magnesium citrate

Brand Name :

Citroma, Citroma Lemon,nCitrate of Magnesia

Synonyms :

magnesium citrate

Class :

Laxative

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Actions and Spectrum: 

  • magnesium citrate is a medication used to relieve constipation and promote bowel movements. Its mechanism of action involves attracting water into the colon, which softens the stool and increases its volume. This helps to stimulate bowel movements and alleviate constipation. 
  • magnesium citrate increases the osmotic pressure in the intestines, attracting water into the colon and softening the stool. This increased water content in the colon stimulates peristalsis (the contractions of the intestinal muscles that move stool through the digestive tract), helping to promote bowel movements. 
  • In addition to its use as a laxative, magnesium citrate is sometimes used to treat conditions such as heartburn, indigestion, and acid reflux. It can help to neutralize stomach acid and reduce the symptoms of these conditions. 
  • magnesium citrate has a broad spectrum of activity, effectively treating constipation in people of all ages and backgrounds. 

DRUG INTERACTION

magnesium citrate

&

  • Pembrolizumab / Berahyaluronidase
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  • carnosine
  • alverine citrate/simeticone
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  • urea/hydrocortisone
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  • povidone-iodine (ophthalmic)
  • pheniramine
  • hydrocortisone rectal
  • chloroxylenol/pramoxine/zinc acetate
  • chloroxylenol/pramoxine
  • dextrose/sucrose/vitamin C/zinc sulphate
  • furazolidone/metronidazole/dicyclomine
  • ergocalciferol (vitamin D2)
  • benoxaprofen (discontinued)
  • teicoplanin
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  • chromic chloride / iron (ii) chloride tetrahydrate / potassium iodide / manganese chloride / sodium fluoride / sodium selenite pentahydrate / sodium molybdate dihydrate / zinc chloride/ cupric chloride
  • bufylline
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  • typhoid polysaccharide vaccine
  • sodium phosphate
  • human papillomavirus vaccine, nonavalent
  • peanut immunotherapy epicutaneous (FDA approval pending)
  • cromolyn sodium, intranasal
  • red blood cells(Blood component)
  • oral mucoadhesive
  • clindamycin vaginal
  • whole blood (Blood Component)
  • fibrinogen/thrombin
  • levothyroxine/liothyronine
  • ipratropium intranasal
  • metronidazole vaginal
  • cyamemazine
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  • emylcamate
  • methionine
  • amino acids and electrolytes in dextrose with calcium
  • slippery elm
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  • chlormidazole
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  • diatrizoic acid
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  • ethamsylate
  • flupirtine
  • imidurea
  • sodium glycolate
  • feracrylum
  • ethacridine
  • furazolidone/metronidazole
  • ozagrel hydrochloride
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  • l-glutamic acid /vitamin B complex
  • etizolam
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  • ethoheptazine citrate
  • etophylline and theophylline
  • etophylline
  • finger millet
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  • dichloroxylenol
  • pneumococcal 7-valent vaccine
  • diclofenac and metaxalone
  • dipivefrin ophthalmic
  • enbucrilate
  • potassium citrate and citric acid
  • potassium gluconate
  • aclarubicin
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  • adrenochrome monosemicarbazone
  • selenium sulfide topical
  • sertaconazole
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  • amsacrine
  • amylmetacresol
  • sulfonated phenolics in aqueous solution
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  • raltitrexed
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  • acebrophylline
  • clonazepam/escitalopram oxalate
  • allylestrenol
  • andrographolide
  • artemotil
  • technetium Tc-99m sestamibi
  • rubidium Rb-82
  • somapacitan
  • sodium sulfate, magnesium sulfate and potassium sulfate
  • almitrine
  • gramicidin
  • nikethamide
  • technetium Tc-99m sodium pertechnetate
  • betiatide
  • prilocaine/epinephrine
  • amlexanox
  • acetaminophen/salicylamide/phenyltoloxamine
  • neomycin topical
  • zilucoplan
  • antazoline and xylometazoline
  • toripalimab
  • iron isomaltoside
  • meningococcal A C Y and W polysaccharide tetanus toxoid conjugate vaccine
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • tetradecyl Sulfuric Acid
  • benzoyl peroxide, clindamycin phosphate, adapalene
  • ethylephedrine
  • actarit
  • pyrantel tartrate
  • tenofovir disoproxil fumarate or tenofovir DF
  • melitracen
  • amitriptylinoxide(Phase 4 Clinical Trials)
  • threonine
  • ditiocarb zinc
  • epicriptine
  • levallorphan
  • kinetin
  • laurocapram
  • pentagastrin
  • parthenolide
  • nicoboxil
  • protionamide
  • prulifloxacin
  • proscillaridin
  • tizanidine and rofecoxib
  • tolnaftate, gentamicin, chinoform and betamethasone valerate
  • pine bark extract
  • pipenzolate methylbromide
  • bephenium hydroxynaphthoate
  • niclosamide
  • pyrvinium
  • pipenzolate methylbromide/phenobarbitone
  • piracetam/ginkgo biloba/vinpocetine
  • benzyl benzoate/disulfiram
  • benzyl benzoate
  • loperamide/simethicone
  • piroctone olamine
  • sodium fusidate
  • piroxicam topical/capsaicin/menthol/methyl salicylate
  • sodium metabisulfite
  • sodium lauryl sulfate
  • taspoglutide
  • glyclopyramide
  • tolnaftate, gentamicin, iodochlorohydroxyquinoline, chlorocresol, betamethasone valerate
  • serratiopeptidase
  • sodium antimony gluconate
  • triamterene / benzthiazide
  • tribenoside / lidocaine
  • triclocarban
  • triprolidine/dextromethorphan  
  • vitamins/minerals/omega-3 Fatty acids
  • soyabean oil
  • sucralfate/oxethazaine
  • sucralfate/tinidazole/povidone iodine
  • sodium cromoglycate
  • aloe vera/liquid paraffin/white soft paraffin
  • aloe vera/jojoba oil/vitamin E
  • allantoin/triclosan/vitamin e/zinc oxide
  • alpha-Lipoic acid/minerals/multivitamins
  • alprazolam/paracetamol
  • alprazolam/melatonin
  • azithromycin/ambroxol
  • atorvastatin/clopidogrel/aspirin
  • aceclofenac, paracetamol and serratiopeptidase
  • alfacalcidol, vitamin B-complex, minerals and antioxidants
  • alpha- lipoic acid, vitamin b complex and vitamin c
  • alpha-galactosidase and simethicone
  • alpha-galactosidase, amylase, proteases, lipase and lactase
  • amikacin and cefepime
  • aminophylline, ephedrine and phenobarbitone
  • artesunate, sulphadoxine and pyrimethamine
  • finasteride/tamsulosin
  • flavoxate/ofloxacin
  • fenofibrate/metformin
  • lignocaine, hydrocortisone topical and allantoin
  • linoleic acid and sodium lactate
  • troxerutin
  • meclizine/nicotinic acid
  • mecobalamin/ginkgo Biloba
  • spirulina
  • loperamide and furazolidone
  • ketoconazole/cetrimide
  • ketoconazole/zinc pyrithione
  • lercanidipine/atenolol
  • levocetirizine/montelukast/ambroxol
  • levarterenol
  • levocetirizine/phenylpropanolamine 
  • indapamide/amlodipine
  • itopride/methyl polysiloxane
  • mebendazole/levamisole
  • eberconazole/mometasone
  • gliclazide/metformin/pioglitazone
  • fluconazole/tinidazole
  • haemocoagulase
  • halometasone
  • hesperidin
  • imipramine/chlordiazepoxide
  • idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
  • mecobalamin and piracetam
  • mesterolone
  • mosapride and pantoprazole
  • atorvastatin, co enzyme q10, vitamin e, zinc, and selenium
  • azithromycin and benzalkonium chloride
  • beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12
  • alpha-galactosidase
  • aloe vera gel/vitamin e/lactic acid
  • aloe vera gel/jojoba/vitamin e/glycerine
  • famotidine and domperidone
  • faropenem medoxomil
  • nedosiran
  • fluconazole/ornidazole/azithromycin
  • ebastine/montelukast
  • eberconazole
  • dienogest/estradiol valerate
  • ambroxol/salbutamol
  • benzoic acid/salicylic acid/ichthammol/ triamcinolone acetonide
  • desloratadine/ambroxol
  • dexibuprofen/paracetamol
  • atorvastatin/ramipril
  • diastase
  • diastase and simethicone
  • diazepam and propranolol
  • dexrabeprazole / domperidone
  • dexrabeprazole
  • dexketoprofen /paracetamol
  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • Trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • Elamipretide
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • Methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-hydroxytryptophan (5-htp)
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine, live
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
magnesium citrate + 

