Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Genotropin, Nutropin, Saizen, Humatrope, Norditropin
Synonyms :
somatotropin
Class :
Somatotropin Agonists
Brand Name :
Genotropin, Nutropin, Saizen, Humatrope, Norditropin
Synonyms :
somatotropin
Class :
Somatotropin Agonists
Dosage forms and strengths
Injection, powder, for solution
1.6 mg
1.4 mg
1.2 mg
1 mg
0.8 mg
0.6 mg
0.4 mg
0.2 mg
(Non-weight based)
Start with Norditropin 0.2 mg daily; the recommended range is 0.15 mg- 0.3 mg daily & escalate the daily dose at intervals of 1 to 2 months, with an increase of around 0.1 mg -0.2 mg daily
Based on requirements of every individual, considering their clinical response and levels of serum IGF-1
(Weight-based)
Start with Norditropin 0.004 mg/kg in a day to address individual patient needs, escalate the dosage incrementally up to a maximum of 0.016 mg/kg in a day
Dosage forms and strengths
Injection, powder, for solution
1.6 mg
1.4 mg
1.2 mg
1 mg
0.8 mg
0.6 mg
0.4 mg
0.2 mg
Take 0.17 mg/kg-0.24 mg/kg given in a week i.e 0.024 mg/kg -0.034 mg/kg daily
Refer adult dosing
may decrease the therapeutic effect when combined with growth hormone analogs
may decrease the therapeutic effect when combined with growth hormone analogs
bazedoxifene/conjugated estrogens
may decrease the therapeutic effect when combined with growth hormone analogs
may decrease the therapeutic effect when combined with growth hormone analogs
may decrease the therapeutic effect when combined with growth hormone analogs
estrogens esterified/methyltestosterone
may decrease the therapeutic effect of estrogen derivatives
cyproterone and ethinyl estradiol
may decrease the therapeutic effect of Estrogen Derivatives
etonogestrel/ethinyl estradiol
may diminish the therapeutic effect of estrogen derivatives
may decrease the therapeutic effect when combined with growth hormone analogs
may decrease the therapeutic effect when combined with growth hormone analogs
may decrease the diagnostic effect of macimorelin
Corticosteroids may diminish the therapeutic effect of Growth Hormone Analogs
Corticosteroids may diminish the therapeutic effect of Growth Hormone Analogs
Corticosteroids may diminish the therapeutic effect of Growth Hormone Analogs
Corticosteroids may diminish the therapeutic effect of Growth Hormone Analogs
Corticosteroids may diminish the therapeutic effect of Growth Hormone Analogs
it may diminish the excretion rate when combined with Growth hormone agonist, resulting in an enhanced serum level
it may diminish the excretion rate when combined with Growth hormone agonist, resulting in an enhanced serum level
it may diminish the excretion rate when combined with Growth hormone agonist, resulting in an enhanced serum level
it may diminish the excretion rate when combined with Growth hormone agonist, resulting in an enhanced serum level
it may diminish the excretion rate when combined with Growth hormone agonist, resulting in an enhanced serum level
may diminish the therapeutic effect
may decrease the therapeutic effect of corticosteroids
may diminish the therapeutic effect
may diminish the therapeutic effect
bazedoxifene/conjugated estrogens
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the therapeutic effect
When aminophylline is used together with somatotropin, this leads to a rise in aminophylline’s metabolism
When anagrelide is used together with somatotropin, this leads to a rise in aminophylline’s metabolism
When antipyrine is used together with somatotropin, this leads to a rise in aminophylline’s metabolism
When apremilast is used together with somatotropin, this leads to a rise in apremilast’s metabolism
When asenapine is used together with somatotropin, this leads to a rise in asenapine’s metabolism
axitinib When axitinib is used together with somatotropin, this leads to a rise in axitinib ‘s metabolism
When azathioprine is used together with somatotropin, this leads to a rise in azathioprine’s metabolism
When azelastine is used together with somatotropin, this leads to a rise in azelastine’s metabolism
When bendamustine is used together with somatotropin, this leads to a rise in bendamustine’s metabolism
When benzocaine is used together with somatotropin, this leads to a rise in benzocaine’s metabolism
When betaxolol is used together with somatotropin, this leads to a rise in betaxolol’s metabolism
When binimetinib is used together with somatotropin, this leads to a rise in binimetinib’s metabolism
