Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Captoril, Capoten
Synonyms :
captopril
Class :
ACE Inhibitors
Brand Name :
Captoril, Capoten
Synonyms :
captopril
Class :
ACE Inhibitors
Dosage Forms & Strengths Â
Tablet Â
12.5mg Â
25mg Â
50mg Â
100mg Â
Dosage Forms & Strengths Â
Tablet Â
12.5mg Â
25mg Â
50mg Â
100mg Â
Refer to adult dosingÂ
may increase the adverse effect of angiotensin II receptor blockers
may increase the adverse effect of angiotensin II receptor blockers
may increase the adverse effect of angiotensin ii receptor blockers
captopril: it may increase the risk of CNS depression
captopril: it may increase the risk of CNS depression
captopril: it may increase the risk of CNS depression
captopril: it may increase the risk of CNS depression
captopril: it may increase the risk of CNS depression
may increase the toxic effect of angiotensin receptor II blockers
lisinopril/hydrochlorothiazideÂ
may increase the toxic effect of angiotensin receptor II blockers
may enhance the hypotensive effect when combined with sparsentan
may diminish the serum concentration when combined with angiotensin-converting enzyme inhibitors
may enhance the serum concentration when combined with lithium
may have an increased hyperkalemic effect when combined with ACE inhibitors
may have an increased risk of rhabdomyolysis & myoglobinuria when combined with captopril
may have an increasingly adverse effect when combined with angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with angiotensin-converting enzyme inhibitors
may diminish the effects of indomethacin by pharmacodynamic antagonism
may diminish the effects of indomethacin by pharmacodynamic antagonism
may diminish the effects of indomethacin by pharmacodynamic antagonism
may diminish the effects of indomethacin by pharmacodynamic antagonism
may diminish the effects of indomethacin by pharmacodynamic antagonism
May enhances the effects of the other by pharmacodynamic synergism
may diminish the effects of ketoprofen by pharmacodynamic antagonism
may diminish the effects of indomethacin by pharmacodynamic antagonism
may have an increasingly adverse effect when combined with sacubitril
when both the drugs are combined, there might be an increase in the anticoagulant effect
A decrease in renal function may be seen when aspirin rectal and captopril are coadministered due to pharmacodynamic antagonism
antacids reduce the concentration of captopril in serum
antacids reduce the concentration of captopril in serum
antacids reduce the concentration of captopril in serum
antacids reduce the concentration of captopril in serum
antacids reduce the concentration of captopril in serum
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
May increase the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
ACE Inhibitors may enhance the therapeutic effect of angiotensin II receptor antagonists
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
It may enhance the toxicity when combined with mipomersen
captopril: they may diminish the serum concentration of antacids
captopril: they may diminish the serum concentration of antacids
captopril: they may diminish the serum concentration of antacids
captopril: they may diminish the serum concentration of antacids
captopril: they may diminish the serum concentration of antacids
antacids can lower the levels of captopril in the bloodstream
captopril: they may diminish the serum concentration of antacids
When captopril is used together with ouabain, this leads to reduction in captopril excretion
may have an increasingly adverse effect when combined with NSAIDs
captopril: it may increase the risk of gastrointestinal bleeding with risedronic acid
may increase the hypotensive effect of angiotensin-converting enzyme inhibitors
may increase the hypotensive effect of angiotensin-converting enzyme inhibitors
may increase the hypotensive effect of angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with NSAIDs
captopril's absorption may be reduced by almasilate, resulting in lower serum concentrations and potentially decreased efficacy
may enhance the risk of neutropenia
angiotensin-Converting Enzyme Inhibitors may enhance the hyperkalemic effect of finerenone
ACE Inhibitors may enhance the potential for allergic or hypersensitivity reactions to allopurinol
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
angiotensin-converting Enzyme (ACE) inhibitors may increase the risk of adverse effects of alteplase
insulin degludec/insulin aspartÂ
may diminish the effects of each other by pharmacodynamic antagonism
icatibant may reduce the antihypertensive effect of ACE inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may increase the anti-coagulant action of anti-coagulants
may increase the nephrotoxic effect of salicylates
may diminish the antihypertensive activity when combined
may have an increased allergic or hypersensitivity reactions when combined with allopurinol
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased orthostatic hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increasingly adverse effect when combined with angiotensin-converting enzyme inhibitors
may enhance the nephrotoxic effect of salicylates
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
drospirenone/ethinyl estradiol/levomefolateÂ
may increase the hyperkalemic effect of Drospirenone-Containing Products
may increase the effects of bosentan by pharmacodynamic synergism
choline magnesium trisalicylate
may have an increased nephrotoxic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with ACE inhibitors
may have an increased hypotensive effect when combined with ACE inhibitors
may have an increased hypotensive effect when combined with ACE inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
an increase in the severity of hypertension, kidney failure, or hyperkalemia may be seen when mofebutazone is administered with captopril
the risk of renal failure hyperkalemia and hypotension may be raised
clofarabine and captopril increase the effect of each other by pharmacodynamic synergism
when used in combination, nabilone and captopril both increase the effect of each other
Actions and SpectrumÂ
The primary action of captopril is to lower blood pressure by relaxing the blood vessels and reducing the workload of the heart. It does this by inhibiting the activity of ACE, an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows the blood vessels and increases blood pressure.