Severity : Contraindicated
acalabrutinib: they may enhance the serum concentration of magnesium salts

bismuth subcitrate, metronidazole and tetracycline

magnesium salts may decrease the absorption of tetracyclines

demeclocycline

magnesium salts may decrease the absorption of tetracyclines

omadacycline

magnesium salts may decrease the absorption of tetracyclines

demeclocycline hydrochloride

magnesium salts may decrease the absorption of tetracyclines

doxycycline

magnesium salts may decrease the absorption of tetracyclines

alpha-lipoic acid 

may enhance the serum concentration of magnesium salts

ferric sulfate

may have a decreased serum concentration when combined with phosphate supplements

lanthanum carbonate

may have a decreased serum concentration when combined with phosphate supplements

sevelamer

may have a decreased serum concentration when combined with phosphate supplements

tetraferric tricitrate decahydrate

may have a decreased serum concentration when combined with phosphate supplements

aluminum hydroxide

may have a decreased serum concentration when combined with phosphate supplements

bismuth subcitrate, metronidazole and tetracycline

may have a decreased absorption when combined with tetracyclines

demeclocycline

may have a decreased absorption when combined with tetracyclines

omadacycline

may have a decreased absorption when combined with tetracyclines

demeclocycline hydrochloride

may have a decreased absorption when combined with tetracyclines

doxycycline

may have a decreased absorption when combined with tetracyclines

l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine

may reduce the levels of serum concentration of multivitamins

hydroxychloroquine

may reduce the level of serum concentration of quinolones

sparfloxacin

may reduce the level of serum concentration of quinolones

minocycline

may diminish the absorption when combined with tetracyclines

betamethasone (systemic)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

budesonide (oral inhalation)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

budesonide intranasal

magnesium salts: they may diminish the bioavailability of corticosteroids A1

budesonide (Topical)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

beclomethasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

beclomethasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J3

fluticasone (topical)

magnesium salts: they may diminish the bioavailability of corticosteroids J3

beclomethasone dipropionate

magnesium salts: they may diminish the bioavailability of corticosteroids J3

fluticasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J3

beclomethasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J4

fluticasone (topical)

