Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Avamys
(Canada) [Available]Synonyms :
fluticasone
Class :
Drugs for asthma and COPD & Corticosteroid (nasal)
Brand Name :
Avamys
(Canada) [Available]Synonyms :
fluticasone
Class :
Drugs for asthma and COPD & Corticosteroid (nasal)
Dosage Forms & Strengths
Nasal Suspension, as propionate
93 mcg/actuation
50 mcg/actuation
Nasal Suspension, as furoate:
27.5 mcg/spray
Allergic/Non-allergic:
Fluticasone furoate 27.5 mcg/spray or Fluticasone propionate 50 mcg/spray):
2 sprays in each nostril once a day
Note: Reduce 1 spray in each nostril upon controlled symptoms
With or without nasal polyps:
Fluticasone furoate 27.5 mcg/spray or Fluticasone propionate 50 mcg/spray):
2 sprays in each nostril once a day
Note: Reduce 1 spray in each nostril upon controlled symptoms
Dosage Forms & Strengths
Nasal Suspension, as propionate:
93 mcg/actuation
50 mcg/actuation
Nasal Suspension, as furoate:
27.5 mcg/spray
Fluticasone furoate:
For Children 2 to 11 years: 1 spray (55 mcg) per nostril once a day
Increase the dose to 2 sprays (110 mcg) per nostril depending on the symptoms
Fluticasone propionate:
For Children 4 to 11 years: 1 to 2 sprays (100 to 200 mcg/day) per nostril once a day (do not exceed 2 sprays (total dose 400 mcg/day) per nostril once a day)
Refer to adult dosing
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
measles, mumps, rubella, and varicella vaccine, live (Rx)
it may increase the risk of adverse effects of vaccines
measles mumps and rubella vaccine, live
it may increase the risk of adverse effects of vaccines
it may increase the risk of adverse effects of vaccines
smallpox (vaccinia) vaccine, live
it may increase the risk of adverse effects of vaccines
it may increase the risk of adverse effects of vaccines
measles, mumps, rubella, and varicella vaccine, live (Rx)
it may increase the risk of adverse effects of vaccines
measles mumps and rubella vaccine, live
it may increase the risk of adverse effects of vaccines
it may increase the risk of adverse effects of vaccines
smallpox (vaccinia) vaccine, live
it may increase the risk of adverse effects of vaccines
it may increase the risk of adverse effects of vaccines
may decrease the therapeutic effect when combined with covid-19 vaccine
respiratory syncytial virus vaccine, adjuvanted
may decrease the therapeutic effect when combined with influenza virus vaccines
respiratory syncytial virus (RSV) vaccine
may decrease the therapeutic effect when combined with influenza virus vaccines
may decrease the therapeutic effect when combined with influenza virus vaccines
respiratory syncytial virus vaccine, adjuvanted
may decrease the therapeutic effect when combined with influenza virus vaccines
respiratory syncytial virus (RSV) vaccine
may decrease the therapeutic effect when combined with influenza virus vaccines
poliovirus vaccine, live, trivalent
may decrease the therapeutic effect when combined with influenza virus vaccines
poliovirus vaccine inactivated
may decrease the therapeutic effect when combined with influenza virus vaccines
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may enhance the risk of adverse effect of corticosteroids
may decrease the therapeutic effect of hyaluronidase
antacids: they may diminish the bioavailability of corticosteroids
antacids: they may diminish the bioavailability of corticosteroids
antacids: they may diminish the bioavailability of corticosteroids
antacids: they may diminish the bioavailability of corticosteroids
may diminish the bioavailability of Antacids
may diminish the bioavailability of Antacids
aluminum hydroxide/magnesium carbonate
may decrease the bioavailability of antacids
sipuleucel-T: they may decrease the therapeutic effect of corticosteroids
sipuleucel-T: they may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of each other when combined
may decrease the therapeutic effect of each other when combined
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may diminish the anti-neoplastic activity of corticosteroids
may enhance the serum concentration when combined
may increase the hyponatremic effect when combined
indium In-111 capromab pendetide
may decrease the diagnostic effect when combined
indium In-111 capromab pendetide
may decrease the diagnostic effect when combined
It may decrease the antineoplastic effect when combined with Corticosteroids
It may decrease the antineoplastic effect when combined with Corticosteroids
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of NSAIDs
