Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Trilisate ASA combination
Synonyms :
choline magnesium trisalicylate 
Class :
NSAIDs
Brand Name :
Trilisate ASA combination
Synonyms :
choline magnesium trisalicylate 
Class :
NSAIDs
Dosage forms and strengths Â
liquidÂ
500mg/5mLÂ Â
tabletÂ
1000mg Â
750mg Â
500mg Â
Dosage forms and strengthsÂ
liquidÂ
500mg/5mLÂ Â
tabletÂ
1000mg Â
750mg Â
500mg Â
Dosage forms and strengthsÂ
liquidÂ
500mg/5mLÂ Â
tabletÂ
1000mg Â
750mg Â
500mg Â
Salicylates may enhance the risk of adverse effects of Carbonic Anhydrase Inhibitors
Salicylates may enhance the risk of adverse effects of Carbonic Anhydrase Inhibitors
Salicylates may enhance the risk of adverse effects of Carbonic Anhydrase Inhibitors
Salicylates may enhance the risk of adverse effects of Carbonic Anhydrase Inhibitors
Salicylates may enhance the risk of adverse effects of Carbonic Anhydrase Inhibitors
salicylates may increase the adverse effect of corticosteroids
salicylates may increase the adverse effect of corticosteroids
salicylates may increase the adverse effect of corticosteroids
salicylates may increase the adverse effect of corticosteroids
salicylates may increase the adverse effect of corticosteroids
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
May increase the hypoglycemic effect of each other when combined
May increase the hypoglycemic effect of each other when combined
May increase the hypoglycemic effect of each other when combined
May increase the hypoglycemic effect of each other when combined
May increase the hypoglycemic effect of each other when combined
may have an increasingly adverse effect when combined with carbonic anhydrase inhibitors
may have an increasingly adverse effect when combined with carbonic anhydrase inhibitors
may have an increasingly adverse effect when combined with carbonic anhydrase inhibitors
may have an increasingly adverse effect when combined with carbonic anhydrase inhibitors
may have an increasingly adverse effect when combined with carbonic anhydrase inhibitors
NSAIDs may enhance the adverse/toxic effect of Salicylates
NSAIDs may enhance the adverse/toxic effect of Salicylates
NSAIDs may enhance the adverse/toxic effect of Salicylates
NSAIDs may enhance the adverse/toxic effect of Salicylates
NSAIDs may enhance the adverse/toxic effect of Salicylates
may increase the toxic effect of nonsteroidal anti-inflammatory agents
may increase the anticoagulant effect of warfarin
Nonsteroidal Anti-Inflammatory Agents: they may increase the toxic effect of salicylates
Nonsteroidal Anti-Inflammatory Agents: they may increase the toxic effect of salicylates
Nonsteroidal Anti-Inflammatory Agents: they may increase the toxic effect of salicylates
Nonsteroidal Anti-Inflammatory Agents: they may increase the toxic effect of salicylates
Nonsteroidal Anti-Inflammatory Agents: they may increase the toxic effect of salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with dexketoprofen
may have an increasingly adverse effect when combined with salicylates
The therapeutic efficacy of probenecid could be reduced by salicylates
The serum concentration of sulfinpyrazone may be lowered by salicylates
when both drugs are combined, there may be an increase in adverse effects
salicylates may enhance the nephrotoxic effect of ACE Inhibitors
salicylates may enhance the nephrotoxic effect of ACE Inhibitors
salicylates may enhance the nephrotoxic effect of ACE Inhibitors
salicylates may enhance the nephrotoxic effect of ACE Inhibitors
salicylates may enhance the nephrotoxic effect of ACE Inhibitors
may enhance the adverse/toxic effect of thrombolytic agents
salicylates may enhance the anticoagulant effect of anticoagulants
salicylates may enhance the anticoagulant effect of anticoagulants
salicylates may enhance the anticoagulant effect of anticoagulants
salicylates may enhance the anticoagulant effect of anticoagulants
salicylates may enhance the anticoagulant effect of anticoagulants
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the adverse effect of carbonic anhydrase inhibitors
may enhance the adverse effect of carbonic anhydrase inhibitors
may enhance the adverse effect of carbonic anhydrase inhibitors
may enhance the adverse effect of carbonic anhydrase inhibitors
may enhance the adverse effect of carbonic anhydrase inhibitors
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
may enhance the adverse effect of corticosteroids
antiplatelet agents increase the toxicity of salicylates