magnesium salts: they may diminish the bioavailability of corticosteroids J4

beclomethasone dipropionate

magnesium salts: they may diminish the bioavailability of corticosteroids J4

fluticasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J4

calcium polycarbophil

magnesium salts: they may diminish the absorption of phosphate binders

dolutegravir

magnesium Salts may decrease the serum concentration of Dolutegravir

hydroxychloroquine

magnesium Salts may decrease the serum concentration of quinolones

sparfloxacin

magnesium Salts may decrease the serum concentration of quinolones

gemifloxacin 

may diminish the serum concentration of quinolones

doxercalciferol 

may have an increased hypermagnesemic effect when combined with magnesium salts

alpha-lipoic acid 

may have a decreased absorption when combined with alpha-lipoic acid

calcitriol 

may increase the serum concentration when combined with magnesium salts

dolutegravir 

may have a decreased serum concentration when combined with dolutegravir

hydroxychloroquine

may have a decreased serum concentration when combined with quinolones

sparfloxacin

may have a decreased serum concentration when combined with quinolones

bismuth subcitrate, metronidazole and tetracycline

may diminish the absorption when combined with tetracyclines

demeclocycline

may diminish the absorption when combined with tetracyclines

omadacycline

may diminish the absorption when combined with tetracyclines

demeclocycline hydrochloride

may diminish the absorption when combined with tetracyclines

minocycline

may diminish the absorption when combined with tetracyclines

acalabrutinib 

acalabrutinib: they may diminish the serum concentration of magnesium salts

alfacalcidol 

alfacalcidol: they may enhance the serum concentration of magnesium salts

acalabrutinib: they may enhance the serum concentration of magnesium salts

atazanavir 

atazanavir: they may diminish the absorption of magnesium salts

cefuroxime 

cefuroxime: they may diminish the serum concentration of magnesium salts

chloroquine 

chloroquine: they may diminish the serum concentration of magnesium salts

dabigatran 

dabigatran: they may diminish the serum concentration of magnesium salts

delavirdine 

delavirdine: they may diminish the serum concentration of magnesium salts

eltrombopag 

eltrombopag: they may increase the hypermagnesemic effect of magnesium salts

fosinopril 

fosinopril: they may increase the CNS depressant effect of magnesium salts

infigratinib 

infigratinib: they may diminish serum concentrations of magnesium salts

raltegravir 

may diminish the serum concentration of magnesium salts

bismuth subcitrate, metronidazole and tetracycline

may diminish the absorption of magnesium salts

demeclocycline

may diminish the absorption of magnesium salts

omadacycline

may diminish the absorption of magnesium salts

demeclocycline hydrochloride

may diminish the absorption of magnesium salts

minocycline

may diminish the absorption of magnesium salts

hydroxychloroquine

may diminish the serum concentration of magnesium salts

sparfloxacin

may diminish the serum concentration of magnesium salts

aluminum hydroxide

may diminish the serum concentration of magnesium salts

calcium polycarbophil

may diminish the serum concentration of magnesium salts

ferric sulfate

may diminish the serum concentration of magnesium salts

lanthanum carbonate

may diminish the serum concentration of magnesium salts

sevelamer

may diminish the serum concentration of magnesium salts

l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine

may diminish the serum concentration of magnesium salts

etidronate

may diminish the serum concentration of polyvalent cation-containing products

zoledronic acid

may diminish the serum concentration of polyvalent cation-containing products

alendronic acid

may diminish the serum concentration of polyvalent cation-containing products

ibandronate

may diminish the serum concentration of polyvalent cation-containing products

pamidronic acid

may diminish the serum concentration of polyvalent cation-containing products

demeclocycline

it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)

doxycycline

it may inhibit the GI absorption of doxycycline (provide 2 hours difference between both drugs)

raltegravir 

may diminish the serum concentration when combined with raltegravir

gabapentin 

may have an increased CNS depressant effect when combined with gabapentin

levothyroxine 

may have a decreased serum concentration when combined with levothyroxine

multivitamins 

may have a decreased serum concentration when combined with fluoride/multivitamins (with ADE)

magnesium glucoheptonate 

may decrease the serum concentration of Polyvalent Cation Containing Products

levonorgestrel 

levonorgestrel: they may diminish the serum concentration of magnesium salts

botulinum toxin

magnesium salts may increase the effect of neuromuscular-blocking agents

abobotulinumtoxinA

magnesium salts may increase the effect of neuromuscular-blocking agents

rimabotulinumtoxinB

magnesium salts may increase the effect of neuromuscular-blocking agents

daxibotulinumtoxinA

magnesium salts may increase the effect of neuromuscular-blocking agents

prabotulinumtoxinA

magnesium salts may increase the effect of neuromuscular-blocking agents

pancuronium

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

botulinum toxin

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

abobotulinumtoxinA

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

rimabotulinumtoxinB

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

daxibotulinumtoxinA

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

pancuronium

may increase the neuromuscular-blocking effect of magnesium Salts

botulinum toxin

may increase the neuromuscular-blocking effect of magnesium Salts

abobotulinumtoxinA

may increase the neuromuscular-blocking effect of magnesium Salts

rimabotulinumtoxinB

may increase the neuromuscular-blocking effect of magnesium Salts

daxibotulinumtoxinA

may increase the neuromuscular-blocking effect of magnesium Salts

pancuronium

may increase the effect of neuromuscular-blocking agents

tetracycline

may reduce the rate of absorption of tetracyclines

doxycycline

may reduce the rate of absorption of tetracyclines

minocycline

may reduce the rate of absorption of tetracyclines

sodium polystyrene sulfonate 

It may enhance the levels when combined with sodium polystyrene sulfonate by diminishing renal clearance

