Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Brisdelle, Pexeva, Paxil CR, Paxil
Synonyms :
paroxetine Â
Class :
Selective serotonin reuptake inhibitors, Antidepressants
Brand Name :
Brisdelle, Pexeva, Paxil CR, Paxil
Synonyms :
paroxetine Â
Class :
Selective serotonin reuptake inhibitors, Antidepressants
Dosage forms and strength Â
Tablet (Immediate release)Â
20 mgÂ
30 mg Â
40 mgÂ
Tablet (controlled release)Â
12.5 mg Â
25 mgÂ
37.5 mgÂ
20
mg
Orally 
every day
and increase up to 20-50 mg/day orally
The Maximum dose for a day is 50 mg
20
mg
orally
every day
and increase up to 20-50 mg/day orally
The Maximum dose for a day is 50 mg
20
mg
orally
every day
and increase up to 20-50 mg/day orally
The Maximum dose for a day is 50 mg
10
mg
Orally 
every day
and increase up to 10-40 mg/day orally
The Maximum dose for a day is 60 mg
Posttraumatic Stress DisorderÂ
20
mg
Tablet
Orally 
every day
may increase by 10 mg Weekly, do not exceed 50 mg a day
Note:
No benefits seen with >20 mg a day
May increase the hypoglycemic effect of each other when combined
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
may have an increased antiplatelet effect when combined with NSAIDs
may increase the serotonergic effect of tricyclic antidepressants
may increase the tachycardic effect of Alpha-/Beta-Agonists
may enhance the concentration of serum when combined with paroxetine
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
May increase the hypoglycemic effect of each other when combined
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
it increases the toxicity of SSRIs
it increases the toxicity of SSRIs
it increases the effect of SSRIs
it increases the effect of SSRIs
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
it may increase the effect of serotonergic agents
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may increase the antiplatelet effect
may increase the antiplatelet effect
may increase the antiplatelet effect
may increase the antiplatelet effect
may increase the antiplatelet effect
it may diminish the metabolism when combined with zuclopenthixol
It may enhance the metabolism when combined with dexamethasone
selective serotonin reuptake inhibitors (A2): they may increase the hypoglycemic effect of blood viscosity reducing agents
selective serotonin reuptake inhibitors (A2): they may increase the hypoglycemic effect of blood viscosity reducing agents
When encainide is used together with paroxetine, this leads to a reduction in the encainide’s metabolism
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
when both drugs are combined, there may be an increase in the serum concentration of paroxetine  
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
It may lead to sedation, respiratory depression, and coma
It may lead to sedation, respiratory depression, and coma
It may lead to sedation, respiratory depression, and coma
may enhance the toxicity of the other through anti coagulation
may increase the antiplatelet effect
may increase the serum concentrations of CYP2D6 inhibitors
may increase the hypoglycemic effect of blood glucose-lowering agents
may increase the toxic effect of antipsychotic agents
may increase the serotonergic effect of Serotonin 5-HT1D Receptor Agonists
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
empagliflozin and linagliptinÂ
may increase the hypoglycaemic effect when combined
may increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
It may enhance the risk of adverse effects when combined with calcium
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
Actions and Spectrum:Â
Paroxetine works by managing serotonin levels in the brain. It works as an antidepressant that helps to prevent neurons from reabsorbing serotonin which leads to increased levels in the synaptic cleft. Â
Frequency Defined  Â
>10%   Â
Asthenia   Â
Constipation  Â
Diarrhea   Â
Dizziness   Â
Nausea   Â
Headache  Â
1-10%   Â
Decreased appetite   Â
Impotence   Â
Nervousness  Â
Anxiety   Â
Frequency Not Defined   Â
Tachycardia  Â
Emotional lability  Â
Hypertension  Â
Weight gain Â
Black Box Warning:Â Â
 None Â
Contraindication/Caution:Â Â
Contraindications Â
Hypersensitivity Â
Cautions Â
Renal impairment Â
CVS disorders Â
Bleeding disorders Â
Clotting disorders Â
Pregnancy Warnings:Â
Pregnancy category: DÂ
Lactation: It crosses into human breast milk is known  Â
Pregnancy categories:Â
Pharmacology:Â Â
They prolong serotonin’s presence between nerve cells and promote increased neurotransmission and communication. Â
Pharmacodynamics:Â Â
The effects on the reuptake of norepinephrine and dopamine are minimal. This specific inhibition of serotonin reuptake distinguishes paroxetine which emphasizes its potent influence on the serotonin neurotransmitter system.Â
Pharmacokinetics:Â Â
Absorption Â
The peak plasma concentration is achieved within 5.2 to 8.1 hours for immediate- release and 6 to 10 hours for controlled-release. Â
Distribution Â
The volume of distribution is 8.7 L/kg.Â
Metabolism Â
It undergoes hepatic metabolism.Â
Elimination and Excretion Â
The drug is excreted in feces and urine.Â
Administration:Â Â
It is taken orally in the form of tablets.Â
Patient Information Leaflet    Â
Generic Name: paroxetine Â
Why do we use paroxetine? Â
Paroxetine belongs is used to treat obsessive-compulsive disorder, depression, Major Depressive Disorder, Panic Disorder, Post-traumatic stress disorder, Generalized Anxiety Disorder, and Premenstrual Dysphoric Disorder Â
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