may enhance the adverse effect of quinolones
may enhance the adverse effect of quinolones
may enhance the adverse effect of quinolones
may enhance the adverse effect of quinolones
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the serum concentration
may increase the serum concentration
bazedoxifene/conjugated estrogens
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
bazedoxifene/conjugated estrogens
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
They may diminish the absorption when combined with bile acid sequestrants
They may diminish the absorption when combined with bile acid sequestrants
corticosteroids j3: they may increase the anticoagulant effect of anticoagulants
corticosteroids j3: they may increase the anticoagulant effect of anticoagulants
corticosteroids j3: they may increase the anticoagulant effect of anticoagulants
corticosteroids j3: they may increase the anticoagulant effect of anticoagulants
corticosteroids j3: they may increase the anticoagulant effect of anticoagulants
corticosteroids j4: they may increase the anticoagulant effect of anticoagulants
corticosteroids j4: they may increase the anticoagulant effect of anticoagulants
corticosteroids j4: they may increase the anticoagulant effect of anticoagulants
corticosteroids j4: they may increase the anticoagulant effect of anticoagulants
corticosteroids j4: they may increase the anticoagulant effect of anticoagulants
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
sodium picosulfate, citric acid, and magnesium oxide
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
sodium picosulfate, citric acid, and magnesium oxide
may diminish the effect of each other when combined
may have an increasingly adverse effect when combined with acetylcholinesterase inhibitors
may have an increasingly adverse effect when combined with acetylcholinesterase inhibitors
relugolix/estradiol/norethindrone
may have an increased fluid-retaining effect when combined with androgens
relugolix/estradiol/norethindrone
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may decrease the therapeutic effect when combined with covid-19 vaccine
may decrease the therapeutic effect when combined with agents of urea cycle disorder
relugolix/estradiol/norethindrone
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
spironolactone and hydrochlorothiazide
may increase the hypokalemic effect when combined with diuretics
may increase the hypokalemic effect when combined with diuretics
may increase the hypokalemic effect when combined with diuretics
may increase the hypokalemic effect when combined with diuretics
may increase the hypokalemic effect when combined with diuretics
may have an increasingly adverse effect when combined with NSAIDs
may reduce the rate of absorption of corticosteroids
may reduce the rate of absorption of corticosteroids
choline magnesium trisalicylate
may enhance the adverse effect of corticosteroids
choline magnesium trisalicylate
may enhance the adverse effect of corticosteroids
may increase the hypokalemic effect of amphotericin
may increase the hypokalemic effect of amphotericin
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
It may enhance the serum concentration when combined with Corticosteroids (ophthalmic)
It may enhance the serum concentration when combined with Corticosteroids (ophthalmic)
It may enhance the serum concentration when combined with Corticosteroids (ophthalmic)
It may enhance the serum concentration when combined with Corticosteroids (ophthalmic)
It may increase the adverse effects when combined with Corticosteroids (Ophthalmic)
It may increase the adverse effects when combined with Corticosteroids (Ophthalmic)
It may increase the adverse effects when combined with Corticosteroids (Ophthalmic)
It may increase the adverse effects when combined with Corticosteroids (Ophthalmic)
It may increase the adverse effects when combined with Corticosteroids (Ophthalmic)
estrogens esterified/methyltestosterone
may enhance the serum concentration of estrogen derivatives
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
ciprofloxacin inhaled (Pending FDA approval)
May increase the toxic effect of Quinolones
may increase the toxic effect of Acetylcholinesterase Inhibitors
may increase the toxic effect of Acetylcholinesterase Inhibitors
cyproterone and ethinyl estradiol
may enhance the serum concentration of Estrogen Derivatives
etonogestrel/ethinyl estradiol
may increase the serum concentration of estrogen derivatives
may enhance the serum concentration of each other when combined