vitamin d 

It may enhance the effects when combined with vitamin D

misoprostol 

it may enhance the risk of side effects when combined with misoprostol

diphenoxylate/atropine

may have an increased CNS depressant effect when combined with CNS depressants

phenobarbital

may have an increased CNS depressant effect when combined with CNS depressants

clorazepic acid

may have an increased CNS depressant effect when combined with CNS depressants

isoflurane

may have an increased CNS depressant effect when combined with CNS depressants

promazine

may have an increased CNS depressant effect when combined with CNS depressants

onabotulinumtoxinA

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

apomorphine

may have an increased CNS depressive effect when combined with CNS depressants

flurazepam

may have an increased CNS depressive effect when combined with CNS depressants

perphenazine

may have an increased CNS depressive effect when combined with CNS depressants

botulinum toxin

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

abobotulinumtoxinA

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

rimabotulinumtoxinB

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

daxibotulinumtoxinA

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

prabotulinumtoxinA

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

botulinum toxin

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

abobotulinumtoxinA

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

rimabotulinumtoxinB

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

daxibotulinumtoxinA

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

prabotulinumtoxinA

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

pancuronium

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

botulinum toxin

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

abobotulinumtoxinA

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

rimabotulinumtoxinB

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

daxibotulinumtoxinA

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

potassium iodide

may decrease the levels of serum concentration

propylthiouracil

may decrease the levels of serum concentration

liotrix

may decrease the levels of serum concentration

potassium perchlorate

may decrease the levels of serum concentration

ibandronate

may decrease the effects of the drug by GI absorption inhibition

 

Dosage Forms & Strengths 

Tablet 

100mg  

Liquid 

290mg/5ml 

Constipation 

Indicated as laxative:


195–300 mL PO, either as a single dose or split doses, with a full glass of water each day
Alternatively,2 to 4 tablets orally in the night-time



Dietary Supplement 

Indicated for nutritional supplement:


>30 years:
The current recommendations for daily magnesium intake are:
Adult men (31 years and older): 420 mg/day
Adult women (31 years and older): 320 mg/day
Pregnant women: 350-400 mg/day
Breastfeeding women: 310-360 mg/day
<30 years: The NIH recommends the following daily magnesium intake for individuals aged 19-30: Adult men (19-30 years): 400 mg/day Adult women (19-30 years): 310 mg/day Pregnant women: 350-400 mg/day Breastfeeding women: 310-360 mg/day



Acid Indigestion 

One tablet two times a day



 

Dosage Forms & Strengths 

Tablet 

100mg  

Liquid 

290mg/5ml 

Constipation 

<2 years: Safety and Efficacy not established
2 to 6 years: 60 to 90ml orally in a single or divided dose. Do not exceed 90ml for 24 hours
6 to 12 years: 90 to 210ml orally in a single dose or divided doses with a full glass of water
>12 years: 195 to 300ml orally in a single dose or in divided doses with a full glass of water
Administer 2 to 4 tablets orally before bedtime



 

Refer adult dosing 

Frequency not defined 

Diarrhea 

Hypermagnesemia 

Nausea/vomiting 

Abdominal cramping 

Electrolyte imbalance 

Gas formation 

Contraindications/caution: 

Contraindications: 

The contraindications of magnesium citrate include: 

  • Allergy or hypersensitivity: Individuals allergic or hypersensitive to magnesium citrate or its ingredients should not take this medication. 
  • Kidney disease: magnesium citrate is primarily excreted by the kidneys, and individuals with impaired kidney function may not be able to clear the medication from their system correctly. This can lead to an accumulation of magnesium in the body, which can cause serious side effects. 
  • Bowel obstruction: magnesium citrate should not be used by individuals with a known or suspected bowel obstruction, as it can worsen it. 
  • Abdominal pain or vomiting: Individuals experiencing severe abdominal pain or vomiting should not use magnesium citrate, as it can exacerbate these symptoms. 
  • Dehydration: magnesium citrate can increase the risk of dehydration, especially in individuals who are elderly, have underlying medical conditions, or are taking certain medications. 
  • Pregnancy and breast-feeding: The safety of magnesium citrate use during pregnancy and breastfeeding has not been established, and it should only be used under the guidance of a healthcare provider. 

Caution: 

  • Electrolyte imbalances: magnesium citrate can cause changes in electrolyte levels, particularly if taken in high doses or for an extended period. This can lead to symptoms such as muscle weakness, cramping, and irregular heartbeat. 
  • Medication interactions: magnesium citrate can interact with certain medications, including antibiotics, blood pressure medications, and muscle relaxants. If you take any medications, you must talk to your healthcare provider before using magnesium citrate. 
  • Chronic constipation: While magnesium citrate is effective for relieving occasional constipation, it should not be used as a long-term solution for chronic constipation. Addressing the underlying causes of constipation and working with a healthcare provider to develop an appropriate treatment plan is essential. 
  • Intestinal disorders: Individuals with inflammatory bowel disease or other intestinal disorders should use magnesium citrate cautiously, as it can aggravate these conditions. 
  • Impaired swallowing: magnesium citrate is typically taken as a liquid, and individuals with impaired swallowing may have difficulty taking it. In these cases, an alternative form of magnesium may be more appropriate. 

