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November 16, 2025
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Brand Name :
N/A
Synonyms :
bromperidol
Class :
Antipsychotic Agents
Brand Name :
N/A
Synonyms :
bromperidol
Class :
Antipsychotic Agents
Dosage Forms & Strengths
Tablet
15mg
Injection
300mg
Administer 1 to 15mg every day orally. Do not exceed 50mg. OR
Administer up to 300 mg every 4 weeks through deep intramuscular injection
Administer 1 to 15mg every day orally. Do not exceed 50mg. OR
Administer up to 300 mg every 4 weeks through deep intramuscular injection
Dosage Forms & Strengths
Safety and efficacy are not established
Refer adult dosing
may increase the central nervous system depressant effect
acrivastine and pseudoephedrine
may increase the CNS depressant effect of CNS depressants
may decrease the hypotensive effect of Blood Pressure Lowering Agents
it decreases the effect of hypotension on blood-lowering agents
it decreases the effect of hypotension on blood-lowering agents
it decreases the effect of hypotension on blood-lowering agents
it decreases the effect of hypotension on blood-lowering agents
it decreases the effect of hypotension on blood-lowering agents
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may increase the hypotensive effect of anti-hypertensive agents
may increase the hypotensive effect of anti-hypertensive agents
may increase the hypotensive effect of anti-hypertensive agents
may increase the hypotensive effect of anti-hypertensive agents
may increase the hypotensive effect of anti-hypertensive agents
may increase the CNS depressant effect of bromperidol
may increase the CNS depressant effect of bromperidol
may increase the CNS depressant effect of bromperidol
may decrease the hypotensive effect when combined with anti-hypertensive agents
may decrease the hypotensive effect when combined with anti-hypertensive agents
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
bromperidol: they may increase the CNS depressant effect of CNS Depressants
bromperidol: they may increase the CNS depressant effect of CNS Depressants
bromperidol: they may increase the CNS depressant effect of CNS Depressants
may have an increasingly adverse effect when combined with immunosuppressants
may have an increasingly adverse effect when combined with immunosuppressants
may have an increasingly adverse effect when combined with immunosuppressants
may have an increasingly adverse effect when combined with immunosuppressants
may have an increasingly adverse effect when combined with immunosuppressants
it decreases the efficacy of blood pressure-lowering agents
bromeperidol: they may decrease the hypotensive effect of blood viscosity reducing agents
bromeperidol: they may decrease the hypotensive effect of blood viscosity reducing agents
it reduces the efficacy of blood pressure-lowering agents
it reduces the efficacy of blood pressure-lowering agents
it reduces the efficacy of blood pressure-lowering agents
it reduces the efficacy of blood pressure-lowering agents
it reduces the efficacy of blood pressure-lowering agents
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the hypotensive effect of anti-hypertensives
may increase the CNS depressant effect of CNS depressants
may increase the hypotensive effect of blood pressure lowering agents
lisinopril/hydrochlorothiazide
may increase the hypotensive effect of blood pressure lowering agents
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the hypotensive effect of blood pressure-lowering agents
may decrease the hypotensive effect of Blood Pressure Lowering Agents
may diminish the hypotensive effect of Blood Pressure Lowering Agents
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
acetaminophen/doxylamine/dextromethorphan
may increase the CNS depressant effect CNS Depressants
may decrease the hypotensive effect of Blood Pressure Lowering Agents
may have an increased CNS depression when combined with bromperidol
antacids reduce the systemic absorption of bromeperidol
antacids reduce the systemic absorption of bromeperidol
antacids reduce the systemic absorption of bromeperidol
antacids reduce the systemic absorption of bromeperidol
antacids reduce the systemic absorption of bromeperidol
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
bromeperidol increases the toxicity of anticoagulants
bromeperidol increases the toxicity of anticoagulants
bromeperidol increases the toxicity of anticoagulants
bromeperidol increases the toxicity of anticoagulants
bromeperidol increases the toxicity of anticoagulants
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
bromeperidol: they may decrease the absorption of antacids:
bromeperidol: they may decrease the absorption of antacids:
bromeperidol: they may decrease the absorption of antacids:
bromeperidol: they may decrease the absorption of antacids:
bromeperidol: they may decrease the absorption of antacids:
bromperidol: it may increase the central nervous system depressant activities of tolperisone
may increase the CNS depressant effect
aluminum hydroxide/magnesium hydroxide
may decrease the absorption of Antacids
Actions and Spectrum:
Bromperidol is an atypical antipsychotic of the butyrophenone class of drugs. It is mainly given to the treatment of psychosis and specifically schizophrenia. Bromperidol works based on its dopamine antagonistic effects on the dopamine D2 receptors in the brain.
Dopamine Receptor Antagonism:
The drug is used in the management of schizophrenia. Its action involves the blockade of central dopamine receptors with a special emphasis on the D-2 receptors.
Dopamine is a chemical which gives a crucial function for brain activity, and it is mood regulator as well.
Thus, bromperidol prevents the impact of increased dopamine activity within the patient’s body and directly targets the primary symptoms of schizophrenia.
Spectrum of Activity:
Bromperidol is primarily utilized in psychoses and schizophrenia treatment.
It assist in the reduction of the conditions like psychosis, schizophrenia and other related disorders that are marked by delusions,hallucinations and thought disorder.
Frequency not defined
Neuroleptic malignant syndrome
CNS effects
Alter temp regulation
GI disturbances
Antimuscarinic symptoms
CV symptoms
Nasal congestion
Black box warning:
None
Contraindications/caution:
Contraindications:
Hypersensitivity
Central Nervous System Depression
CNS Tumors
Cardiovascular Disease
Renal and Hepatic Impairment
Cautions:
Elderly Patients
Patients with Cardiovascular Conditions
Neurological Conditions
Seizure Disorders
Pregnancy/Lactation:
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Pharmacology:
Bromperidol belongs to the category of antipsychotic drugs, the action of which is based on the interaction with the neurotransmitter systems of the brain, specifically the dopamine system.
Pharmacodynamics:
Bromperidol is mainly an anti-psychotic drug that works on the central nervous system via dopamine antagonism and mostly on the D2 receptors. This leads to a reduction of dopamine activity and hence it is beneficial in reducing psychotic disturbances, since psychotic disorders involve over activity of dopamine.
Pharmacokinetics:
Absorption
Bromperidol is given orally or intramuscularly. It is well absorbed from the gastrointestinal tract after oral administration of its products.
Distribution
It is distributed in all parts of the body especially the central nervous system. It crosses the blood brain barrier.
Metabolism
Bromperidol is metabolized mainly through the liver, by the cytochrome P450 enzyme system.
Excretion and Elimination
The major excretory pathway is through the urine. The bromperidol elimination half-life may differ but usually is within 20 to 30 hours.
Administration
Oral administration
The tablets can be taken with or without meals, and they are often taken with a glass of water.
Patient Information Leaflet
Generic Name: bromperidol
Why do we use bromperidol?
Bromperidol is used in the treatment of schizophrenia, a psychosis disorder which manifests itself in unusual thought patterns and behaviours, as well as in emotional dysfunctions. It assists in reducing some of the symptoms like delusions, hallucinations, disorganized thinking as well as social and emotional detachment.
In some instances, bromperidol could be administered in the management of Tourette’s syndrome which is a neurological condition that affects people through involuntary and repetitive movements and known as tics.
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