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
sodium bicarbonate: they may decrease the therapeutic effect of corticosteroids J3
sodium bicarbonate: they may decrease the therapeutic effect of corticosteroids J4
sodium phenylbutyrate: they may decrease the therapeutic effect of corticosteroids J3
probenecid: they may decrease the therapeutic effect of corticosteroids J3
valproic acid: they may decrease the therapeutic effect of corticosteroids J3
may decrease the anti-neoplastic effect of each other when combined
may decrease the anti-neoplastic effect of each other when combined
may enhance the concentration of serum when combined with corticosteroids
may enhance the concentration of serum when combined with corticosteroids
bazedoxifene/conjugated estrogens
may enhance the concentration of serum when combined with corticosteroids
may enhance the concentration of serum when combined with corticosteroids
may enhance the concentration of serum when combined with corticosteroids
may decrease the therapeutic effect when combined with covid-19 vaccine
may enhance the concentration of serum when combined with corticosteroids
may enhance the concentration of serum when combined with corticosteroids
bazedoxifene/conjugated estrogens
may enhance the concentration of serum when combined with corticosteroids
may enhance the concentration of serum when combined with corticosteroids
may enhance the concentration of serum when combined with corticosteroids
Actions and Spectrum
In humans, it stimulates glucocorticoid receptors and leads to a highly effective anti-inflammatory response. Lastly, fluticasone acts on numerous cells and mediators involved in the development of inflammation and symptoms that characterise allergic rhinitis.
Adverse Reaction
Frequency defined
>10%
Headache
Epistaxis
1% to 10%
Localized erythema
Fever
Abdominal stress
Weight gain
Diarrhea
Dizziness
Dry nose
Blood in the nasal mucosa
<1%
Esophageal candidiasis
Nasal candidiasis
Pharyngeal candidiasis
Black Box Warning
None
Contraindication/Caution
Contraindications
Hypersensitivity
Cautions
Infection and Immunosuppression
Hypercorticism and suppression of adrenal glands
Pregnancy/Lactation
Pregnancy consideration: Limited use in usual doses preferred to avoid increased risk of fetal malformations.
Lactation: Fluticasone excretion in breast milk is not known.
Pregnancy category:
Pharmacology
Fluticasone is a second-generation synthetic corticosteroid that has a high degree of anti-inflammatory activity. It acts mainly through receptor binding which includes glucocorticoid receptors preventing the release of pro-inflammatory compounds and decreasing the function of several inflammation cells.
Pharmacodynamics
At the systemic level, in vitro studies have revealed that fluticasone furoate acts on the glucocorticoid receptors, antagonises nuclear factor kappa B and has a dose dependent inhibition of lung eosinophilia in rats. As stated above, fluticasone propionate has analogous activities but its impact on the nuclear factor kappa B is unknown. Fluticasone propionate in topical formulation impacts on vasoconstriction in the skin and affects blood flow.
Pharmacokinetics
Absorption
It has a peak plasma concentration: 17.2 pg/mL for a 186-mcg dose and
25.3 pg/mL for a 372-mcg dose.
The area under the curve (AUC) is 111.7 pg·h/mL for a 186-mcg dose and 171.7 pg·h/mL for a 372-mcg dose.
The bioavailability is ≤2%
Distribution
Volume of distribution (Vd)- 4.2 L/kg and exhibits 99% protein binding.
Metabolism
It is metabolized by the CYP3A4 pathway. The only circulating metabolite detected in humans is the 17β-carboxylic acid derivative of fluticasone propionate.
Elimination/Excretion
Half-life of fluticasone -7.8 hours
Clearance rate-1093 mL/min.
Renal clearance accounts for less than 0.02% of the total clearance. Excretion occurs through urine (<5%) and feces, with the remaining amount excreted as the parent drug and metabolite.
Administration
The route of administration is intranasal
Patient information leaflet
Generic Name: fluticasone (nasal)
Why do we use fluticasone (nasal)?
Esters of fluticasone are prescribed as inhalers for the prophylactic treatment and management of asthma as well as inflammatory and itchy dermatoses.
For the treatment of nonallergic rhinitis, a nasal spray is recommended.
It is also indicated for treating season and perennial allergic rhinitis.
It is used in treatment of chronic rhinosinusitis with nasal polyps.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
