypotensive effect when combined with calcium channel blockers
may have an increased orthostatic hypotensive effect when combined with calcium channel blockers
may have an increased orthostatic hypotensive effect when combined with calcium channel blockers
may have an increased orthostatic hypotensive effect when combined with calcium channel blockers
may have an increased orthostatic hypotensive effect when combined with calcium channel blockers
may have an increased orthostatic hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased orthostatic hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased orthostatic hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased orthostatic hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased orthostatic hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased orthostatic hypotensive effect when combined with vasodilators
may have an increased orthostatic hypotensive effect when combined with vasodilators
may have an increased orthostatic hypotensive effect when combined with vasodilators
may have an increased orthostatic hypotensive effect when combined with vasodilators
may have an increased orthostatic hypotensive effect when combined with vasodilators
dapoxetine: they may increase the orthostatic hypotensive effect of Angiotensin II Receptor antagonists
dapoxetine: they may increase the orthostatic hypotensive effect of Angiotensin II Receptor antagonists
dapoxetine: they may increase the orthostatic hypotensive effect of Angiotensin II Receptor antagonists
dapoxetine: they may diminish the serum concentration of CYP3A4 Inducers
dapoxetine: they may diminish the serum concentration of CYP3A4 Inducers
dapoxetine: they may diminish the serum concentration of CYP3A4 Inducers
dapoxetine: they may diminish the serum concentration of CYP3A4 Inducers
dapoxetine: they may diminish the serum concentration of CYP3A4 Inducers
dapoxetine: they may increase the CNS depressant effect of CNS Depressants
dapoxetine: they may increase the CNS depressant effect of CNS Depressants
dapoxetine: they may increase the CNS depressant effect of CNS Depressants
dapoxetine: they may increase the CNS depressant effect of CNS Depressants
dapoxetine: they may increase the CNS depressant effect of CNS Depressants
the metabolism of dapoxetine may decrease when combined with amprenavir
nicorandil is used with caution when dapoxetine is prescribed, as it can have reduced orthostatic tolerance
amitriptylinoxide(Phase 4 Clinical Trials)Â
combining amitriptylinoxide with dapoxetine may increase the intensity of adverse effects
the intensity of adverse effects can be elevated when amobarbital is combined with dapoxetine
dapoxetine may enhance the intensity of orthostatic hypotensive effects of amoxapine
combining amphetamine with dapoxetine may increase the intensity of serotonin syndrome
dapoxetine may augment the intensity of orthostatic hypotensive and hypotensive effects of amyl nitrite
combining anagrelide with dapoxetine may increase the intensity of hemorrhage
the metabolism of dapoxetine may be increased when combined with anakinra
Actions and Spectrum:Â
Premature ejaculation is a condition in which sexual dysfunction occurs due to rapid ejaculation during sexual intercourse.Â
The drug is taken between 18 to 64 years old in men. Â
Frequency not definedÂ
Serotonin syndromeÂ
HeadacheÂ
TinnitusÂ
SyncopeÂ
AgitationÂ
FlatulenceÂ
RestlessnessÂ
Increased bleeding riskÂ
HyponatremiaÂ
Erectile dysfunctionÂ
YawningÂ
VomitingÂ
DiarrheaÂ
SeizuresÂ
Dry mouthÂ
FatigueÂ
Abdominal painÂ
DyspepsiaÂ
TremorÂ
HTNÂ
ParesthesiaÂ
Abnormal dreamsÂ
AnxietyÂ
Sinus congestionÂ
Black box warning:Â
The drug should be used on own, not with others. Â
Always take to the prescribed dosage and never exceed it. Â
Contraindication/Caution:Â
Contraindications:Â
HypersensitivityÂ
WomenÂ
PediatricsÂ
Cautions:Â
Renal impairmentÂ
Cardiovascular disordersÂ
EpilepsyÂ
Hepatic impairmentÂ
Drug interactionsÂ
GlaucomaÂ
Pregnancy Warnings:Â Â
Pregnancy category: N/AÂ Â
Lactation:Â Â
Excretion of the drug in human breast milk is unknown Â
Pregnancy Categories:Â Â Â Â
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.   Â
<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.   Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.   Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.   Â
Category N: There is no data available for the drug under this category.     Â
Â
Pharmacology:Â
Dapoxetine belongs to the class of selective serotonin reuptake inhibitors.Â
It increases the time taken for ejaculation during intercourse. For the best results, it is suggested to take dapoxetine a few hours before sexual activity. Â
Pharmacodynamics:Â
The mechanism of dapoxetine increases neurotransmitter activity linked to its inhibition of neuronal serotonin reuptake.Â
Pharmacokinetics:Â
AbsorptionÂ
The plasma peak effect is achieved within 1 to 2 hours.Â
DistributionÂ
The protein-bound ratio was found to be about 99.99%.Â
MetabolismÂ
It undergoes extensive metabolism by various enzymes.Â
Elimination and ExcretionÂ
It is eliminated through urine.Â
Administration:Â
Dapoxetine is taken orally as prescribed. Â
Patient information leaflet:Â
Generic Name: dapoxetineÂ
Why do we use dapoxetine?Â
Dapoxetine widely used in management of premature ejaculation in men.
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