The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Nu-Mag
(United States) [Available] ,Slow Magnesium/Calcium
(United States) [Available] ,Slow-Mag
(United States) [Available] ,SlowMag Mg Muscle/Heart
(United States) [Pending for FDA approval]Synonyms :
magnesium chloride
Class :
Minerals and electrolytes
Brand Name :
Nu-Mag
(United States) [Available] ,Slow Magnesium/Calcium
(United States) [Available] ,Slow-Mag
(United States) [Available] ,SlowMag Mg Muscle/Heart
(United States) [Pending for FDA approval]Synonyms :
magnesium chloride
Class :
Minerals and electrolytes
Dosage Forms & StrengthsÂ
Tablet extended releaseÂ
535mg (64mg elemental)Â
injectable solutionÂ
200mg/mLÂ
Males: 400-420 mg orally every Day
18-30 (Females)
310 mg orally every Day
Pregnancy: 350 mg orally every Day
Lactation: 310 mg orally every Day
>30 years (Females)
320mg per day
Lactating women: 320 mg/day
Pregnant women: 360 mg/day
4 gm (in 250 mL D5W) Intravenous infusion; not more than 3 mL/min
Usual Range: 1- 40 g Intravenous every Day
Dosage Forms & StrengthsÂ
Tablet extended releaseÂ
535mg (64mg elemental)Â
injectable solutionÂ
200mg/mLÂ
RDA:
13-18 years: men: 410 mg/day;
women: 360 mg/day;
Lactating women: 360 mg/day;
Pregnant women: 400 mg/day
8-13 years: 240 mg/day
3-8 years: 130 mg/day
1-3 years: 80 mg/day
6-12 months: 75 mg/day
<6 months: 30 mg/day
RDA:
13-18 years: men: 410 mg/day;
women: 360 mg/day;
Lactating women: 360 mg/day;
Pregnant women: 400 mg/day
8-13 years: 240 mg/day
3-8 years: 130 mg/day
1-3 years: 80 mg/day
6-12 months: 75 mg/day
<6 months: 30 mg/day
RDA:
13-18 years: men: 410 mg/day;
women: 360 mg/day;
Lactating women: 360 mg/day;
Pregnant women: 400 mg/day
8-13 years: 240 mg/day
3-8 years: 130 mg/day
1-3 years: 80 mg/day
6-12 months: 75 mg/day
<6 months: 30 mg/day
Refer to the adult dosing regimenÂ
bismuth subcitrate, metronidazole and tetracycline
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
tetraferric tricitrate decahydrate
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
bismuth subcitrate, metronidazole and tetracycline
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may reduce the levels of serum concentration of multivitamins
may reduce the level of serum concentration of quinolones
may reduce the level of serum concentration of quinolones
may diminish the absorption when combined with tetracyclines
magnesium salts: they may diminish the bioavailability of corticosteroids A1
magnesium salts: they may diminish the bioavailability of corticosteroids A1
magnesium salts: they may diminish the bioavailability of corticosteroids A1
magnesium salts: they may diminish the bioavailability of corticosteroids A1
magnesium salts: they may diminish the bioavailability of corticosteroids A1
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J3
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the bioavailability of corticosteroids J4
magnesium salts: they may diminish the absorption of phosphate binders
magnesium Salts may decrease the serum concentration of Dolutegravir
magnesium Salts may decrease the serum concentration of quinolones
magnesium Salts may decrease the serum concentration of quinolones
may diminish the serum concentration of quinolones
may have an increased hypermagnesemic effect when combined with magnesium salts
may have a decreased absorption when combined with alpha-lipoic acid
may increase the serum concentration when combined with magnesium salts
may have a decreased serum concentration when combined with dolutegravir
may have a decreased serum concentration when combined with quinolones
may have a decreased serum concentration when combined with quinolones
bismuth subcitrate, metronidazole and tetracycline
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
acalabrutinib: they may diminish the serum concentration of magnesium salts
alfacalcidol: they may enhance the serum concentration of magnesium salts
atazanavir: they may diminish the absorption of magnesium salts
cefuroxime: they may diminish the serum concentration of magnesium salts
chloroquine: they may diminish the serum concentration of magnesium salts
dabigatran: they may diminish the serum concentration of magnesium salts
delavirdine: they may diminish the serum concentration of magnesium salts
eltrombopag: they may increase the hypermagnesemic effect of magnesium salts
fosinopril: they may increase the CNS depressant effect of magnesium salts
infigratinib: they may diminish serum concentrations of magnesium salts
it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
it may inhibit the GI absorption of doxycycline (provide 2 hours difference between both drugs)
may diminish the serum concentration when combined with raltegravir
may have an increased CNS depressant effect when combined with gabapentin
may have a decreased serum concentration when combined with levothyroxine
may have a decreased serum concentration when combined with fluoride/multivitamins (with ADE)
may decrease the serum concentration of Polyvalent Cation Containing Products
levonorgestrel: they may diminish the serum concentration of magnesium salts
magnesium salts may increase the effect of neuromuscular-blocking agents
magnesium salts may increase the effect of neuromuscular-blocking agents
magnesium salts may increase the effect of neuromuscular-blocking agents
magnesium salts may increase the effect of neuromuscular-blocking agents
magnesium salts may increase the effect of neuromuscular-blocking agents
may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may increase the effect of neuromuscular-blocking agents
may reduce the rate of absorption of tetracyclines
may reduce the rate of absorption of tetracyclines
may reduce the rate of absorption of tetracyclines
It may enhance the levels when combined with sodium polystyrene sulfonate by diminishing renal clearance
it may enhance the risk of side effects when combined with misoprostol
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents
may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents
may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents
may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents
may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the effects of the drug by GI absorption inhibition
Actions and spectrum:Â
magnesium chloride is used to treat or prevent low magnesium levels in the blood, known as hypomagnesemia. magnesium chloride works by providing the body with essential magnesium, which is involved in many important bodily processes, such as maintaining normal nerve and muscle function, regulating heart rhythm, and building strong bones.
