Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Tobrex
(United States) [Available]Synonyms :
Class :
Antibiotics & Aminoglycoside
Brand Name :
Tobrex
(United States) [Available]Synonyms :
Class :
Antibiotics & Aminoglycoside
Dosage forms & StrengthsÂ
Solution, Ophthalmic:Â
3.5 g (0.3%)Â Â
Ointment, Ophthalmic:Â
0.3% (5 ml)Â Â
Mild to moderate infections:
Ointment: Apply half-inch to affected areas 2 to 3 times daily every 8 to 12 hrs
Solution: 1 to 2 drops in affected eyes every 4 hrs
Severe infections:
Ointment: Apply half-inch to affected areas 2 to 3 times daily every 3 to 4 hrs
Solution: 1 to 2 drops in affected eyes every 12hrs, for infection associated with pseudomonas aeruginosa every 5 to 30 minutes (depends on the symptoms)
No dosage adjustment was described for renal/hepatic impairment
Dosage forms & StrengthsÂ
Solution, Ophthalmic:Â
3.5 g (0.3%)Â Â
Ointment, Ophthalmic:Â
0.3% (5 ml)Â Â
Refer to adult dosingÂ
lansoprazole, amoxicillin, and clarithromycin
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
amoxicillin and clavulanate potassium
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the serum concentration of pencillins
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
they increase the effect of hypocalcemia in bisphosphonate derivatives
they increase the effect of hypocalcemia in bisphosphonate derivatives
they increase the effect of hypocalcemia in bisphosphonate derivatives
they increase the effect of hypocalcemia in bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may enhance the hypocalcemic effect
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the nephrotoxic effect of cephalosporins
neomycin/polymyxin B/bacitracin topical
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of aminoglycosides.
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may decrease the excretion of non-steroidal anti-inflammatory drugs
loop diuretics may increase the risk of adverse effect of aminoglycosides
loop diuretics may increase the risk of adverse effect of aminoglycosides
loop diuretics may increase the risk of adverse effect of aminoglycosides
may increase the nephrotoxic effect of aminoglycosides
may increase the nephrotoxic effect of aminoglycosides
may increase the nephrotoxic effect of aminoglycosides
may increase the nephrotoxic effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may decrease the excretion of nonsteroidal anti-inflammatory agents
may have an increased neuromuscular-blocking effect when combined with botulinum toxin-containing products
may enhance the nephrotoxicity of aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may increase the nephrotoxic effect of Amphotericin B
Tobramycin appears to bind to 30S and 50S ribosomal subunits irreversibly that inhibit protein synthesis in sensitive bacteria.Â
It inhibits protein synthesis causes misreading of mRNA that leads to production of nonfunctional or toxic peptides.Â
They easily attach to bacterial membranes including the phospholipids and lipopolysaccharides found in Gram-negative bacteria’s outer membrane.Â
Frequency defined:Â Â
<1%:Â
Hypersensitivity reactionÂ
Eyelid edemaÂ
Eyelid pruritisÂ
Conjunctival erythemaÂ
Postmarketing:Â
Stevens-johnson syndromeÂ
Anaphylaxis Â
None
Contraindication:Â
HypersensitivityÂ
Caution:Â
Sensitivity to topical administered aminoglycosides may occurÂ
Monitor serum aminoglycoside concentrationsÂ
Not for injection into eyeÂ
Concurrency with topical corticosteroidsÂ
Pregnancy consideration: Tobramycin (ophthalmic) can be assigned under pregnancy category N. Ophthalmic solutions show zero to minimal effects on pregnant females.Â
Lactation: No data available regarding the excretion of tobramycin in breast milk. Â
Pregnancy category:Â
Their action interferes with initiation complex formation, translation accuracy, and protein synthesis.Â
The actinomycete Streptomyces tenebrarius is the source of the aminoglycoside antibiotic tobramycin.Â
It is available in form of ophthalmic solution and ophthalmic ointment.Â
For Eye Drops:Â
Tilt head back, pull down the lower eyelid to create a small pocket.Â
Hold the dropper directly over the eye and put drops as per prescription.Â
Never touch the dropper tip to the eye or any surface to avoid contamination.Â
For ointment:Â
Pull down the lower eyelid to form a pocket.Â
Squeeze a 0.5 to 1 inch ribbon of ointment into the conjunctival sac.Â
Close the eye for 1 to 2 minutes and roll the eyeball around gently to distribute the ointment.Â
It is preferable to apply before bed to avoid temporary blurred eyesight.Â
Generic Name: tobramycin (ophthalmic)Â
Why do we use tobramycin (ophthalmic)? Â
Tobramycin is indicated in treatment of eye Infection.Â
It is used to treat or prevent bacterial infections of the external parts of the eye.Â
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