antiplatelet agents increase the toxicity of salicylates
antiplatelet agents increase the toxicity of salicylates
antiplatelet agents increase the toxicity of salicylates
antiplatelet agents increase the toxicity of salicylates
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may increase the risk of adverse effect of thrombolytic agents
salicylates: they may increase the hypoglycemic effect of agents with blood viscosity reducing agents
salicylates: they may increase the hypoglycemic effect of agents with blood viscosity reducing agents
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
It may enhance the risk of adverse reactions when combined with Salicylates
It may enhance the risk of adverse reactions when combined with Salicylates
It may enhance the risk of adverse reactions when combined with Salicylates
It may enhance the risk of adverse reactions when combined with Salicylates
It may enhance the risk of adverse reactions when combined with Salicylates
It may enhance the risk of adverse reactions when combined with Salicylates
It may enhance the risk of adverse reactions when combined with Salicylates
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
It may enhance the risk of adverse effects when combined with Salicylates
may decrease the diuretic effect of loop diuretics
may decrease the diuretic effect of loop diuretics
may decrease the diuretic effect of loop diuretics
choline magnesium trisalicylate leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When choline magnesium trisalicylate is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When choline magnesium trisalicylate is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
salicylates may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
salicylates may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
salicylates may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
salicylates may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
salicylates may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may enhance the adverse/toxic effect of salicylates
may increase the risk of adverse effect of salicylates
may increase the risk of adverse effect of salicylates
may increase the risk of adverse effect of salicylates
may increase the risk of adverse effect of salicylates
may increase the risk of adverse effect of salicylates
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the nephrotoxic effect of ACE inhibitors
may enhance the risk of adverse effect of thrombolytic agents
measles, mumps, rubella and varicella vaccine, liveÂ
may increase the toxic effects of varicella virus containing vaccine
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
may enhance the adverse effect of salicylates
lisinopril/hydrochlorothiazideÂ
may increase the nephrotoxic effect of Angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with salicylates
may have an increasingly adverse effect when combined with ajmaline
may enhance the anticoagulant effect of salicylates
may increase the hypoglycemic effect of blood glucose-lowering agents
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may decrease the therapeutic effect of hyaluronidase
The serum concentration of salicylates may be increased by ammonium chloride
The serum concentration of salicylates may be increased by potassium phosphate
It may increase the anticoagulant effect when combined with Salicylates (Topical)
empagliflozin and linagliptinÂ
may increase the hypoglycaemic effect when combined
may increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may increase the Glucose-lowering effect of Agents with Blood Glucose Lowering Effects
choline magnesium trisalicylate might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
when both drugs are combined, there may be an increased effect of choline magnesium trisalicylate by acidic drug competition for renal tubular clearance  
salicylates may also lead to an elevation in the concentration of methotrexate
Actions and SpectrumÂ
Action:Â
Analgesic: The drug helps to relieve pain by inhibiting the production of prostaglandins, which are chemical messengers involved in pain signaling.Â
Anti-inflammatory: The medication effectively reduces inflammation by inhibiting the secretion of inflammatory mediators, including prostaglandins and leukotrienes. Â
Antipyretic: The drug can help reduce fever by acting on the hypothalamic heat-regulating centers in the brain.Â
Spectrum:Â