magnesium chloride is also used in some medical procedures, such as as a cathartic to empty the bowels before surgery or to treat cardiac arrest caused by magnesium deficiency. Additionally, magnesium chloride has some topical uses, such as in foot soaks to relieve muscle cramps or as a mouthwash to treat oral health problems.Â
Frequency not definedÂ
Respiratory depressionÂ
FlushingÂ
StuporÂ
HypothermiaÂ
HypotensionÂ
SweatingÂ
Black Box Warning:Â
There are no black box warnings associated with the use of magnesium chloride.Â
Contraindication/Caution:Â
Contraindication:Â
magnesium chloride is contraindicated in individuals with a known hypersensitivity to magnesium chloride or any of its components. It is also contraindicated in patients with severe renal impairment or renal failure, as magnesium excretion is reduced in these patients, leading to magnesium toxicity.
Patients with heart block or myocardial damage should also use magnesium chloride with caution. Additionally, magnesium chloride is contraindicated in patients with bowel obstruction or perforation, as it may exacerbate these conditions. Â
Caution:Â
Comorbidities:Â
Pregnancy consideration: pregnancy category AÂ
Lactation: Magnesium supplements, including magnesium chloride, may be recommended to pregnant and breastfeeding women who are not getting enough magnesium from their diet. Â
Pregnancy category:Â
Pharmacology:Â
magnesium chloride is an inorganic salt that is used as a magnesium supplement or electrolyte replenisher. Magnesium plays an important role in several biological functions in the body. magnesium chloride acts as a magnesium source to maintain the normal levels of magnesium in the body.
It is rapidly absorbed and metabolized in the liver and excreted in urine. magnesium chloride can also act as an osmotic laxative and has a mild antacid effect due to its alkaline nature. Â
Pharmacodynamics:Â
Pharmacokinetics:Â
AbsorptionÂ
When administered intravenously, magnesium chloride is rapidly and completely absorbed into the systemic circulation. After intramuscular injection, the absorption rate is slower and may vary based on the site of injection.Â
DistributionÂ
magnesium ions are widely distributed throughout the body, with the highest concentrations found in bone and muscle tissues. Magnesium crosses the blood-brain barrier and placenta, but it does not accumulate in these tissues.Â
MetabolismÂ
magnesium chloride is not metabolized in the body.Â
Elimination and excretionÂ
magnesium is primarily excreted in the urine, with a small amount eliminated in the feces. The rate of excretion is influenced by the serum concentration of magnesium, with higher serum levels leading to increased renal clearance.Â
Administration:Â
magnesium chloride is available in different forms, including oral tablets and capsules, intravenous (IV) injection, and topical formulations. The route of administration and dosage may vary depending on the indication for which it is being used.Â
Oral magnesium chloride supplements are usually taken with a glass of water, and it is recommended to take them after meals to minimize the risk of gastrointestinal side effects. The dosage and frequency of oral magnesium chloride supplements depend on the age, health condition, and other factors of the patient.Â
magnesium chloride injections are usually given by a healthcare professional in a hospital or clinic setting. The duration and dosage of treatment may vary depending on the patient’s condition and response to treatment.Â
Patient information leafletÂ
Generic Name: magnesium chlorideÂ
Pronounced: [ mag-NEE-see-um-KLOE-ride]Â Â
Why do we use magnesium chloride?Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