Pregnancy consideration: A 

Lactation: Excretion of the drug in human breast milk is known 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology: 

  • magnesium citrate is a medication used primarily as a laxative to relieve constipation. The pharmacology of magnesium citrate is based on its ability to attract water into the colon, which softens the stool and promotes bowel movements. 
  • magnesium citrate is a salt that is composed of magnesium and citric acid. When taken orally, it dissociates into magnesium and citrate ions in the stomach. The magnesium ions are then absorbed into the bloodstream and transported to the colon, where they exert their laxative effects. 
  • magnesium ions attract water into the colon by increasing the osmotic pressure, which softens the stool and its volume. This increased water content in the colon stimulates peristalsis, the rhythmic contraction of the intestinal muscles that move stool through the digestive tract. This helps to promote bowel movements and relieve constipation. 

Pharmacodynamics: 

  • The pharmacodynamics of magnesium citrate involves its mechanism of action and its effects on the body. As a laxative, magnesium citrate attracts water into the colon, softening the stool and promoting bowel movements. 
  • The main active ingredient in magnesium citrate is magnesium, an essential mineral that plays a crucial role in many physiological processes in the body. Magnesium is required for the proper functioning of muscles, nerves, and the cardiovascular system, and it also plays a role in bone health and the immune system. 
  • When magnesium citrate is taken orally, the magnesium ions dissociate and are absorbed into the bloodstream. Once in the colon, magnesium ions attract water into the colon by increasing the osmotic pressure, which softens the stool and promotes bowel movements. Depending on the dose and individual response, this effect can occur within 30 minutes to 6 hours after taking the medication. 

Pharmacokinetics: 

Absorption 

magnesium citrate is administered orally and is rapidly absorbed from the gastrointestinal tract. Food enhances absorption, which slows gastric emptying and increases the time that magnesium citrate is in contact with the intestinal wall. The absorption of magnesium citrate can be affected by medications, food, and other factors that affect gastrointestinal motility.  

Distribution 

Once absorbed, magnesium citrate is distributed throughout the body, with the highest concentrations in the bones, muscles, and soft tissues. magnesium citrate crosses the blood-brain barrier and the placenta and is also excreted into breast milk.  

Metabolism 

magnesium citrate is not metabolized in the body and is excreted unchanged.  

Elimination and Excretion 

magnesium citrate is primarily excreted by the kidneys, with about 50% of the dose excreted in the urine within 24 hours of administration. In individuals with impaired kidney function, the medication may not be adequately cleared from the body, leading to an accumulation of magnesium and potential adverse effects. 

Administration: 

magnesium citrate is usually taken orally as a liquid solution. Here are some general guidelines for the administration of magnesium citrate: 

  • Shake the bottle well before use. 
  • Measure the recommended dose of magnesium citrate using the measuring cup provided with the medication. Do not use a household teaspoon or tablespoon to measure the dose. 
  • magnesium citrate may be taken with or without food. However, taking it with food may reduce the risk of gastrointestinal side effects. 
  • Drink plenty of water or clear liquids while taking magnesium citrate to help prevent dehydration and promote bowel movements. 
  • Taking magnesium citrate at least 2 hours before or after taking other medications is recommended to prevent interactions. 
  • Do not take magnesium citrate longer than recommended, which may lead to electrolyte imbalances and other adverse effects. 
  • If you miss a dose of magnesium citrate, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. 

Patient information leaflet 

Generic Name: magnesium citrate 

Why do we use magnesium citrate? 

  • magnesium citrate is primarily used as a laxative to relieve constipation and promote bowel movements. It is also used for bowel preparation before surgical procedures or diagnostic tests such as colonoscopy. 
  • In addition to its laxative effects, magnesium citrate can neutralize stomach acid and reduce symptoms of heartburn, indigestion, and acid reflux. This is due to its ability to react with stomach acid to form magnesium chloride, which has an antacid effect. 
  • magnesium citrate may also be used to treat magnesium deficiency, which can occur in individuals with certain medical conditions or those on long-term medications that interfere with magnesium absorption. 
Content loading

magnesium citrate

Brand Name :

Citroma, Citroma Lemon,nCitrate of Magnesia

Synonyms :

magnesium citrate

Class :

Laxative

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No data available for drug.

Dosage Forms & Strengths 

Tablet 

100mg  

Liquid 

290mg/5ml 

Constipation 

Indicated as laxative:


195–300 mL PO, either as a single dose or split doses, with a full glass of water each day
Alternatively,2 to 4 tablets orally in the night-time



Dietary Supplement 

Indicated for nutritional supplement:


>30 years:
The current recommendations for daily magnesium intake are:
Adult men (31 years and older): 420 mg/day
Adult women (31 years and older): 320 mg/day
Pregnant women: 350-400 mg/day
Breastfeeding women: 310-360 mg/day
<30 years: The NIH recommends the following daily magnesium intake for individuals aged 19-30: Adult men (19-30 years): 400 mg/day Adult women (19-30 years): 310 mg/day Pregnant women: 350-400 mg/day Breastfeeding women: 310-360 mg/day



Acid Indigestion 

One tablet two times a day



Dosage Forms & Strengths 

Tablet 

100mg  

Liquid 

290mg/5ml 

Constipation 

<2 years: Safety and Efficacy not established
2 to 6 years: 60 to 90ml orally in a single or divided dose. Do not exceed 90ml for 24 hours
6 to 12 years: 90 to 210ml orally in a single dose or divided doses with a full glass of water
>12 years: 195 to 300ml orally in a single dose or in divided doses with a full glass of water
Administer 2 to 4 tablets orally before bedtime