When bortezomib is used together with somatotropin, this leads to a rise in bortezomib’s metabolism
When bromazepam is used together with somatotropin, this leads to a rise in bromazepam’s metabolism
When bromotheophylline is used together with somatotropin, this leads to a rise in bromotheophylline’s metabolism
When caffeine is used together with somatotropin, this leads to a rise in caffeine’s metabolism
When carmustine is used together with somatotropin, this leads to a rise in carmustine’s metabolism
When carvedilol is used together with somatotropin, this leads to a rise in carvedilol metabolism
When chlorpromazine is used together with somatotropin, this leads to a rise in chlorpromazine’s metabolism
When chlorzoxazone is used together with somatotropin, this leads to a rise in chlorzoxazone’s metabolism
When cinacalcet is used together with somatotropin, this leads to a rise in cinacalcet metabolism
When cinnarizine is used together with somatotropin, this leads to a rise in cinnarizine’s metabolism
When clonidine is used together with somatotropin, this leads to a rise in clonidine’s metabolism
When clopidogrel is used together with somatotropin, this leads to a rise in clopidogrel’s metabolism
When cyclobenzaprine is used together with somatotropin, this leads to a rise in cyclobenzaprine’s metabolism
When dacarbazine is used together with somatotropin, this leads to a rise in dacarbazine’s metabolism
When dasatinib is used together with somatotropin, this leads to a rise in dasatinib metabolism
When dexfenfluramine is used together with somatotropin, this leads to a rise in dexfenfluramine metabolism
When diclofenac is used together with somatotropin, this leads to a rise in diclofenac metabolism
When dihydralazine is used together with somatotropin, this leads to a rise in dihydralazine metabolism
When domperidone is used together with somatotropin, this leads to a rise in domperidone metabolism
When doxepin is used together with somatotropin, this leads to a rise in doxepin metabolism
When efavirenz is used together with somatotropin, this leads to a rise in efavirenz metabolism
When eltrombopag is used together with somatotropin, this leads to a rise in eltrombopag metabolism
When enasidenib is used together with somatotropin, this leads to a rise in enasidenib metabolism
When entecavir is used together with somatotropin, this leads to a rise in entecavir metabolism
When erlotinib is used together with somatotropin, this leads to a rise in erlotinib metabolism
benzoate When estradiol benzoate is used together with somatotropin, this leads to a rise in estradiol benzoate metabolism
When etoposide is used together with somatotropin, this leads to a rise in etoposide metabolism
When etoricoxib is used together with somatotropin, this leads to a rise in etoricoxib metabolism
When fenfluramine is used together with somatotropin, this leads to a rise in fenfluramine metabolism
When fexinidazole is used together with somatotropin, this leads to a rise in fexinidazole metabolism
When fezolinetant is used together with somatotropin, this leads to a rise in fezolinetant metabolism
When flecainide is used together with somatotropin, this leads to a rise in flecainide metabolism
When flunarizine is used together with somatotropin, this leads to a rise in flunarizine metabolism
When fluorouracil is used together with somatotropin, this leads to a rise in fluorouracil metabolism
When fluoxetine is used together with somatotropin, this leads to a rise in fluoxetine metabolism
When flutamide is used together with somatotropin, this leads to a rise in flutamide metabolism
When fluvoxamine is used together with somatotropin, this leads to a rise in fluvoxamine metabolism
When frovatriptan is used together with somatotropin, this leads to a rise in frovatriptan metabolism
When guanabenz is used together with somatotropin, this leads to a rise in guanabenz metabolism
When haloperidol is used together with somatotropin, this leads to a rise in haloperidol metabolism
When imatinib is used together with somatotropin, this leads to a rise in imatinib metabolism
When imipramine is used together with somatotropin, this leads to a rise in imipramine metabolism
When levobupivacaine is used together with somatotropin, this leads to a rise in levobupivacaine metabolism
When lidocaine is used together with somatotropin, this leads to a rise in lidocaine metabolism
