Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
Tropex
(Finland) [Available]Synonyms :
Phenazone , Analgesine, Fenazon, Antipyrine, Phenazon, Fenazona
Class :
Otic anesthetics
Dosage forms and strengths Â
Tropex (Ear Drops)Â Â
phenazone (5%)Â
(Off-label):
Indicated for pain associated with inflammation of the ear
Instill the ear drops into the external auditory canal
4 to 6 drops 3 to 4 times a day adjusting the frequency based on the extent of the inflammation
Not indicatedÂ
Refer adult dosingÂ
may diminish the excretion rate of amantadine
antipyrine: it may increase the risk of QTc prolongation agents
antipyrine: it may increase the risk of QTc prolongation agents
antipyrine: it may increase the risk of QTc prolongation agents
antipyrine: it may increase the risk of QTc prolongation agents
antipyrine: it may increase the risk of QTc prolongation agents
it may diminish the metabolism when combined with diosmin
levobetaxolol's antihypertensive properties may be reduced by antipyrine
The combination of levobupivacaine can lead to a reduction in the metabolism of antipyrine
Combining antipyrine with pranlukast may cause a reduction in the antipyrine metabolism
antipyrine has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
Combining tegafur with antipyrine can reduce tegafur’s metabolism
It may enhance the risk of adverse effects when combined with Glycopeptides
It may enhance the risk of adverse effects when combined with Glycopeptides
When loracarbef is used together with antipyrine, the risk or seriousness of nephrotoxicity is enhanced
When antipyrine is used together with hexoprenaline, the potential for hypertension to occur may be elevated
When antipyrine is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When antipyrine is used together with fluconazole, this leads to reduction in the antipyrine metabolism
When antipyrine is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When antipyrine is used together with somatotropin, this leads to a rise in aminophylline’s metabolism
When antrafenine is used together with antipyrine, this leads to enhanced risk or seriousness of adverse outcomes
When antipyrine is used together with cephaloglycin, this leads to increased risk or seriousness of nephrotoxicity
When melitracen is used together with antipyrine, this leads to increased risk or seriousness of gastrointestinal bleeding
When antipyrine is used together with promazine, this leads to a reduction in antipyrine metabolism
When antipyrine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When antipyrine is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When antipyrine is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
when antipyrine is coupled with zomepirac, the risk or severity of undesirable effects can be enhanced
When antipyrine is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
antipyrine leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
antipyrine leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
antipyrine leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
When indisulam is used together with antipyrine, this leads to a reduction in antipyrine metabolism
When antipyrine is used together with difenpiramide, this leads to increased risk or seriousness of adverse events
antipyrine: it may decrease the metabolism of oxtriphylline
antipyrine: it may decreased the serum concentration of CNS depressants
antipyrine: it may decreased the serum concentration of CNS depressants
antipyrine: it may decreased the serum concentration of CNS depressants
antipyrine: it may decreased the serum concentration of CNS depressants
antipyrine: it may decreased the serum concentration of CNS depressants
combining zimelidine with antipyrine may increase the chances of gastrointestinal bleeding
the chances of adverse effects can be heightened when antipyrine is combined with morniflumate
the risk or extent of methemoglobinemia can be raised when antipyrine is combined with isometheptene
antipyrine may decrease the excretion rate of almasilate, leading to higher serum levels
When antipyrine is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
antipyrine: it may decrease the metabolism of rosoxacin
NSAIDs may enhance the adverse/toxic effect of metformin
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
Combining antipyrine with abametapir may lead to an elevation in the concentration serum of antipyrine
The combination of antipyrine with abciximab might elevate the severity of hemorrhage & bleeding
When antipyrine is combined with abiraterone, its concentration serum may also elevated
antipyrine with abrocitinib could potentially lead to a reduce in the metabolism of abrocitinib.