Refer adult dosing 

DRUG INTERACTION

magnesium citrate

&

magnesium citrate + 

Severity : Contraindicated
acalabrutinib: they may enhance the serum concentration of magnesium salts

bismuth subcitrate, metronidazole and tetracycline

magnesium salts may decrease the absorption of tetracyclines

demeclocycline

magnesium salts may decrease the absorption of tetracyclines

omadacycline

magnesium salts may decrease the absorption of tetracyclines

demeclocycline hydrochloride

magnesium salts may decrease the absorption of tetracyclines

doxycycline

magnesium salts may decrease the absorption of tetracyclines

alpha-lipoic acid 

may enhance the serum concentration of magnesium salts

ferric sulfate

may have a decreased serum concentration when combined with phosphate supplements

lanthanum carbonate

may have a decreased serum concentration when combined with phosphate supplements

sevelamer

may have a decreased serum concentration when combined with phosphate supplements

tetraferric tricitrate decahydrate

may have a decreased serum concentration when combined with phosphate supplements

aluminum hydroxide

may have a decreased serum concentration when combined with phosphate supplements

bismuth subcitrate, metronidazole and tetracycline

may have a decreased absorption when combined with tetracyclines

demeclocycline

may have a decreased absorption when combined with tetracyclines

omadacycline

may have a decreased absorption when combined with tetracyclines

demeclocycline hydrochloride

may have a decreased absorption when combined with tetracyclines

doxycycline

may have a decreased absorption when combined with tetracyclines

l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine

may reduce the levels of serum concentration of multivitamins

hydroxychloroquine

may reduce the level of serum concentration of quinolones

sparfloxacin

may reduce the level of serum concentration of quinolones

minocycline

may diminish the absorption when combined with tetracyclines

betamethasone (systemic)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

budesonide (oral inhalation)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

budesonide intranasal

magnesium salts: they may diminish the bioavailability of corticosteroids A1

budesonide (Topical)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

beclomethasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids A1

beclomethasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J3

fluticasone (topical)

magnesium salts: they may diminish the bioavailability of corticosteroids J3

beclomethasone dipropionate

magnesium salts: they may diminish the bioavailability of corticosteroids J3

fluticasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J3

beclomethasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J4

fluticasone (topical)

magnesium salts: they may diminish the bioavailability of corticosteroids J4

beclomethasone dipropionate

magnesium salts: they may diminish the bioavailability of corticosteroids J4

fluticasone (nasal)

magnesium salts: they may diminish the bioavailability of corticosteroids J4

calcium polycarbophil

magnesium salts: they may diminish the absorption of phosphate binders

dolutegravir

magnesium Salts may decrease the serum concentration of Dolutegravir

hydroxychloroquine

magnesium Salts may decrease the serum concentration of quinolones

sparfloxacin

magnesium Salts may decrease the serum concentration of quinolones

gemifloxacin 

may diminish the serum concentration of quinolones

doxercalciferol 

may have an increased hypermagnesemic effect when combined with magnesium salts

alpha-lipoic acid 

may have a decreased absorption when combined with alpha-lipoic acid

calcitriol 

may increase the serum concentration when combined with magnesium salts

dolutegravir 

may have a decreased serum concentration when combined with dolutegravir

hydroxychloroquine

may have a decreased serum concentration when combined with quinolones

sparfloxacin

may have a decreased serum concentration when combined with quinolones

bismuth subcitrate, metronidazole and tetracycline

may diminish the absorption when combined with tetracyclines

demeclocycline

may diminish the absorption when combined with tetracyclines

omadacycline

may diminish the absorption when combined with tetracyclines

demeclocycline hydrochloride

may diminish the absorption when combined with tetracyclines

minocycline

may diminish the absorption when combined with tetracyclines

acalabrutinib 

acalabrutinib: they may diminish the serum concentration of magnesium salts

alfacalcidol 

alfacalcidol: they may enhance the serum concentration of magnesium salts

acalabrutinib: they may enhance the serum concentration of magnesium salts

atazanavir 

atazanavir: they may diminish the absorption of magnesium salts

cefuroxime 

cefuroxime: they may diminish the serum concentration of magnesium salts

chloroquine 

chloroquine: they may diminish the serum concentration of magnesium salts

dabigatran 

dabigatran: they may diminish the serum concentration of magnesium salts

delavirdine 

delavirdine: they may diminish the serum concentration of magnesium salts

eltrombopag 

eltrombopag: they may increase the hypermagnesemic effect of magnesium salts

fosinopril 

fosinopril: they may increase the CNS depressant effect of magnesium salts

infigratinib 

infigratinib: they may diminish serum concentrations of magnesium salts

raltegravir 

may diminish the serum concentration of magnesium salts

bismuth subcitrate, metronidazole and tetracycline

may diminish the absorption of magnesium salts

demeclocycline

may diminish the absorption of magnesium salts

omadacycline

may diminish the absorption of magnesium salts

demeclocycline hydrochloride

may diminish the absorption of magnesium salts

minocycline

may diminish the absorption of magnesium salts

hydroxychloroquine

may diminish the serum concentration of magnesium salts

sparfloxacin

may diminish the serum concentration of magnesium salts

aluminum hydroxide

may diminish the serum concentration of magnesium salts

calcium polycarbophil

may diminish the serum concentration of magnesium salts

ferric sulfate

may diminish the serum concentration of magnesium salts

lanthanum carbonate

may diminish the serum concentration of magnesium salts

sevelamer

may diminish the serum concentration of magnesium salts

l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine

may diminish the serum concentration of magnesium salts

etidronate

may diminish the serum concentration of polyvalent cation-containing products

zoledronic acid

may diminish the serum concentration of polyvalent cation-containing products

alendronic acid

may diminish the serum concentration of polyvalent cation-containing products

ibandronate

may diminish the serum concentration of polyvalent cation-containing products

pamidronic acid

may diminish the serum concentration of polyvalent cation-containing products

demeclocycline

it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)