When lomefloxacin is used together with somatotropin, this leads to a rise in lomefloxacin metabolism
When lorcaserin is used together with somatotropin, this leads to a rise in lorcaserin metabolism
When maprotiline is used together with somatotropin, this leads to a rise in maprotiline metabolism
When mefenamic acid is used together with somatotropin, this leads to a rise in mefenamic acid metabolism
When melatonin is used together with somatotropin, this leads to a rise in melatonin metabolism
When mephenytoin is used together with somatotropin, this leads to a rise in mephenytoin metabolism
When acenocoumarol is used together with somatotropin, this leads to a rise in acenocoumarol’s metabolism
When acetaminophen is used together with somatotropin, this leads to a rise in acetaminophen’s metabolism
When acyclovir is used together with somatotropin, this leads to a rise in acyclovir’s metabolism
When agomelatine is used together with somatotropin, this leads to a rise in agomelatine’s metabolism
When albendazole is used together with somatotropin, this leads to a rise in albendazole metabolism
When alosetron is used together with somatotropin, this leads to a rise in alosetron metabolism
When aminophenazone is used together with somatotropin, this leads to a rise in aminophenazone’s metabolism
Actions and Spectrum:
Action:
Stimulation of Growth: somatotropin primarily promotes growth during childhood and adolescence. It stimulates the growth of long limb bones, contributing to increased height. This growth-promoting effect is due to stimulating cell division and growth in the epiphyseal plates of bones.
Connective Tissue and Organ Growth: somatotropin not only influences skeletal growth but also affects the growth and maintenance of organs and connective tissues throughout life.
Frequency not defined
Swelling
Redness
Itching
Fever
Pain
Sore throat
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: Individuals with a known hypersensitivity or allergy to somatotropin or its components should not use this medication.
Active Cancer: somatotropin should not be administered to patients with active malignancies or a history of cancer, as it may stimulate the growth of existing tumors.
Diabetic Retinopathy: Patients with active diabetic retinopathy, a condition affecting the blood vessels in the eyes, should not use somatotropin, as it may exacerbate the condition.
Prader-Willi Syndrome: Patients with Prader-Willi syndrome should be carefully evaluated for risk factors, including respiratory impairment, prior to initiating somatotropin therapy.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
somatotropin, also known as growth hormone (GH), is a peptide hormone produced and released by the anterior pituitary gland in the brain.
Pharmacodynamics:
Stimulation of Growth: somatotropin primarily stimulates the growth of bones and tissues in the body, especially during childhood and adolescence. It promotes the growth and proliferation of chondrocytes (cartilage cells) in the epiphyseal growth plates of long bones.
Stimulation of IGF-1 Production: One of the key mechanisms of somatotropin is the induction of insulin-like growth factor-1 (IGF-1) production in the liver.
Pharmacokinetics:
N/A
Administration:
Some forms of somatotropin come in a powder form and must be reconstituted with a diluent before administration. Follow the specific instructions provided with the medication. somatotropin is typically administered as a subcutaneous injection, which is injected just under the skin, often in the abdominal area.
Patient information leaflet
Generic Name: somatotropin
Why do we use somatotropin?
somatotropin is essential for the growth of children and adolescents. It promotes an increase in height and general body size by stimulating the growth of bones and tissues.
In addition from its role in stimulating linear growth, somatotropin also plays a vital role in facilitating the proliferation and rejuvenation of cells across the entire organism. This encompasses maintaining and restoring skin, vital organs, and muscular tissues.
somatotropin plays a significant role in regulating the metabolism of carbohydrates, fats, and proteins. It helps increase the breakdown of fats while conserving glucose and amino acids, which can lead to increased energy and lean muscle mass.
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