Musculoskeletal conditions: The drug is often used to alleviate pain and inflammation associated with various musculoskeletal conditions, such as arthritis, osteoarthritis, rheumatoid arthritis, gout, and fibromyalgia. Â
Pain management: It can be employed for the relief of mild to moderate pain, including headaches, toothaches, menstrual pain, back pain, and muscle aches. Â
Fever reduction: The drug can help lower elevated body temperature in cases of fever.Â
Frequency not defined Â
BronchospasmÂ
Renal damageÂ
bleeding /GI pain/ulcerationÂ
HepatotoxicityÂ
CNS alterationÂ
AngioedemaÂ
Tinnitus, hearing lossÂ
Premature hemolysisÂ
Pulmonary edema (salicylate-induced/noncardiogenic)Â
Dermatologic problems, urticariaÂ
Black Box Warning:Â
None Â
Contraindication/Caution:Â Â
Hypersensitivity or allergy: Individuals who are allergic to salicylates or any components of choline magnesium trisalicylate should not use this medication. Allergic reactions may include hives, itching, swelling, difficulty breathing, or rash.Â
Asthma and nasal polyps: The drug should be avoided in individuals with a history of asthma or nasal polyps. salicylates may trigger bronchospasms and worsen asthma symptoms. Â
Bleeding disorders: The drug can interfere with blood clotting, and therefore, it should be used with caution or avoided in individuals with bleeding disorders.Â
Children and teenagers: The use of this drug in children and teenagers with viral infections (such as chickenpox or flu-like symptoms) is contraindicated due to the association with Reye’s syndrome, a rare but potentially life-threatening condition.Â
Kidney disease: The drug contains magnesium, and individuals with severe kidney disease or impaired renal function should avoid this medication due to the potential for magnesium accumulation.Â
Pregnancy warnings:    Â
Pregnancy category: CÂ
Lactation: Excreted into human milk is knownÂ
Pregnancy Categories:        Â
Pharmacology:Â Â
The drug belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). It is a combination of choline salicylate and magnesium salicylate, which are both salicylate derivatives.Â
Pharmacodynamics:Â
The drug exerts its pharmacological effects primarily through its active ingredient, salicylate. salicylates are thought to inhibit the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. This inhibition leads to anti-inflammatory, analgesic (pain-relieving), and antipyretic (fever-reducing) effects.Â
Pharmacokinetics:Â
AbsorptionÂ
The drug is administered orally, and its absorption occurs predominantly in the stomach and small intestine. Â
DistributionÂ
The drug is distributed throughout the body via the bloodstream. NSAIDs, in general, have a moderate degree of protein binding, with choline magnesium trisalicylate having a binding affinity to albumin.Â
MetabolismÂ
The metabolism of drug take place in the liver. It undergoes hydrolysis to release salicylate, which is the active form of the drug. Salicylate metabolism involves conjugation with glycine or glucuronic acid in the liver, and the resulting metabolites are eliminated through the kidneys.Â
Excretion and EliminationÂ
The elimination half-life of this drug is around 6 to 9 hours. The primary route of elimination is through the kidneys, primarily as metabolites of salicylate. Some unchanged drug may also be excreted in the urine.Â
Administration: Â
The drug is typically taken orally in the form of tablets or capsules. Â
The frequency and timing of doses may vary depending on the specific instructions given by your healthcare provider.
Patient information leafletÂ
Generic Name: choline magnesium trisalicylateÂ
Why do we use choline magnesium trisalicylate? Â
Pain relief: The drug is used to relieve pain for conditions like headaches, toothaches, muscle aches, menstrual cramps, and arthritis.Â
Inflammation: It is effective in reducing inflammation associated with conditions like rheumatoid arthritis, osteoarthritis, and other inflammatory joint disorders.Â
Fever reduction: The drug can help reduce fever in cases where an inflammatory process is causing the elevated body temperature.Â
Gout management: It may be used as part of the treatment for gout, The drug can help alleviate pain and reduce inflammation during gout flare-ups.Â
Dental pain relief: Due to its analgesic properties, The drug can provide temporary relief from dental pain and discomfort until dental treatment can be received.Â
Postoperative pain: It may be used to manage mild to moderate postoperative pain, providing relief for patients after surgical procedures.Â
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