doxycycline

it may inhibit the GI absorption of doxycycline (provide 2 hours difference between both drugs)

raltegravir 

may diminish the serum concentration when combined with raltegravir

gabapentin 

may have an increased CNS depressant effect when combined with gabapentin

levothyroxine 

may have a decreased serum concentration when combined with levothyroxine

multivitamins 

may have a decreased serum concentration when combined with fluoride/multivitamins (with ADE)

magnesium glucoheptonate 

may decrease the serum concentration of Polyvalent Cation Containing Products

levonorgestrel 

levonorgestrel: they may diminish the serum concentration of magnesium salts

botulinum toxin

magnesium salts may increase the effect of neuromuscular-blocking agents

abobotulinumtoxinA

magnesium salts may increase the effect of neuromuscular-blocking agents

rimabotulinumtoxinB

magnesium salts may increase the effect of neuromuscular-blocking agents

daxibotulinumtoxinA

magnesium salts may increase the effect of neuromuscular-blocking agents

prabotulinumtoxinA

magnesium salts may increase the effect of neuromuscular-blocking agents

pancuronium

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

botulinum toxin

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

abobotulinumtoxinA

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

rimabotulinumtoxinB

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

daxibotulinumtoxinA

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

pancuronium

may increase the neuromuscular-blocking effect of magnesium Salts

botulinum toxin

may increase the neuromuscular-blocking effect of magnesium Salts

abobotulinumtoxinA

may increase the neuromuscular-blocking effect of magnesium Salts

rimabotulinumtoxinB

may increase the neuromuscular-blocking effect of magnesium Salts

daxibotulinumtoxinA

may increase the neuromuscular-blocking effect of magnesium Salts

pancuronium

may increase the effect of neuromuscular-blocking agents

tetracycline

may reduce the rate of absorption of tetracyclines

doxycycline

may reduce the rate of absorption of tetracyclines

minocycline

may reduce the rate of absorption of tetracyclines

sodium polystyrene sulfonate 

It may enhance the levels when combined with sodium polystyrene sulfonate by diminishing renal clearance

vitamin d 

It may enhance the effects when combined with vitamin D

misoprostol 

it may enhance the risk of side effects when combined with misoprostol

diphenoxylate/atropine

may have an increased CNS depressant effect when combined with CNS depressants

phenobarbital

may have an increased CNS depressant effect when combined with CNS depressants

clorazepic acid

may have an increased CNS depressant effect when combined with CNS depressants

isoflurane

may have an increased CNS depressant effect when combined with CNS depressants

promazine

may have an increased CNS depressant effect when combined with CNS depressants

onabotulinumtoxinA

may have an increased the neuromuscular-blocking effect when combined with neuromuscular-blocking agents

apomorphine

may have an increased CNS depressive effect when combined with CNS depressants

flurazepam

may have an increased CNS depressive effect when combined with CNS depressants

perphenazine

may have an increased CNS depressive effect when combined with CNS depressants

botulinum toxin

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

abobotulinumtoxinA

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

rimabotulinumtoxinB

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

daxibotulinumtoxinA

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

prabotulinumtoxinA

It may increase the neuromuscular-blocking effect of Neuromuscular-Blocking Agents

botulinum toxin

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

abobotulinumtoxinA

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

rimabotulinumtoxinB

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

daxibotulinumtoxinA

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

prabotulinumtoxinA

may enhance the neuromuscular-blocking effect of neuromuscular-blocking agents

pancuronium

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

botulinum toxin

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

abobotulinumtoxinA

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

rimabotulinumtoxinB

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

daxibotulinumtoxinA

may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents

potassium iodide

may decrease the levels of serum concentration

propylthiouracil

may decrease the levels of serum concentration

liotrix

may decrease the levels of serum concentration

potassium perchlorate

may decrease the levels of serum concentration

ibandronate

may decrease the effects of the drug by GI absorption inhibition

Actions and Spectrum: 

  • magnesium citrate is a medication used to relieve constipation and promote bowel movements. Its mechanism of action involves attracting water into the colon, which softens the stool and increases its volume. This helps to stimulate bowel movements and alleviate constipation. 
  • magnesium citrate increases the osmotic pressure in the intestines, attracting water into the colon and softening the stool. This increased water content in the colon stimulates peristalsis (the contractions of the intestinal muscles that move stool through the digestive tract), helping to promote bowel movements. 
  • In addition to its use as a laxative, magnesium citrate is sometimes used to treat conditions such as heartburn, indigestion, and acid reflux. It can help to neutralize stomach acid and reduce the symptoms of these conditions. 
  • magnesium citrate has a broad spectrum of activity, effectively treating constipation in people of all ages and backgrounds. 

Frequency not defined 

Diarrhea 

Hypermagnesemia 

Nausea/vomiting 

Abdominal cramping 

Electrolyte imbalance 

Gas formation 

Contraindications/caution: 

Contraindications: 

The contraindications of magnesium citrate include: 

  • Allergy or hypersensitivity: Individuals allergic or hypersensitive to magnesium citrate or its ingredients should not take this medication. 
  • Kidney disease: magnesium citrate is primarily excreted by the kidneys, and individuals with impaired kidney function may not be able to clear the medication from their system correctly. This can lead to an accumulation of magnesium in the body, which can cause serious side effects. 
  • Bowel obstruction: magnesium citrate should not be used by individuals with a known or suspected bowel obstruction, as it can worsen it. 
  • Abdominal pain or vomiting: Individuals experiencing severe abdominal pain or vomiting should not use magnesium citrate, as it can exacerbate these symptoms. 
  • Dehydration: magnesium citrate can increase the risk of dehydration, especially in individuals who are elderly, have underlying medical conditions, or are taking certain medications. 
  • Pregnancy and breast-feeding: The safety of magnesium citrate use during pregnancy and breastfeeding has not been established, and it should only be used under the guidance of a healthcare provider. 

