The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Nuzyra
(United States) [Available]Synonyms :
omadacycline 
Class :
Tetracyclines
Brand Name :
Nuzyra
(United States) [Available]Synonyms :
omadacycline 
Class :
Tetracyclines
Dosage Forms & Strengths Â
Tablet Â
150mg   Â
Loading Dose: 200 mg via IV infusion for 1 hour on day 1 or 100 mg via IV infusion for 30mins two times on day 1 or 300 mg orally two times on day 1
Maintenance Dose: 100 mg via IV infusion for 30mins per day or 300 mg orally per day
the maximum duration of treatment is 7-14 days
Loading Dose: 200 mg via IV infusion for 1 hour on day 1 or 100 mg via IV infusion for 30mins two times on day 1 or 300 mg orally two times on day 1
Maintenance Dose: 100 mg via IV infusion for 30mins per day or 300 mg orally per day
the maximum duration of treatment is 7-14 days
when both drugs are combined, there may be increased toxicity of omadacycline
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
lansoprazole, amoxicillin, and clarithromycin
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
amoxicillin and clavulanate potassium
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
may diminish the absorption of iron preparations
may diminish the serum concentration when combined with tetracyclines
may diminish the serum concentration when combined with tetracyclines
may diminish the absorption of magnesium salts
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
aluminum hydroxide/magnesium carbonateÂ
may decrease the serum concentration of antacids
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
when both drugs are combined, there may be a decreased effects of amoxicillin
when both drugs are combined, there may be a decreased effects of ampicillin
when both drugs are combined, there may be an increased effect of atracurium
when both drugs are combined, there may be increased toxicity of omadacycline
when both drugs are combined, there may be a decreased effect of the vaccine Â
when both drugs are combined, there may be an increased effect of cisatracurium
when both drugs are combined, there may be an increased effect of dicloxacillin
when both drugs are combined, there may be increased toxicity of omadacycline
when both drugs are combined, there may be a decreased effect of nafcillin
when both drugs are combined, there may be a decreased effect of oxacillin
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with omadacycline it decreases the effects of action of drug by antagonism effect
amoxicillin and clavulanate potassium
when amoxicillin combines with omadacycline it decreases the effects of action of drug by antagonism effect
omeprazole amoxicillin and clarithromycin
when both drugs are combined, there may be a decreased effect of the drug's action by antagonism effect
when both drugs are combined, there may be a decreased effect of the drug's action by antagonism effect
may diminish the absorption of magnesium salts
aluminum hydroxide/magnesium hydroxideÂ
may diminish the absorption of Antacids
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
when both drugs are combined, there may be a decreased effect of omadacycline by inhibition of gi absorption
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
may reduce the therapeutic effect of penicillins
amoxicillin and clavulanate potassium
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may enhance the neuromuscular-blocking effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
It may diminish the levels when combined with sodium acid phosphate by inhibiting of gastrointestinal absorption
They may diminish the absorption when combined with bile acid sequestrants
The inhibition of gastrointestinal absorption caused by potassium aminobenzoate will result in a reduction in the level of omadacycline
It may diminish the effect when combined with manganese by inhibiting the gastrointestinal absorption
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
sodium picosulfate, citric acid, and magnesium oxide
may diminish the effect of each other when combined
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may increase the nephrotoxic effect of cephalosporins
neomycin/polymyxin B/bacitracin topical
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may increase the nephrotoxic effect of cephalosporins
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
may increase the hypoglycemic effect of sulfonylureas
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the rate of absorption
may decrease the rate of absorption
may decrease the rate of absorption
may decrease the rate of absorption
may diminish the absorption of magnesium salts
may diminish the absorption when combined with tetracyclines
It may enhance the risk of adverse effects when combined with Tetracyclines
by altering the gastrointestinal absorption, the activity of omadacycline may be reduced with cyanocobalamin
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
Omadacycline has a high degree of selectivity in binding to the bacterial 30s ribosomal subunit’s major tetracycline binding site.Â
To impair numerous aspects of cellular function and cause either cell death or stasis, it acts there to impede protein synthesis.Â
Adverse drug reactions: Â
Frequency defined Â
>10%  Â
Nausea  Â
Vomiting  Â
1-10%  Â
Hypertension  Â
Headache Â
Constipation Â
Increased GGT  Â
Increased ALT Â
Insomnia  Â
Increased AST Â
 Â
None
Contraindication:Â
HypersensitivityÂ
Caution:Â
HepatotoxicityÂ
Tooth Discoloration and Enamel HypoplasiaÂ
Bone Growth InhibitionÂ
PhotosensitivityÂ
Pregnancy warnings:   Â
Breastfeeding warnings:Â
Pregnancy Categories:     Â
The organism in question determines whether omadacycline is bacteriostatic or bacteriocidal. It interferes with bacterial protein synthesis but has no effect on peptidoglycan, DNA, or RNA production.Â
The fact that omadacycline is not susceptible to tetracycline resistance mediated by tetracycline efflux pumps makes it an improvement over current tetracycline medicine.Â
Patients should not eat or drink anything other than water for four hours prior to or two hours following the administration of omadacycline tablets.Â
Four hours after taking tablet, avoid consuming dairy products, antacids, or multivitamins.Â
For intravenous administration infuse through dedicated IV line or Y-site.Â
If multiple medications are infused sequentially into the same IV-line, flush with 0.9% NaCl or D5W both before and after omadacycline.Â
Patient information leafletÂ
Generic Name: omadacyclineÂ
Why do we use omadacycline? Â
Omadacycline is indicated for the treatment of bacterial pneumonia and acute bacterial skin.Â
It is also used in treatment of skin structure infections caused by omadacycline-susceptible organisms in adults.Â
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