antipyrine has been observed to potentially reduce the antihypertensive effects of acebutolol
The combination of antipyrine with aceclofenac may elevate the seriousness of adverse events
The combination of antipyrine with acemetacin may elevate the seriousness of adverse events
There is a potential increase in the seriousness of hemorrhage and bleeding when antipyrine is used together with acenocoumarol
The combination of antipyrine with amoxapine can elevate the risk or seriousness of gastrointestinal bleeding
antipyrine has the potential to reduce the rate of excretion of amoxicillin, leading to a potential elevation in the serum levels
The potential for elevated risk or seriousness of hypertension may arise when amphetamine is utilized concurrently with antipyrine
antipyrine has the potential to reduce the rate of excretion of ampicillin, potentially leading to an elevation in the serum concentration
antipyrine has the potential to reduce the rate of excretion of amrinone, potentially leading to an elevation in the serum concentration
The potential for methemoglobinemia to occur may be enhanced when amyl nitrite is used concurrently with antipyrine
The potential for bleeding to occur at a higher risk or increased severity when antipyrine is used in conjunction with anagrelide
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
an increase in the severity of adverse effects can be seen if antipyrine is taken with bumadizone
may have a decrease in excretion when combined with antipyrine
the risk of adverse effects may be increased
the rate of metabolism of roxadustat may be reduced
the risk of hypertension may be increased
the therapeutic effect of Remikiren may be reduced
the risk of adverse effects may be increased
the risk of methemoglobinemia may be increased
When antipyrine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
antipyrine might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum:Â
Action:Â
Analgesic Action: antipyrine’s analgesic properties are attributed to its ability to hinder the synthesis of prostaglandins, which are bioactive compounds that play a crucial role in inflammation and pain transmission. Through this mechanism, antipyrine effectively mitigates pain symptoms.Â
Antipyretic Action: antipyrine demonstrates antipyretic properties by influencing the hypothalamus, which is responsible for controlling body temperature. Its mechanism involves resetting the body’s temperature set-point, leading to a reduction in fever and facilitating the restoration of normal body temperature.Â
Spectrum:Â Â
Pain Relief: Frequently employed for alleviating mild to moderate pain arising from different conditions like headaches, toothaches, menstrual cramps, and musculoskeletal injuries.Â
Fever Reduction: antipyrine is effective in reducing fever associated with various infections, illnesses, or inflammatory conditions.Â
Frequency not defined Â
Not reportedÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Allergy or hypersensitivity: Individuals with a known allergy or hypersensitivity to antipyrine or any of its components should avoid using this medication.Â
Blood Disorders: antipyrine may affect blood cell counts and could be dangerous for individuals with certain blood disorders, such as aplastic anemia or agranulocytosis.Â
Liver or Kidney Impairment: Patients with severe liver or kidney impairment may not be able to effectively metabolize or eliminate antipyrine from their bodies, leading to potential adverse effects.Â
Gastrointestinal Ulcers or Bleeding: antipyrine can irritate the gastrointestinal tract and may worsen existing ulcers or cause gastrointestinal bleeding.Â
Alcohol Use Disorder: Combining antipyrine with alcohol can increase the risk of liver damage.Â
Pregnancy and Breastfeeding: The safety of antipyrine during pregnancy and breastfeeding is not well-established, so it should be used with caution, and only if the potential benefits outweigh the risks.Â
Children: Dosage and safety considerations may differ for children, and it’s essential to follow the guidance of a pediatrician when administering antipyrine to children.Â
Aspirin or NSAID Allergy: antipyrine may sometimes be combined with other medications, including aspirin or non-steroidal anti-inflammatory drugs (NSAIDs). If you have a known allergy to aspirin or NSAIDs, be cautious with antipyrine combinations.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â Â
antipyrine, also known as phenazone, is an analgesic and antipyretic medication used to relieve pain and reduce fever.Â
Pharmacodynamics:Â Â
antipyrine works primarily by inhibiting the synthesis of prostaglandins, which are chemical messengers that promote inflammation, pain, and fever. It specifically inhibits the activity of the (COX), which is involved in the production of prostaglandins. By reducing prostaglandin levels, antipyrine helps to alleviate pain and reduce fever.  Â
Pharmacokinetics:Â
AbsorptionÂ
antipyrine is well-absorbed from the gastrointestinal tract after oral administration. It reaches peak blood levels within 1 to 2 hours after ingestion.Â
DistributionÂ
The drug is broadly distributed all over the body and can cross the blood-brain barrier. It is primarily bound to plasma proteins.Â
MetabolismÂ
antipyrine undergoes extensive metabolism in the liver. It is mainly metabolized by the cytochrome P450 enzyme system, specifically the CYP1A2 isoenzyme.Â
Excretion and EliminationÂ
The metabolites of antipyrine are primarily excreted in the urine. The elimination half-life of antipyrine is relatively short, typically around 12 to 16 hours.Â
Administration: Â
antipyrine is usually administered orally in the form of tablets, capsules, or liquid. It can be taken with or without food, but it is generally recommended to take it with a glass of water to help with absorption. For children and those who have difficulty swallowing tablets, liquid formulations are available and may be more suitable.Â
Â
Patient information leafletÂ
Generic Name: antipyrineÂ
Why do we use antipyrine? Â
Pain Relief: antipyrine is a medication utilized to relieve mild to moderate pain, including headaches, musculoskeletal pain, and dental pain.Â
Fever Reduction: It is also used to reduce fever associated with various conditions, such as infections and inflammatory disorders.Â
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