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Brand Name :
Alginor, Ibscim
Synonyms :
cimetropium ion, cimetropium bromide
Class :
Neuropsychiatric agent, Muscarinic cholinergic receptor antagonist
Brand Name :
Alginor, Ibscim
Synonyms :
cimetropium ion, cimetropium bromide
Class :
Neuropsychiatric agent, Muscarinic cholinergic receptor antagonist
Dosage forms& Strengths
Tablet
50 mg
Irritable Bowel Syndrome (IBS)
It is indicated in the treatment of IBS
The recommended usual dose via oral administration is 50 mg three times per day
Dose Adjustments
Limited data is available
Safety and efficacy studies are not seen in pediatrics
Refer to the adult dosing
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the bradycardic effect of Bradycardia-Causing Agents
cimetropium: they may increase the bradycardic effect of Bradycardia-Causing Agents
cimetropium: they may increase the bradycardic effect of Bradycardia-Causing Agents
cimetropium: they may increase the bradycardic effect of Bradycardia-Causing Agents
cimetropium: they may increase the bradycardic effect of Bradycardia-Causing Agents
cimetropium: they may enhance the serum concentration of CYP3A4 Inhibitors
cimetropium: they may enhance the serum concentration of CYP3A4 Inhibitors
cimetropium: they may enhance the serum concentration of CYP3A4 Inhibitors
cimetropium: they may enhance the serum concentration of CYP3A4 Inhibitors
cimetropium: they may enhance the serum concentration of CYP3A4 Inhibitors
acrivastine and pseudoephedrine
may increase the anticholinergic effect of anticholinergic agents
may have an increased anticholinergic effect when combined with cimetropium
may have an increased anticholinergic effect when combined with cimetropium
may have an increased anticholinergic effect when combined with cimetropium
may have an increased anticholinergic effect when combined with cimetropium
may have an increased anticholinergic effect when combined with cimetropium
anticholinergic agents increase the efficacy of cimetropium
anticholinergic agents increase the efficacy of cimetropium
anticholinergic agents increase the efficacy of cimetropium
anticholinergic agents increase the efficacy of cimetropium
anticholinergic agents increase the efficacy of cimetropium
anticholinergic agents increase the effect of cimetropium
anticholinergic agents increase the effect of cimetropium
anticholinergic agents increase the effect of cimetropium
anticholinergic agents increase the effect of cimetropium
anticholinergic agents increase the effect of cimetropium
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may increase the CNS depressant effect of CNS Depressants
cimetropium: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetropium: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetropium: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetropium: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetropium: they may enhance the serum concentration of CYP2D6 Inhibitors
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of Anticholinergic Agents
may increase the anticholinergic effect of Anticholinergic Agents
may increase the anticholinergic effect of Anticholinergic Agents
cimetropium: they may increase the hypertensive effect of sympathomimetics
cimetropium: they may increase the hypertensive effect of sympathomimetics
cimetropium: they may increase the hypertensive effect of sympathomimetics
cimetropium: they may increase the hypertensive effect of sympathomimetics
cimetropium: they may increase the hypertensive effect of sympathomimetics
the anticholinergic activities of cimetropium may be reduced by acetylcholine
when combined with cimetropium, there is an increased chances of adverse effects with aclidinium
the anticholinergic activities of cimetropium may be reduced by bethanechol
may decrease the anticholinergic effect of cholinergic agonists
the adverse effects of amitriptyline may be increased when combined with cimetropium
when amoxapine is combined with cimetropium, the chances of adverse effects may be increased
when combined with cimetropium, there is an increased risk or severity of adverse effects with aripiprazole
the adverse effects of benzatropine may be increased when combined with cimetropium
Actions and spectrum:
Cimetropium bromide is a medicine that helps in easing stomach discomfort by stopping and calming the intestines from shrinking because it’s in the group of anti-spasmodic as well as anti-cholinergic drugs.
Adverse reactions
Tachycardia
Dry skin
Flushing
Bradycardia
Dry mouth
Difficulty urinating
Palpitations
Reduced bronchial secretions
Arryhtmias
Reduced GI tone
Pupil dilation
Nausea
Vomiting
Fever
Sleeplessness
Cough
Skin rash
Headache
Dizziness
Itching
Loss of accommodation
Black box warning
This medication is not recommended for use in individuals with certain medical conditions, including glaucoma, intestinal obstruction, prostatic hyperplasia, cardiac arrhythmias, urinary retention, chronic airway obstruction, reflux esophagitis, and congestive heart failure.
Contraindications/Caution
Contraindications
Hypersensitivity
Prostatic enlargement
Pyrolic stenosis
Paralytic ileus
Cautions
Renal impairment
Diarrhea
Thyrotoxicosis
Fever
Hepatic impairment
Cardiac surgery or heart failure
Drug interactions
Pregnancy
Breastfeeding
Pregnancy & breastfeeding:
Pregnancy consideration:
Data about the safety and efficacy studies in pregnancy is not available
Breastfeeding warnings:
Data regarding the secretion of drug into human milk is not available
Pregnancy category:
Pharmacology:
Cimetropium, a semi-synthetic alkaloid obtained from belladonna derived from scopolamine. It is an antispasmodic and antimuscarinic agent.
Pharmacodynamics:
Cimetropium bromide is an anticholinergic agent that works by preventing muscarinic cholinergic receptors from functioning, without regard to their specific type. As a result of this blockage, the production of cyclic guanosine monophosphate (cGMP) is decreased leading to reduced smooth muscle contractility which may be due predominantly via decreased intracellular calcium action mediated by cGMP.
Pharmacokinetics:
Limited data available
Administration:
This tablet should be taken orally, with or without food. It would be better to administer this tablet on the same time every day.
Patient information leaflet
Generic Name: cimetropium
Why do we use cimetropium?
This is an antispasmodic and antimuscarinic agent indicated in treating irritable bowel syndrome. It works by causing relaxation of the intestinal muscles.
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