By blocking the production of angiotensin II, captopril can help to lower blood pressure and reduce the risk of cardiovascular events such as heart attack and stroke. captopril is also sometimes used to treat kidney problems caused by diabetes and to improve survival after a heart attack. It may be used in combination with other medications to achieve these effects.Â
In terms of its spectrum of activity, captopril is effective at lowering blood pressure in a wide range of patients, including those with hypertension, congestive heart failure, and kidney problems. It is generally well-tolerated, although some people may experience side effects such as dizziness, fatigue, and a dry cough.Â
Frequency Defined Â
>10% Â
Hyperkalemia (1-11%) Â
1-10% Â
Skin rash (4-7%) Â
Hypotension (1-2.5%) Â
Dysgeusia (2-4%) Â
Pruritus (2%) Â
Chest pain (1%) Â
Hypersensitivity rxns (4-7%) Â
Cough (0.5-2%) Â
Palpitations (1%) Â
Tachycardia (1%) Â
Proteinuria (1%) Â
Frequency Not Defined Â
Orthostatic hypotension Â
Cardiac arrest Â
Ataxia Â
Depression Â
Confusion Â
Somnolence Â
Photosensitivity Â
Angioedema Â
Black Box WarningÂ
The black box warning for captopril, a medication used to treat high blood pressure and heart failure, states that the drug can cause serious or life-threatening allergic reactions, including angioedema (swelling of the face, lips, tongue, or throat).
The warning also advises that captopril should not be used in patients with a history of angioedema or hypersensitivity to the drug. In addition, the black box warning for captopril notes that the drug can cause fetal harm when used during pregnancy and advises that it should be avoided in pregnant women or women who may become pregnant.Â
Contraindications:Â
Cautions:Â
Pregnancy warnings:    Â
US FDA pregnancy category: C; D in 2nd & 3rd trimestersÂ
Lactation:  Â
Excreted into human milk is known Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology: Â
captopril is a medication that belongs to a class of drugs known as angiotensin converting enzyme inhibitors (ACE inhibitors). It is used to treat hypertension (high blood pressure) and heart failure, as well as to prevent kidney damage in individuals with diabetes or hypertension.Â
Pharmacodynamics: Â
captopril is an angiotensin-converting enzyme (ACE) inhibitor, which means it works by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that increases blood pressure and constricts blood vessels. By inhibiting the conversion of angiotensin, I to angiotensin II, captopril causes blood vessels to relax and blood pressure to decrease.Â
captopril also increases the production of bradykinin, which is a chemical that causes blood vessels to dilate and reduces inflammation. captopril is primarily used to treat hypertension, but it can also be used to treat heart failure, kidney disease, and myocardial infarction. Â
The pharmacodynamics of captopril may be affected by certain factors such as age, weight, kidney function, and other medications being taken.Â
Pharmacokinetics: Â
Absorption  Â
It is absorbed rapidly after oral administration  Â
Distribution  Â
Reaches peak plasma concentrations within 1-2 hours. The bioavailability of captopril is low, around 10-20%, due to a high degree of first-pass metabolism in the liver. Â
Metabolism  Â
captopril is metabolized in the liver by the enzyme dipeptidyl peptidase IV (DPP-IV) to its active form, enalaprilat. Enalaprilat is highly protein bound, primarily to albumin. Â
Elimination and excretion Â
captopril is eliminated from the body primarily through the kidneys via glomerular filtration and tubular secretion. The half-life of captopril is 1-2 hours, while the half-life of enalaprilat is 4-6 hours. Â
Administration: Â
Oral administration: Â
captopril is an oral medication that is typically taken 1-3 times a day. It should be taken with food to help prevent stomach irritation. The dosage will depend on the patient’s blood pressure, kidney function, and other factors. It is important to follow the prescribed dosage and schedule as directed by a healthcare provider.  Â
Missed dose: Â
If a dose is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular schedule should be resumed. It is important not to take extra doses of captopril or to change the dosage without consulting a healthcare provider.  Â
Storage: Â
captopril should be stored at room temperature and kept out of reach of children. Â
Patient information leafletÂ
Generic Name: captopril Â
Why do we use captopril?Â
captopril is used to treat high blood pressure (hypertension) and heart failure. It belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors, which work by blocking the production of a hormone called angiotensin II. Angiotensin II constricts blood vessels and increases blood pressure, so by blocking its production, captopril helps to relax blood vessels and lower blood pressure. captopril may also be used to prevent kidney damage in people with diabetes and to treat kidney disorders caused by a protein called lupus nephritis.Â
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