Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
lunesta
Synonyms :
eszopiclone
Class :
Sedative, Hypnotics
Brand Name :
lunesta
Synonyms :
eszopiclone
Class :
Sedative, Hypnotics
Dosage Forms & StrengthsÂ
TabletÂ
1 mgÂ
2 mgÂ
3 mgÂ
Initial dose: 1mg orally before bedtime
Maintenance dose: 1-3mg orally before bedtime
Maximum dose:3mg/kg
Dose Adjustments
The starting dose for those taking a CYP3A inhibitor should not exceed 1 mg. No dose adjustment is required for mild to moderate renal impairment, but those with severe hepatic impairment should start with 1 mg PO HS
Dosage adjustments may be necessary to avoid additive effects when eszopiclone is coadministered with another central nervous system (CNS) depressant
Safety and efficacy not determinedÂ
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may enhance the serum concentration of CYP3A4 inhibitors
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
CYP3A strong enhancers of the small intestine may reduce the bioavailability of eszopiclone 
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the CNS depressing effect of paraldehyde
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
eszopiclone: they may diminish the serum concentration of CYP3A4 Inducers
eszopiclone: they may diminish the serum concentration of CYP3A4 Inducers
eszopiclone: they may diminish the serum concentration of CYP3A4 Inducers
eszopiclone: they may diminish the serum concentration of CYP3A4 Inducers
eszopiclone: they may diminish the serum concentration of CYP3A4 Inducers
eszopiclone: they may enhance the serum concentration of CYP3A4 inhibitors
eszopiclone: they may enhance the serum concentration of CYP3A inhibitors
eszopiclone: they may enhance the serum concentration of CYP3A inhibitors
eszopiclone: they may enhance the serum concentration of CYP3A inhibitors
eszopiclone: they may enhance the serum concentration of CYP3A inhibitors
eszopiclone: they may enhance the serum concentration of CYP3A inhibitors
the effect of eszopiclone is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CNS Depressants may enhance the CNS depressant effect of brexanolone
CNS Depressants may enhance the CNS depressant effect of thalidomide
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may increase the toxic effects
Action and Spectrum:Â
Eszopiclone binds to gamma-aminobutyric acid receptors in the brain. It increases GABA effect to regulate central nervous system inhibition.Â
Adverse reaction:Â
>10%Â
Unpleasant tasteÂ
HeadacheÂ
1-10%Â
Abnormal dreamsÂ
DyspepsiaÂ
NervousnessÂ
SomnolenceÂ
DizzinessÂ
Dry mouthÂ
Unpleasant tasteÂ
UTIÂ
<1%Â
AgitationÂ
AlopeciaÂ
DysphagiaÂ
FeverÂ
AnorexiaÂ
CystitisÂ
HypercholesterolemiaÂ
Black box warning:Â
Therapy may lead to complex sleep behaviours like sleepwalking and sleep-driving to cause serious injuries.Â
In such cases discontinue therapy immediately if patient experiences a complex sleep behaviour.Â
Contraindications/caution:Â
Contraindications:Â
Cautions:Â
Pregnancy Warnings:Â
Pregnancy category: N/AÂ
Lactation: Excretion of the drug into the human breast milk is unknownÂ
Pregnancy categories:Â
Pharmacology: Chloride ion influx hyperpolarizes neuron to decreases excitability and reduces activity.Â
The modulation induces a sedative state in sleep induction and reduce sleep latency to prolongs sleep duration and enhances quality.Â
Pharmacodynamics: The specificity with the GABA-A receptors benzodiazepine site causes sedation without usual side effects.Â
Prolonged use may lead to tolerance, dependence, and withdrawal symptoms.Â
Pharmacokinetic:Â
Absorption:Â
It reaches peak plasma time in 1 hours.Â
Distribution:Â
It shows protein bound of 52% to 59%.Â
Metabolism:Â
The metabolites such as S-desmethylzopiclone and zopiclone-N-oxide are largely inactive.Â
Excretion and elimination:Â
It is excreted through urine route.Â
Administration:Â
It is taken orally in form of tablet.Â
Patient information leaflet:Â
Generic Name: eszopicloneÂ
Why do we use eszopiclone?Â
Eszopiclone is used in treatment for insomnia.Â
It is used to improve sleep maintenance, and overall sleep quality of patient.Â
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