Alcohol Consumption Emerges as a Key Risk Factor for Buccal Cancer in India
December 24, 2025
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Brand Name :
No Data Available.
Synonyms :
hydrocodone and homatropine
Class :
Narcotic Combos, Antitussives
Brand Name :
No Data Available.
Synonyms :
hydrocodone and homatropine
Class :
Narcotic Combos, Antitussives
Dosage Forms & Strengths
Tablet: Schedule II
5mg/1.5mg
oral solution: Schedule II
(5mg/1.5mg)/5mL
5 mg/1.5 mg orally every 4-6 hours
Dosage Forms & Strengths
Tablet: Schedule II
5mg/1.5mg
oral solution: Schedule II
(5mg/1.5mg)/5mL
5 mg/1.5 mg orally every 4-6 hours
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
may have an increased Effect of CNS depressant when combined with serotonergic opioids
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
amoxicillin/omeprazole/rifabutin
may affect the absorption of drugs when combined
may affect the absorption of drugs when combined
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
it may enhance the QTc-prolonging effect
it may enhance the QTc-prolonging effect
it may enhance the QTc-prolonging effect
it may enhance the QTc-prolonging effect
it may enhance the QTc-prolonging effect
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
it may increase the levels of serum concentration
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
it may decrease the levels of serum concentration
it may decrease the levels of serum concentration
it may decrease the levels of serum concentration
it may decrease the levels of serum concentration
it may decrease the levels of serum concentration
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
it may decrease the levels of serum concentration
Actions and Spectrum:
Actions:
Spectrum:
Adverse drug reactions:
Frequency not Defined
Angina
arrhythmias
myocardial infarction
QT-interval prolongation
ventricular tachycardia
Eczematoid dermatitis
Increased IOP
Follicular conjunctivitis
Edema
Vascular congestion
Exudate
Black Box Warning:
none
Contraindication / Caution:
Contraindications:
Caution:
Pregnancy warnings:
Pregnancy category: N/A
Breastfeeding warnings:
The release of the drug into the human breastmilk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Hydrocodone acts as a narcotic agonist with analgesic and antitussive effects, helping to relieve pain and suppress cough. Homatropine is an anticholinergic included in a subtherapeutic dose to discourage intentional overdose.
Pharmacodynamics
Hydrocodone works by binding to opioid receptors in the brain and spinal cord, producing pain relief and cough suppression. Homatropine, an anticholinergic, has minimal therapeutic effect at its low dose but is added to deter misuse by causing unpleasant side effects if taken in excess. Together, the combination helps manage cough and moderate pain while reducing the risk of intentional overdose.
Pharmacokinetics
Hydrocodone:
Absorption: Peak levels reached in about 1.3 hours.
Distribution/Duration: Effects last 4–8 hours.
Metabolism: Metabolized mainly in the liver by CYP2D6 through O-demethylation, N-demethylation, and 6-keto reduction.
Excretion: Eliminated mostly in the urine.
Half-life: Approximately 3.3–4.4 hours.
Homatropine:
Duration of action: Around 6 hours.
Excretion: Primarily cleared through the urine.
Give this medication by mouth only, using a precise milliliter measuring device to ensure the correct dose. Do not use a household teaspoon, as it may lead to dosing errors or overdose. If no measuring device is included, ask a pharmacist for an appropriate one and instructions on proper use. After each dose, rinse the measuring device with water.
Patient Information Leaflet
Generic Name: hydrocodone/homatropine
Pronunciation: hy-ko-dan, HYE-droe-KOE-done/hoe-MAT-roe-peen
Why do we use hydrocodone/homatropine?
hydrocodone/homatropine is a combination medication used for the symptomatic relief of cough. Here are the main reasons why hydrocodone/homatropine is used:
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