Caution: 

  • Electrolyte imbalances: magnesium citrate can cause changes in electrolyte levels, particularly if taken in high doses or for an extended period. This can lead to symptoms such as muscle weakness, cramping, and irregular heartbeat. 
  • Medication interactions: magnesium citrate can interact with certain medications, including antibiotics, blood pressure medications, and muscle relaxants. If you take any medications, you must talk to your healthcare provider before using magnesium citrate. 
  • Chronic constipation: While magnesium citrate is effective for relieving occasional constipation, it should not be used as a long-term solution for chronic constipation. Addressing the underlying causes of constipation and working with a healthcare provider to develop an appropriate treatment plan is essential. 
  • Intestinal disorders: Individuals with inflammatory bowel disease or other intestinal disorders should use magnesium citrate cautiously, as it can aggravate these conditions. 
  • Impaired swallowing: magnesium citrate is typically taken as a liquid, and individuals with impaired swallowing may have difficulty taking it. In these cases, an alternative form of magnesium may be more appropriate. 

Pregnancy consideration: A 

Lactation: Excretion of the drug in human breast milk is known 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology: 

  • magnesium citrate is a medication used primarily as a laxative to relieve constipation. The pharmacology of magnesium citrate is based on its ability to attract water into the colon, which softens the stool and promotes bowel movements. 
  • magnesium citrate is a salt that is composed of magnesium and citric acid. When taken orally, it dissociates into magnesium and citrate ions in the stomach. The magnesium ions are then absorbed into the bloodstream and transported to the colon, where they exert their laxative effects. 
  • magnesium ions attract water into the colon by increasing the osmotic pressure, which softens the stool and its volume. This increased water content in the colon stimulates peristalsis, the rhythmic contraction of the intestinal muscles that move stool through the digestive tract. This helps to promote bowel movements and relieve constipation. 

Pharmacodynamics: 

  • The pharmacodynamics of magnesium citrate involves its mechanism of action and its effects on the body. As a laxative, magnesium citrate attracts water into the colon, softening the stool and promoting bowel movements. 
  • The main active ingredient in magnesium citrate is magnesium, an essential mineral that plays a crucial role in many physiological processes in the body. Magnesium is required for the proper functioning of muscles, nerves, and the cardiovascular system, and it also plays a role in bone health and the immune system. 
  • When magnesium citrate is taken orally, the magnesium ions dissociate and are absorbed into the bloodstream. Once in the colon, magnesium ions attract water into the colon by increasing the osmotic pressure, which softens the stool and promotes bowel movements. Depending on the dose and individual response, this effect can occur within 30 minutes to 6 hours after taking the medication. 

Pharmacokinetics: 

Absorption 

magnesium citrate is administered orally and is rapidly absorbed from the gastrointestinal tract. Food enhances absorption, which slows gastric emptying and increases the time that magnesium citrate is in contact with the intestinal wall. The absorption of magnesium citrate can be affected by medications, food, and other factors that affect gastrointestinal motility.  

Distribution 

Once absorbed, magnesium citrate is distributed throughout the body, with the highest concentrations in the bones, muscles, and soft tissues. magnesium citrate crosses the blood-brain barrier and the placenta and is also excreted into breast milk.  

Metabolism 

magnesium citrate is not metabolized in the body and is excreted unchanged.  

Elimination and Excretion 

magnesium citrate is primarily excreted by the kidneys, with about 50% of the dose excreted in the urine within 24 hours of administration. In individuals with impaired kidney function, the medication may not be adequately cleared from the body, leading to an accumulation of magnesium and potential adverse effects. 

Administration: 

magnesium citrate is usually taken orally as a liquid solution. Here are some general guidelines for the administration of magnesium citrate: 

  • Shake the bottle well before use. 
  • Measure the recommended dose of magnesium citrate using the measuring cup provided with the medication. Do not use a household teaspoon or tablespoon to measure the dose. 
  • magnesium citrate may be taken with or without food. However, taking it with food may reduce the risk of gastrointestinal side effects. 
  • Drink plenty of water or clear liquids while taking magnesium citrate to help prevent dehydration and promote bowel movements. 
  • Taking magnesium citrate at least 2 hours before or after taking other medications is recommended to prevent interactions. 
  • Do not take magnesium citrate longer than recommended, which may lead to electrolyte imbalances and other adverse effects. 
  • If you miss a dose of magnesium citrate, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. 

Patient information leaflet 

Generic Name: magnesium citrate 

Why do we use magnesium citrate? 

  • magnesium citrate is primarily used as a laxative to relieve constipation and promote bowel movements. It is also used for bowel preparation before surgical procedures or diagnostic tests such as colonoscopy. 
  • In addition to its laxative effects, magnesium citrate can neutralize stomach acid and reduce symptoms of heartburn, indigestion, and acid reflux. This is due to its ability to react with stomach acid to form magnesium chloride, which has an antacid effect. 
  • magnesium citrate may also be used to treat magnesium deficiency, which can occur in individuals with certain medical conditions or those on long-term medications that interfere with magnesium absorption. 

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